BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 14697781)

  • 1. Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study.
    Hamada Y; Matsumoto H; Yamaguchi S; Kimura T; Hayashi Y; Kiso Y
    Bioorg Med Chem; 2004 Jan; 12(1):159-70. PubMed ID: 14697781
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration.
    Hamada Y; Ohtake J; Sohma Y; Kimura T; Hayashi Y; Kiso Y
    Bioorg Med Chem; 2002 Dec; 10(12):4155-67. PubMed ID: 12413869
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.
    Sohma Y; Hayashi Y; Ito T; Matsumoto H; Kimura T; Kiso Y
    J Med Chem; 2003 Sep; 46(19):4124-35. PubMed ID: 12954064
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of the acyl groups on O-->N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor.
    Hamada Y; Matsumoto H; Kimura T; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2003 Aug; 13(16):2727-30. PubMed ID: 12873502
    [TBL] [Abstract][Full Text] [Related]  

  • 5. O-N intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides.
    Sohma Y; Hayashi Y; Skwarczynski M; Hamada Y; Sasaki M; Kimura T; Kiso Y
    Biopolymers; 2004; 76(4):344-56. PubMed ID: 15386265
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Controlled drug release: new water-soluble prodrugs of an HIV protease inhibitor.
    Matsumoto H; Sohma Y; Kimura T; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2001 Feb; 11(4):605-9. PubMed ID: 11229781
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine.
    Mimoto T; Kato R; Takaku H; Nojima S; Terashima K; Misawa S; Fukazawa T; Ueno T; Sato H; Shintani M; Kiso Y; Hayashi H
    J Med Chem; 1999 May; 42(10):1789-802. PubMed ID: 10346931
    [TBL] [Abstract][Full Text] [Related]  

  • 8. O-N intramolecular acyl migration strategy in water-soluble prodrugs of taxoids.
    Skwarczynski M; Sohma Y; Kimura M; Hayashi Y; Kimura T; Kiso Y
    Bioorg Med Chem Lett; 2003 Dec; 13(24):4441-4. PubMed ID: 14643342
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor.
    Agarwal S; Boddu SH; Jain R; Samanta S; Pal D; Mitra AK
    Int J Pharm; 2008 Jul; 359(1-2):7-14. PubMed ID: 18455890
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of prodrug-type anti-HIV agents: ester conjugates of carboxylic acid-containing dipeptide HIV protease inhibitors and a reverse transcriptase inhibitor.
    Matsumoto H; Matsuda T; Nakata S; Mitoguchi T; Kimura T; Hayashi Y; Kiso Y
    Bioorg Med Chem; 2001 Feb; 9(2):417-30. PubMed ID: 11249134
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
    A M Subbaiah M; Mandlekar S; Desikan S; Ramar T; Subramani L; Annadurai M; Desai SD; Sinha S; Jenkins SM; Krystal MR; Subramanian M; Sridhar S; Padmanabhan S; Bhutani P; Arla R; Singh S; Sinha J; Thakur M; Kadow JF; Meanwell NA
    J Med Chem; 2019 Apr; 62(7):3553-3574. PubMed ID: 30938524
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility.
    Mahfouz NM; Hassan MA
    J Pharm Pharmacol; 2001 Jun; 53(6):841-8. PubMed ID: 11428660
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel prodrugs with a spontaneous cleavable guanidine moiety.
    Hamada Y
    Bioorg Med Chem Lett; 2016 Apr; 26(7):1685-9. PubMed ID: 26923694
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Application of the O-N intramolecular acyl migration reaction in medicinal chemistry.
    Skwarczynski M; Kiso Y
    Curr Med Chem; 2007; 14(26):2813-23. PubMed ID: 18045127
    [TBL] [Abstract][Full Text] [Related]  

  • 15. No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids: scope and limitation of O-N intramolecular acyl and acyloxy migration reactions.
    Skwarczynski M; Sohma Y; Noguchi M; Kimura M; Hayashi Y; Hamada Y; Kimura T; Kiso Y
    J Med Chem; 2005 Apr; 48(7):2655-66. PubMed ID: 15801856
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel prodrug approach to amprenavir-based HIV-1 protease inhibitors via O-->N acyloxy migration of P1 moiety.
    Kazmierski WM; Bevans P; Furfine E; Spaltenstein A; Yang H
    Bioorg Med Chem Lett; 2003 Aug; 13(15):2523-6. PubMed ID: 12852957
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Kinetics of degradation and oil solubility of ester prodrugs of a model dipeptide (Gly-Phe).
    Larsen SW; Ankersen M; Larsen C
    Eur J Pharm Sci; 2004 Aug; 22(5):399-408. PubMed ID: 15265509
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and anti-HIV activity of glucose-containing prodrugs derived from saquinavir, indinavir and nelfinavir.
    Rouquayrol M; Gaucher B; Greiner J; Aubertin AM; Vierling P; Guedj R
    Carbohydr Res; 2001 Nov; 336(3):161-80. PubMed ID: 11705466
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir.
    DeGoey DA; Grampovnik DJ; Flosi WJ; Marsh KC; Wang XC; Klein LL; McDaniel KF; Liu Y; Long MA; Kati WM; Molla A; Kempf DJ
    J Med Chem; 2009 May; 52(9):2964-70. PubMed ID: 19348416
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Water-soluble prodrugs of an Aurora kinase inhibitor.
    Oslob JD; Heumann SA; Yu CH; Allen DA; Baskaran S; Bui M; Delarosa E; Fung AD; Hashash A; Hau J; Ivy S; Jacobs JW; Lew W; Maung J; McDowell RS; Ritchie S; Romanowski MJ; Silverman JA; Yang W; Zhong M; Fuchs-Knotts T
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1409-12. PubMed ID: 19186057
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.