136 related articles for article (PubMed ID: 14643307)
1. KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides.
Shuto D; Kasai S; Kimura T; Liu P; Hidaka K; Hamada T; Shibakawa S; Hayashi Y; Hattori C; Szabo B; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2003 Dec; 13(24):4273-6. PubMed ID: 14643307
[TBL] [Abstract][Full Text] [Related]
2. Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic.
Mimoto T; Imai J; Tanaka S; Hattori N; Takahashi O; Kisanuki S; Nagano Y; Shintani M; Hayashi H; Sakikawa H
Chem Pharm Bull (Tokyo); 1991 Sep; 39(9):2465-7. PubMed ID: 1804562
[TBL] [Abstract][Full Text] [Related]
3. KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.
Kimura T; Shuto D; Kasai S; Liu P; Hidaka K; Hamada T; Hayashi Y; Hattori C; Asai M; Kitazume S; Saido TC; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2004 Mar; 14(6):1527-31. PubMed ID: 15006396
[TBL] [Abstract][Full Text] [Related]
4. Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.
Kimura T; Shuto D; Hamada Y; Igawa N; Kasai S; Liu P; Hidaka K; Hamada T; Hayashi Y; Kiso Y
Bioorg Med Chem Lett; 2005 Jan; 15(1):211-5. PubMed ID: 15582441
[TBL] [Abstract][Full Text] [Related]
5. Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors.
Tagad HD; Hamada Y; Nguyen JT; Hidaka K; Hamada T; Sohma Y; Kimura T; Kiso Y
Bioorg Med Chem; 2011 Sep; 19(17):5238-46. PubMed ID: 21803585
[TBL] [Abstract][Full Text] [Related]
6. Novel non-peptidic and small-sized BACE1 inhibitors.
Hamada Y; Ohta H; Miyamoto N; Yamaguchi R; Yamani A; Hidaka K; Kimura T; Saito K; Hayashi Y; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2008 Mar; 18(5):1643-7. PubMed ID: 18261904
[TBL] [Abstract][Full Text] [Related]
7. Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.
Tagad HD; Hamada Y; Nguyen JT; Hamada T; Abdel-Rahman H; Yamani A; Nagamine A; Ikari H; Igawa N; Hidaka K; Sohma Y; Kimura T; Kiso Y
Bioorg Med Chem; 2010 May; 18(9):3175-86. PubMed ID: 20381362
[TBL] [Abstract][Full Text] [Related]
8. Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.
Suzuki K; Hamada Y; Nguyen JT; Kiso Y
Bioorg Med Chem; 2013 Nov; 21(21):6665-73. PubMed ID: 23993670
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors.
Liu J; Chen W; Xu Y; Ren S; Zhang W; Li Y
Bioorg Med Chem; 2015 May; 23(9):1963-74. PubMed ID: 25842365
[TBL] [Abstract][Full Text] [Related]
10. Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic.
Kiso Y; Matsumoto H; Mizumoto S; Kimura T; Fujiwara Y; Akaji K
Biopolymers; 1999; 51(1):59-68. PubMed ID: 10380353
[TBL] [Abstract][Full Text] [Related]
11. Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design.
Hamada Y; Tagad HD; Nishimura Y; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2012 Jan; 22(2):1130-5. PubMed ID: 22178553
[TBL] [Abstract][Full Text] [Related]
12. BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.
Hamada Y; Abdel-Rahman H; Yamani A; Nguyen JT; Stochaj M; Hidaka K; Kimura T; Hayashi Y; Saito K; Ishiura S; Kiso Y
Bioorg Med Chem Lett; 2008 Mar; 18(5):1649-53. PubMed ID: 18249539
[TBL] [Abstract][Full Text] [Related]
13. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.
Shearman MS; Beher D; Clarke EE; Lewis HD; Harrison T; Hunt P; Nadin A; Smith AL; Stevenson G; Castro JL
Biochemistry; 2000 Aug; 39(30):8698-704. PubMed ID: 10913280
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere.
Kiso Y
Biopolymers; 1996; 40(2):235-44. PubMed ID: 8785365
[TBL] [Abstract][Full Text] [Related]
15. Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.
Kimura T; Hamada Y; Stochaj M; Ikari H; Nagamine A; Abdel-Rahman H; Igawa N; Hidaka K; Nguyen JT; Saito K; Hayashi Y; Kiso Y
Bioorg Med Chem Lett; 2006 May; 16(9):2380-6. PubMed ID: 16481167
[TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid.
Ziora Z; Kasai S; Hidaka K; Nagamine A; Kimura T; Hayashi Y; Kiso Y
Bioorg Med Chem Lett; 2007 Mar; 17(6):1629-33. PubMed ID: 17251016
[TBL] [Abstract][Full Text] [Related]
17. Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere.
Hidaka K; Kimura T; Hayashi Y; McDaniel KF; Dekhtyar T; Colletti L; Kiso Y
Bioorg Med Chem Lett; 2003 Jan; 13(1):93-6. PubMed ID: 12467624
[TBL] [Abstract][Full Text] [Related]
18. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
Asai M; Hattori C; Iwata N; Saido TC; Sasagawa N; Szabó B; Hashimoto Y; Maruyama K; Tanuma S; Kiso Y; Ishiura S
J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and gamma-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres.
Nadin A; Owens AP; Castro JL; Harrison T; Shearman MS
Bioorg Med Chem Lett; 2003 Jan; 13(1):37-41. PubMed ID: 12467612
[TBL] [Abstract][Full Text] [Related]
20. Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies.
Tamamura H; Kato T; Otaka A; Fujii N
Org Biomol Chem; 2003 Jul; 1(14):2468-73. PubMed ID: 12956063
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
