These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
127 related articles for article (PubMed ID: 14640701)
21. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. Yu WH; Kumar A; Peterhoff C; Shapiro Kulnane L; Uchiyama Y; Lamb BT; Cuervo AM; Nixon RA Int J Biochem Cell Biol; 2004 Dec; 36(12):2531-40. PubMed ID: 15325590 [TBL] [Abstract][Full Text] [Related]
22. Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels. Rakover I; Arbel M; Solomon B Neurodegener Dis; 2007; 4(5):392-402. PubMed ID: 17536186 [TBL] [Abstract][Full Text] [Related]
23. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo. Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133 [TBL] [Abstract][Full Text] [Related]
24. Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site. Flood F; Murphy S; Cowburn RF; Lannfelt L; Walker B; Johnston JA Biochem J; 2005 Jan; 385(Pt 2):545-50. PubMed ID: 15473868 [TBL] [Abstract][Full Text] [Related]
25. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. Irizarry MC; Deng A; Lleo A; Berezovska O; Von Arnim CA; Martin-Rehrmann M; Manelli A; LaDu MJ; Hyman BT; Rebeck GW J Neurochem; 2004 Sep; 90(5):1132-43. PubMed ID: 15312168 [TBL] [Abstract][Full Text] [Related]
26. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop? Knappenberger KS; Tian G; Ye X; Sobotka-Briner C; Ghanekar SV; Greenberg BD; Scott CW Biochemistry; 2004 May; 43(20):6208-18. PubMed ID: 15147205 [TBL] [Abstract][Full Text] [Related]
27. Identification of novel APP/Abeta isoforms in human cerebrospinal fluid. Portelius E; Brinkmalm G; Tran AJ; Zetterberg H; Westman-Brinkmalm A; Blennow K Neurodegener Dis; 2009; 6(3):87-94. PubMed ID: 19229112 [TBL] [Abstract][Full Text] [Related]
28. Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model. Lichtenthaler SF; Haass C J Clin Invest; 2004 May; 113(10):1384-7. PubMed ID: 15146234 [TBL] [Abstract][Full Text] [Related]
29. Widespread gamma-secretase activity in the cell, but do we need it at the mitochondria? Teng FY; Tang BL Biochem Biophys Res Commun; 2005 Mar; 328(1):1-5. PubMed ID: 15670741 [TBL] [Abstract][Full Text] [Related]
30. Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]. Best JD; Jay MT; Otu F; Ma J; Nadin A; Ellis S; Lewis HD; Pattison C; Reilly M; Harrison T; Shearman MS; Williamson TL; Atack JR J Pharmacol Exp Ther; 2005 May; 313(2):902-8. PubMed ID: 15743924 [TBL] [Abstract][Full Text] [Related]
31. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition. Abramowski D; Wiederhold KH; Furrer U; Jaton AL; Neuenschwander A; Runser MJ; Danner S; Reichwald J; Ammaturo D; Staab D; Stoeckli M; Rueeger H; Neumann U; Staufenbiel M J Pharmacol Exp Ther; 2008 Nov; 327(2):411-24. PubMed ID: 18687920 [TBL] [Abstract][Full Text] [Related]
32. A synthetic substrate assay for the gamma-secretase of the beta-A4 amyloid of Alzheimer's disease. Evin G; Beyreuther K; Masters CL J Pept Sci; 1995; 1(2):132-9. PubMed ID: 9222990 [TBL] [Abstract][Full Text] [Related]
33. The use of seldi proteinchip arrays to monitor production of Alzheimer's betaamyloid in transfected cells. Austen BM; Frears ER; Davies H J Pept Sci; 2000 Sep; 6(9):459-69. PubMed ID: 11016883 [TBL] [Abstract][Full Text] [Related]
34. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells. Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548 [TBL] [Abstract][Full Text] [Related]
35. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment. Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373 [TBL] [Abstract][Full Text] [Related]
36. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease. Pollack SJ; Lewis H Curr Opin Investig Drugs; 2005 Jan; 6(1):35-47. PubMed ID: 15675602 [TBL] [Abstract][Full Text] [Related]
37. Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting. Kametani F FEBS Lett; 2004 Jul; 570(1-3):73-6. PubMed ID: 15251442 [TBL] [Abstract][Full Text] [Related]
38. The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain. Stockley JH; O'Neill C Biochem Soc Trans; 2007 Jun; 35(Pt 3):574-6. PubMed ID: 17511655 [TBL] [Abstract][Full Text] [Related]
39. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Majercak J; Ray WJ; Espeseth A; Simon A; Shi XP; Wolffe C; Getty K; Marine S; Stec E; Ferrer M; Strulovici B; Bartz S; Gates A; Xu M; Huang Q; Ma L; Shughrue P; Burchard J; Colussi D; Pietrak B; Kahana J; Beher D; Rosahl T; Shearman M; Hazuda D; Sachs AB; Koblan KS; Seabrook GR; Stone DJ Proc Natl Acad Sci U S A; 2006 Nov; 103(47):17967-72. PubMed ID: 17098871 [TBL] [Abstract][Full Text] [Related]
40. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage. Kume H; Maruyama K; Kametani F Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982 [TBL] [Abstract][Full Text] [Related] [Previous] [Next] [New Search]