193 related articles for article (PubMed ID: 14660628)
1. Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle.
Liu YQ; Moibi JA; Leahy JL
J Biol Chem; 2004 Feb; 279(9):7470-5. PubMed ID: 14660628
[TBL] [Abstract][Full Text] [Related]
2. Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.
Liu YQ; Tornheim K; Leahy JL
Diabetes; 1999 Sep; 48(9):1747-53. PubMed ID: 10480604
[TBL] [Abstract][Full Text] [Related]
3. beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.
Liu YQ; Jetton TL; Leahy JL
J Biol Chem; 2002 Oct; 277(42):39163-8. PubMed ID: 12147706
[TBL] [Abstract][Full Text] [Related]
4. Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids.
Hosokawa H; Corkey BE; Leahy JL
Diabetologia; 1997 Apr; 40(4):392-7. PubMed ID: 9112015
[TBL] [Abstract][Full Text] [Related]
5. Deficiency of pyruvate dehydrogenase activity in pancreatic islets of diabetic GK rats.
Zhou YP; Ostenson CG; Ling ZC; Grill V
Endocrinology; 1995 Aug; 136(8):3546-51. PubMed ID: 7628391
[TBL] [Abstract][Full Text] [Related]
6. A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.
Zhou YP; Berggren PO; Grill V
Diabetes; 1996 May; 45(5):580-6. PubMed ID: 8621007
[TBL] [Abstract][Full Text] [Related]
7. A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
Skelly RH; Bollheimer LC; Wicksteed BL; Corkey BE; Rhodes CJ
Biochem J; 1998 Apr; 331 ( Pt 2)(Pt 2):553-61. PubMed ID: 9531497
[TBL] [Abstract][Full Text] [Related]
8. Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets.
Zhou YP; Grill VE
Diabetes; 1995 Apr; 44(4):394-9. PubMed ID: 7698506
[TBL] [Abstract][Full Text] [Related]
9. Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway.
Liu YQ; Han J; Epstein PN; Long YS
Am J Physiol Endocrinol Metab; 2005 Mar; 288(3):E471-8. PubMed ID: 15507531
[TBL] [Abstract][Full Text] [Related]
10. Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content.
Liu YQ; Tornheim K; Leahy JL
J Clin Invest; 1998 May; 101(9):1870-5. PubMed ID: 9576750
[TBL] [Abstract][Full Text] [Related]
11. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.
Antinozzi PA; Segall L; Prentki M; McGarry JD; Newgard CB
J Biol Chem; 1998 Jun; 273(26):16146-54. PubMed ID: 9632669
[TBL] [Abstract][Full Text] [Related]
12. Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.
Patanè G; Anello M; Piro S; Vigneri R; Purrello F; Rabuazzo AM
Diabetes; 2002 Sep; 51(9):2749-56. PubMed ID: 12196468
[TBL] [Abstract][Full Text] [Related]
13. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.
Zhou YP; Grill V
J Clin Endocrinol Metab; 1995 May; 80(5):1584-90. PubMed ID: 7745004
[TBL] [Abstract][Full Text] [Related]
14. Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling.
Noel RJ; Antinozzi PA; McGarry JD; Newgard CB
J Biol Chem; 1997 Jul; 272(30):18621-7. PubMed ID: 9228030
[TBL] [Abstract][Full Text] [Related]
15. Fasting and decreased B cell sensitivity: important role for fatty acid-induced inhibition of PDH activity.
Zhou YP; Priestman DA; Randle PJ; Grill VE
Am J Physiol; 1996 Jun; 270(6 Pt 1):E988-94. PubMed ID: 8764183
[TBL] [Abstract][Full Text] [Related]
16. Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets.
Nicholls LI; Ainscow EK; Rutter GA
Biochem Biophys Res Commun; 2002 Mar; 291(4):1081-8. PubMed ID: 11866475
[TBL] [Abstract][Full Text] [Related]
17. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion.
MacDonald MJ
J Biol Chem; 1995 Aug; 270(34):20051-8. PubMed ID: 7650022
[TBL] [Abstract][Full Text] [Related]
18. Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling.
Brun T; Roche E; Assimacopoulos-Jeannet F; Corkey BE; Kim KH; Prentki M
Diabetes; 1996 Feb; 45(2):190-8. PubMed ID: 8549864
[TBL] [Abstract][Full Text] [Related]
19. Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets.
Fransson U; Rosengren AH; Schuit FC; Renström E; Mulder H
Diabetologia; 2006 Jul; 49(7):1578-86. PubMed ID: 16752176
[TBL] [Abstract][Full Text] [Related]
20. Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake.
Small L; Brandon AE; Quek LE; Krycer JR; James DE; Turner N; Cooney GJ
Am J Physiol Endocrinol Metab; 2018 Aug; 315(2):E258-E266. PubMed ID: 29406780
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]