175 related articles for article (PubMed ID: 14659761)
1. Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.
Chow MK; Paulson HL; Bottomley SP
J Mol Biol; 2004 Jan; 335(1):333-41. PubMed ID: 14659761
[TBL] [Abstract][Full Text] [Related]
2. Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.
Chow MK; Ellisdon AM; Cabrita LD; Bottomley SP
J Biol Chem; 2004 Nov; 279(46):47643-51. PubMed ID: 15345714
[TBL] [Abstract][Full Text] [Related]
3. Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis.
Ricchelli F; Fusi P; Tortora P; Valtorta M; Riva M; Tognon G; Chieregato K; Bolognin S; Zatta P
Int J Biochem Cell Biol; 2007; 39(5):966-77. PubMed ID: 17300980
[TBL] [Abstract][Full Text] [Related]
4. Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: trapping early oligomers of non-expanded ataxin-3.
Gales L; Cortes L; Almeida C; Melo CV; Costa MC; Maciel P; Clarke DT; Damas AM; Macedo-Ribeiro S
J Mol Biol; 2005 Oct; 353(3):642-54. PubMed ID: 16194547
[TBL] [Abstract][Full Text] [Related]
5. Misfolding promotes the ubiquitination of polyglutamine-expanded ataxin-3, the defective gene product in SCA3/MJD.
Jana NR; Nukina N
Neurotox Res; 2004; 6(7-8):523-33. PubMed ID: 15639784
[TBL] [Abstract][Full Text] [Related]
6. Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
Masino L; Nicastro G; Menon RP; Dal Piaz F; Calder L; Pastore A
J Mol Biol; 2004 Dec; 344(4):1021-35. PubMed ID: 15544810
[TBL] [Abstract][Full Text] [Related]
7. Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.
Chai Y; Koppenhafer SL; Shoesmith SJ; Perez MK; Paulson HL
Hum Mol Genet; 1999 Apr; 8(4):673-82. PubMed ID: 10072437
[TBL] [Abstract][Full Text] [Related]
8. Chemical chaperones reduce aggregate formation and cell death caused by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Yoshida H; Yoshizawa T; Shibasaki F; Shoji S; Kanazawa I
Neurobiol Dis; 2002 Jul; 10(2):88-99. PubMed ID: 12127147
[TBL] [Abstract][Full Text] [Related]
9. Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.
Ellisdon AM; Pearce MC; Bottomley SP
J Mol Biol; 2007 Apr; 368(2):595-605. PubMed ID: 17362987
[TBL] [Abstract][Full Text] [Related]
10. Ataxin-3 with an altered conformation that exposes the polyglutamine domain is associated with the nuclear matrix.
Perez MK; Paulson HL; Pittman RN
Hum Mol Genet; 1999 Dec; 8(13):2377-85. PubMed ID: 10556285
[TBL] [Abstract][Full Text] [Related]
11. Flanking domain stability modulates the aggregation kinetics of a polyglutamine disease protein.
Saunders HM; Gilis D; Rooman M; Dehouck Y; Robertson AL; Bottomley SP
Protein Sci; 2011 Oct; 20(10):1675-81. PubMed ID: 21780213
[TBL] [Abstract][Full Text] [Related]
12. Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
Berke SJ; Schmied FA; Brunt ER; Ellerby LM; Paulson HL
J Neurochem; 2004 May; 89(4):908-18. PubMed ID: 15140190
[TBL] [Abstract][Full Text] [Related]
13. Ectoine alters subcellular localization of inclusions and reduces apoptotic cell death induced by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Furusho K; Yoshizawa T; Shoji S
Neurobiol Dis; 2005 Oct; 20(1):170-8. PubMed ID: 16137577
[TBL] [Abstract][Full Text] [Related]
14. Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.
Kvam E; Nannenga BL; Wang MS; Jia Z; Sierks MR; Messer A
PLoS One; 2009 May; 4(5):e5727. PubMed ID: 19492089
[TBL] [Abstract][Full Text] [Related]
15. Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease.
Matos CA; de Macedo-Ribeiro S; Carvalho AL
Prog Neurobiol; 2011 Sep; 95(1):26-48. PubMed ID: 21740957
[TBL] [Abstract][Full Text] [Related]
16. An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
Bevivino AE; Loll PJ
Proc Natl Acad Sci U S A; 2001 Oct; 98(21):11955-60. PubMed ID: 11572942
[TBL] [Abstract][Full Text] [Related]
17. [Polyglutamine-expanded ataxin-3 is degraded by autophagy].
Xiao H; Tang J; Hu Z; Tan J; Tang B; Jiang Z
Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2010 Feb; 27(1):23-8. PubMed ID: 20140862
[TBL] [Abstract][Full Text] [Related]
18. Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Yoshizawa T; Yamagishi Y; Koseki N; Goto J; Yoshida H; Shibasaki F; Shoji S; Kanazawa I
Hum Mol Genet; 2000 Jan; 9(1):69-78. PubMed ID: 10587580
[TBL] [Abstract][Full Text] [Related]
19. Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3.
Chow MK; Mackay JP; Whisstock JC; Scanlon MJ; Bottomley SP
Biochem Biophys Res Commun; 2004 Sep; 322(2):387-94. PubMed ID: 15325242
[TBL] [Abstract][Full Text] [Related]
20. Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation.
Nozaki K; Onodera O; Takano H; Tsuji S
Neuroreport; 2001 Oct; 12(15):3357-64. PubMed ID: 11711886
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
