These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
105 related articles for article (PubMed ID: 14643346)
1. trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. Le Bourdonnec B; Belanger S; Cassel JA; Stabley GJ; DeHaven RN; Dolle RE Bioorg Med Chem Lett; 2003 Dec; 13(24):4459-62. PubMed ID: 14643346 [TBL] [Abstract][Full Text] [Related]
2. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Le Bourdonnec B; Barker WM; Belanger S; Wiant DD; Conway-James NC; Cassel JA; O'Neill TJ; Little PJ; DeHaven RN; DeHaven-Hudkins DL; Dolle RE Bioorg Med Chem Lett; 2008 Mar; 18(6):2006-12. PubMed ID: 18313920 [TBL] [Abstract][Full Text] [Related]
3. Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. Le Bourdonnec B; Goodman AJ; Michaut M; Ye HF; Graczyk TM; Belanger S; Herbertz T; Yap GP; DeHaven RN; Dolle RE J Med Chem; 2006 Dec; 49(25):7278-89. PubMed ID: 17149858 [TBL] [Abstract][Full Text] [Related]
4. Synthesis and structure-activity relationships of a new series of 2alpha-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as mu-selective opioid antagonists. Le Bourdonnec B; Goodman AJ; Michaut M; Ye HF; Graczyk TM; Belanger S; DeHaven RN; Dolle RE Bioorg Med Chem Lett; 2006 Feb; 16(4):864-8. PubMed ID: 16298525 [TBL] [Abstract][Full Text] [Related]
5. Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine. Thomas JB; Fall MJ; Cooper JB; Rothman RB; Mascarella SW; Xu H; Partilla JS; Dersch CM; McCullough KB; Cantrell BE; Zimmerman DM; Carroll FI J Med Chem; 1998 Dec; 41(26):5188-97. PubMed ID: 9857089 [TBL] [Abstract][Full Text] [Related]
6. Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. Thomas JB; Atkinson RN; Rothman RB; Fix SE; Mascarella SW; Vinson NA; Xu H; Dersch CM; Lu Y; Cantrell BE; Zimmerman DM; Carroll FI J Med Chem; 2001 Aug; 44(17):2687-90. PubMed ID: 11495579 [TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors. Zimmerman DM; Leander JD; Cantrell BE; Reel JK; Snoddy J; Mendelsohn LG; Johnson BG; Mitch CH J Med Chem; 1993 Oct; 36(20):2833-41. PubMed ID: 8410998 [TBL] [Abstract][Full Text] [Related]
8. Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists. Thomas JB; Mascarella SW; Rothman RB; Partilla JS; Xu H; McCullough KB; Dersch CM; Cantrell BE; Zimmerman DM; Carroll FI J Med Chem; 1998 May; 41(11):1980-90. PubMed ID: 9599247 [TBL] [Abstract][Full Text] [Related]
9. Biaryl piperidines as potent and selective delta opioid receptor ligands. Liras S; McHardy SF; Allen MP; Segelstein BE; Heck SD; Bryce DK; Schmidt AW; Vanase-Frawley M; Callegari E; McLean S Bioorg Med Chem Lett; 2010 Jan; 20(2):503-7. PubMed ID: 20015649 [TBL] [Abstract][Full Text] [Related]
10. Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Cai TB; Zou Z; Thomas JB; Brieaddy L; Navarro HA; Carroll FI J Med Chem; 2008 Mar; 51(6):1849-60. PubMed ID: 18307295 [TBL] [Abstract][Full Text] [Related]
11. Importance of phenolic address groups in opioid kappa receptor selective antagonists. Thomas JB; Fix SE; Rothman RB; Mascarella SW; Dersch CM; Cantrell BE; Zimmerman DM; Carroll FI J Med Chem; 2004 Feb; 47(4):1070-3. PubMed ID: 14761209 [TBL] [Abstract][Full Text] [Related]
12. Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist. Thomas JB; Atkinson RN; Vinson NA; Catanzaro JL; Perretta CL; Fix SE; Mascarella SW; Rothman RB; Xu H; Dersch CM; Cantrell BE; Zimmerman DM; Carroll FI J Med Chem; 2003 Jul; 46(14):3127-37. PubMed ID: 12825951 [TBL] [Abstract][Full Text] [Related]
13. Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders. Zimmerman DM; Gidda JS; Cantrell BE; Schoepp DD; Johnson BG; Leander JD J Med Chem; 1994 Jul; 37(15):2262-5. PubMed ID: 8057274 [TBL] [Abstract][Full Text] [Related]
15. Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore. Grundt P; Williams IA; Lewis JW; Husbands SM J Med Chem; 2004 Oct; 47(21):5069-75. PubMed ID: 15456250 [TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. Murali Dhar TG; Nagarathnam D; Marzabadi MR; Lagu B; Wong WC; Chiu G; Tyagarajan S; Miao SW; Zhang F; Sun W; Tian D; Shen Q; Zhang J; Wetzel JM; Forray C; Chang RS; Broten TP; Schorn TW; Chen TB; O'Malley S; Ransom R; Schneck K; Bendesky R; Harrell CM; Vyas KP J Med Chem; 1999 Nov; 42(23):4778-93. PubMed ID: 10579841 [TBL] [Abstract][Full Text] [Related]