BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 14657567)

  • 21. Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.
    Metz MZ; Gutova M; Lacey SF; Abramyants Y; Vo T; Gilchrist M; Tirughana R; Ghoda LY; Barish ME; Brown CE; Najbauer J; Potter PM; Portnow J; Synold TW; Aboody KS
    Stem Cells Transl Med; 2013 Dec; 2(12):983-92. PubMed ID: 24167321
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan.
    Tyminski E; Leroy S; Terada K; Finkelstein DM; Hyatt JL; Danks MK; Potter PM; Saeki Y; Chiocca EA
    Cancer Res; 2005 Aug; 65(15):6850-7. PubMed ID: 16061668
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.
    Wadkins RM; Morton CL; Weeks JK; Oliver L; Wierdl M; Danks MK; Potter PM
    Mol Pharmacol; 2001 Aug; 60(2):355-62. PubMed ID: 11455023
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38.
    Stubdal H; Perin N; Lemmon M; Holman P; Bauzon M; Potter PM; Danks MK; Fattaey A; Dubensky T; Johnson L
    Cancer Res; 2003 Oct; 63(20):6900-8. PubMed ID: 14583489
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.
    Hyatt JL; Tsurkan L; Wierdl M; Edwards CC; Danks MK; Potter PM
    Mol Cancer Ther; 2006 Sep; 5(9):2281-8. PubMed ID: 16985062
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Hypoxia-targeted over-expression of carboxylesterase as a means of increasing tumour sensitivity to irinotecan (CPT-11).
    Matzow T; Cowen RL; Williams KJ; Telfer BA; Flint PJ; Southgate TD; Saunders MP
    J Gene Med; 2007 Apr; 9(4):244-52. PubMed ID: 17397102
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Modifications of human carboxylesterase for improved prodrug activation.
    Hatfield JM; Wierdl M; Wadkins RM; Potter PM
    Expert Opin Drug Metab Toxicol; 2008 Sep; 4(9):1153-65. PubMed ID: 18721110
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases.
    Takayama H; Watanabe A; Hosokawa M; Chiba K; Satoh T; Aimi N
    Bioorg Med Chem Lett; 1998 Mar; 8(5):415-8. PubMed ID: 9871589
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma.
    Gutova M; Shackleford GM; Khankaldyyan V; Herrmann KA; Shi XH; Mittelholtz K; Abramyants Y; Blanchard MS; Kim SU; Annala AJ; Najbauer J; Synold TW; D'Apuzzo M; Barish ME; Moats RA; Aboody KS
    Gene Ther; 2013 Feb; 20(2):143-50. PubMed ID: 22402322
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients.
    Sai K; Saito Y; Tatewaki N; Hosokawa M; Kaniwa N; Nishimaki-Mogami T; Naito M; Sawada J; Shirao K; Hamaguchi T; Yamamoto N; Kunitoh H; Tamura T; Yamada Y; Ohe Y; Yoshida T; Minami H; Ohtsu A; Matsumura Y; Saijo N; Okuda H
    Br J Clin Pharmacol; 2010 Aug; 70(2):222-33. PubMed ID: 20653675
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug.
    Senter PD; Beam KS; Mixan B; Wahl AF
    Bioconjug Chem; 2001; 12(6):1074-80. PubMed ID: 11716702
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structural insights into CPT-11 activation by mammalian carboxylesterases.
    Bencharit S; Morton CL; Howard-Williams EL; Danks MK; Potter PM; Redinbo MR
    Nat Struct Biol; 2002 May; 9(5):337-42. PubMed ID: 11967565
    [TBL] [Abstract][Full Text] [Related]  

  • 33. An overview of the recent progress in irinotecan pharmacogenetics.
    Fujiwara Y; Minami H
    Pharmacogenomics; 2010 Mar; 11(3):391-406. PubMed ID: 20235794
    [TBL] [Abstract][Full Text] [Related]  

  • 34. In vitro activation of irinotecan to SN-38 by human liver and intestine.
    Ahmed F; Vyas V; Cornfield A; Goodin S; Ravikumar TS; Rubin EH; Gupta E
    Anticancer Res; 1999; 19(3A):2067-71. PubMed ID: 10470149
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug.
    Xiao D; Yang D; Guo L; Lu W; Charpentier M; Yan B
    Br J Pharmacol; 2013 Apr; 168(8):1989-99. PubMed ID: 23373735
    [TBL] [Abstract][Full Text] [Related]  

  • 36. [Irinotecan pharmacokinetics].
    Chabot GG; Robert J; Lokiec F; Canal P
    Bull Cancer; 1998 Dec; Spec No():11-20. PubMed ID: 9932079
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Non-linear pharmacokinetics of irinotecan in mice.
    Rouits E; Guichard S; Canal P; Chatelut E
    Anticancer Drugs; 2002 Jul; 13(6):631-5. PubMed ID: 12172509
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme.
    Gutova M; Najbauer J; Chen MY; Potter PM; Kim SU; Aboody KS
    Curr Stem Cell Res Ther; 2010 Sep; 5(3):273-6. PubMed ID: 19951251
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Expression and characterization of a human carboxylesterase 2 splice variant.
    Schiel MA; Green SL; Davis WI; Sanghani PC; Bosron WF; Sanghani SP
    J Pharmacol Exp Ther; 2007 Oct; 323(1):94-101. PubMed ID: 17636009
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Metabolism of CPT-11. Impact on activity.
    Rivory LP
    Ann N Y Acad Sci; 2000; 922():205-15. PubMed ID: 11193896
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.