BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 14667224)

  • 1. Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.
    Nagarajan M; Xiao X; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Med Chem; 2003 Dec; 46(26):5712-24. PubMed ID: 14667224
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.
    Nagarajan M; Morrell A; Fort BC; Meckley MR; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Med Chem; 2004 Nov; 47(23):5651-61. PubMed ID: 15509164
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
    Fox BM; Xiao X; Antony S; Kohlhagen G; Pommier Y; Staker BL; Stewart L; Cushman M
    J Med Chem; 2003 Jul; 46(15):3275-82. PubMed ID: 12852757
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline.
    Xiao X; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Org Chem; 2004 Oct; 69(22):7495-501. PubMed ID: 15497974
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3659-63. PubMed ID: 15203138
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.
    Cushman M; Jayaraman M; Vroman JA; Fukunaga AK; Fox BM; Kohlhagen G; Strumberg D; Pommier Y
    J Med Chem; 2000 Oct; 43(20):3688-98. PubMed ID: 11020283
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors.
    Xiao X; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem; 2004 Oct; 12(19):5147-60. PubMed ID: 15351398
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures.
    Morrell A; Placzek MS; Steffen JD; Antony S; Agama K; Pommier Y; Cushman M
    J Med Chem; 2007 May; 50(9):2040-8. PubMed ID: 17402722
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.
    Ioanoviciu A; Antony S; Pommier Y; Staker BL; Stewart L; Cushman M
    J Med Chem; 2005 Jul; 48(15):4803-14. PubMed ID: 16033260
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles.
    Nagarajan M; Morrell A; Ioanoviciu A; Antony S; Kohlhagen G; Agama K; Hollingshead M; Pommier Y; Cushman M
    J Med Chem; 2006 Oct; 49(21):6283-9. PubMed ID: 17034134
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
    Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
    J Med Chem; 1999 Feb; 42(3):446-57. PubMed ID: 9986716
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.
    Morrell A; Placzek M; Parmley S; Antony S; Dexheimer TS; Pommier Y; Cushman M
    J Med Chem; 2007 Sep; 50(18):4419-30. PubMed ID: 17696418
    [TBL] [Abstract][Full Text] [Related]  

  • 13. On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.
    Xiao X; Antony S; Pommier Y; Cushman M
    J Med Chem; 2005 May; 48(9):3231-8. PubMed ID: 15857129
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors.
    Morrell A; Placzek M; Parmley S; Grella B; Antony S; Pommier Y; Cushman M
    J Med Chem; 2007 Sep; 50(18):4388-404. PubMed ID: 17676830
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and cytotoxic activity of polyamine analogues of camptothecin.
    Dallavalle S; Giannini G; Alloatti D; Casati A; Marastoni E; Musso L; Merlini L; Morini G; Penco S; Pisano C; Tinelli S; De Cesare M; Beretta GL; Zunino F
    J Med Chem; 2006 Aug; 49(17):5177-86. PubMed ID: 16913706
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Med Chem; 2006 Dec; 49(26):7740-53. PubMed ID: 17181156
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.
    Ryckebusch A; Garcin D; Lansiaux A; Goossens JF; Baldeyrou B; Houssin R; Bailly C; Hénichart JP
    J Med Chem; 2008 Jun; 51(12):3617-29. PubMed ID: 18507368
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
    Morrell A; Jayaraman M; Nagarajan M; Fox BM; Meckley MR; Ioanoviciu A; Pommier Y; Antony S; Hollingshead M; Cushman M
    Bioorg Med Chem Lett; 2006 Aug; 16(16):4395-9. PubMed ID: 16750365
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.
    Nagarajan M; Morrell A; Antony S; Kohlhagen G; Agama K; Pommier Y; Ragazzon PA; Garbett NC; Chaires JB; Hollingshead M; Cushman M
    J Med Chem; 2006 Aug; 49(17):5129-40. PubMed ID: 16913702
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors.
    Zhang X; Wang R; Zhao L; Lu N; Wang J; You Q; Li Z; Guo Q
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1276-81. PubMed ID: 22079759
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.