211 related articles for article (PubMed ID: 14685775)
1. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity.
Baumann RP; Shyam K; Penketh PG; Remack JS; Brent TP; Sartorelli AC
Cancer Chemother Pharmacol; 2004 Apr; 53(4):288-95. PubMed ID: 14685775
[TBL] [Abstract][Full Text] [Related]
2. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition.
Penketh PG; Shyam K; Baumann RP; Remack JS; Brent TP; Sartorelli AC
Cancer Chemother Pharmacol; 2004 Apr; 53(4):279-87. PubMed ID: 14704831
[TBL] [Abstract][Full Text] [Related]
3. The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation.
Baumann RP; Seow HA; Shyam K; Penketh PG; Sartorelli AC
Oncol Res; 2005; 15(6):313-25. PubMed ID: 16408696
[TBL] [Abstract][Full Text] [Related]
4. Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine.
Ishiguro K; Shyam K; Penketh PG; Sartorelli AC
Mol Cancer Ther; 2005 Nov; 4(11):1755-63. PubMed ID: 16275997
[TBL] [Abstract][Full Text] [Related]
5. Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine.
Ishiguro K; Seow HA; Penketh PG; Shyam K; Sartorelli AC
Mol Cancer Ther; 2006 Apr; 5(4):969-76. PubMed ID: 16648568
[TBL] [Abstract][Full Text] [Related]
6. Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance.
Baumann RP; Penketh PG; Ishiguro K; Shyam K; Zhu YL; Sartorelli AC
Biochem Pharmacol; 2010 Jun; 79(11):1553-61. PubMed ID: 20005211
[TBL] [Abstract][Full Text] [Related]
7. KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.
Baumann RP; Ishiguro K; Penketh PG; Shyam K; Zhu R; Sartorelli AC
Biochem Pharmacol; 2011 May; 81(10):1201-10. PubMed ID: 21396917
[TBL] [Abstract][Full Text] [Related]
8. Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.
Rice KP; Penketh PG; Shyam K; Sartorelli AC
Biochem Pharmacol; 2005 May; 69(10):1463-72. PubMed ID: 15857610
[TBL] [Abstract][Full Text] [Related]
9. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
Loktionova NA; Xu-Welliver M; Crone TM; Kanugula S; Pegg AE
Biochem Pharmacol; 1999 Jul; 58(2):237-44. PubMed ID: 10423163
[TBL] [Abstract][Full Text] [Related]
10. DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors.
Kuo CC; Liu JF; Chang JY
J Pharmacol Exp Ther; 2006 Feb; 316(2):946-54. PubMed ID: 16258022
[TBL] [Abstract][Full Text] [Related]
11. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
Dolan ME; Pegg AE; Hora NK; Erickson LC
Cancer Res; 1988 Jul; 48(13):3603-6. PubMed ID: 2837318
[TBL] [Abstract][Full Text] [Related]
12. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
Loktionova NA; Pegg AE
Cancer Res; 1996 Apr; 56(7):1578-83. PubMed ID: 8603405
[TBL] [Abstract][Full Text] [Related]
13. Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
Friedman HS; Pegg AE; Johnson SP; Loktionova NA; Dolan ME; Modrich P; Moschel RC; Struck R; Brent TP; Ludeman S; Bullock N; Kilborn C; Keir S; Dong Q; Bigner DD; Colvin OM
Cancer Chemother Pharmacol; 1999; 43(1):80-5. PubMed ID: 9923545
[TBL] [Abstract][Full Text] [Related]
14. Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Dolan ME; Norbeck L; Clyde C; Hora NK; Erickson LC; Pegg AE
Carcinogenesis; 1989 Sep; 10(9):1613-9. PubMed ID: 2766456
[TBL] [Abstract][Full Text] [Related]
15. Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Cai Y; Wu MH; Xu-Welliver M; Pegg AE; Ludeman SM; Dolan ME
Cancer Res; 2000 Oct; 60(19):5464-9. PubMed ID: 11034089
[TBL] [Abstract][Full Text] [Related]
16. Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
Ishiguro K; Zhu YL; Shyam K; Penketh PG; Baumann RP; Sartorelli AC
Biochem Pharmacol; 2010 Nov; 80(9):1317-25. PubMed ID: 20654586
[TBL] [Abstract][Full Text] [Related]
17. Strand- and sequence-specific attenuation of N-methyl-N'-nitro-N-nitrosoguanidine-induced G.C to A.T transitions by expression of human 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells.
Yang JL; Hsieh FP; Lee PC; Tseng HJ
Cancer Res; 1994 Jul; 54(14):3857-63. PubMed ID: 8033107
[TBL] [Abstract][Full Text] [Related]
18. 4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.
Zhu R; Liu MC; Luo MZ; Penketh PG; Baumann RP; Shyam K; Sartorelli AC
J Med Chem; 2011 Nov; 54(21):7720-8. PubMed ID: 21955333
[TBL] [Abstract][Full Text] [Related]
19. Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.
Zhu R; Baumann RP; Patridge E; Penketh PG; Shyam K; Ishiguro K; Sartorelli AC
Bioorg Med Chem Lett; 2013 Mar; 23(6):1853-9. PubMed ID: 23395657
[TBL] [Abstract][Full Text] [Related]
20. Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
Hansen RJ; Nagasubramanian R; Delaney SM; Cherian MM; Lin S; Kogan SC; Dolan ME
J Pharmacol Exp Ther; 2005 Dec; 315(3):1247-55. PubMed ID: 16126841
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
