BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

246 related articles for article (PubMed ID: 14699101)

  • 1. Physicochemical features of the HERG channel drug binding site.
    Fernandez D; Ghanta A; Kauffman GW; Sanguinetti MC
    J Biol Chem; 2004 Mar; 279(11):10120-7. PubMed ID: 14699101
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.
    Chen J; Seebohm G; Sanguinetti MC
    Proc Natl Acad Sci U S A; 2002 Sep; 99(19):12461-6. PubMed ID: 12209010
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.
    Sănchez-Chapula JA; Ferrer T; Navarro-Polanco RA; Sanguinetti MC
    Mol Pharmacol; 2003 May; 63(5):1051-8. PubMed ID: 12695533
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A structural basis for drug-induced long QT syndrome.
    Mitcheson JS; Chen J; Lin M; Culberson C; Sanguinetti MC
    Proc Natl Acad Sci U S A; 2000 Oct; 97(22):12329-33. PubMed ID: 11005845
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.
    Sanguinetti MC; Chen J; Fernandez D; Kamiya K; Mitcheson J; Sanchez-Chapula JA
    Novartis Found Symp; 2005; 266():159-66; discussion 166-70. PubMed ID: 16050267
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block.
    Sánchez-Chapula JA; Navarro-Polanco RA; Culberson C; Chen J; Sanguinetti MC
    J Biol Chem; 2002 Jun; 277(26):23587-95. PubMed ID: 11960982
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
    Ficker E; Obejero-Paz CA; Zhao S; Brown AM
    J Biol Chem; 2002 Feb; 277(7):4989-98. PubMed ID: 11741928
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular determinants of hERG channel block by terfenadine and cisapride.
    Kamiya K; Niwa R; Morishima M; Honjo H; Sanguinetti MC
    J Pharmacol Sci; 2008 Nov; 108(3):301-7. PubMed ID: 18987434
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural determinants of HERG channel block by clofilium and ibutilide.
    Perry M; de Groot MJ; Helliwell R; Leishman D; Tristani-Firouzi M; Sanguinetti MC; Mitcheson J
    Mol Pharmacol; 2004 Aug; 66(2):240-9. PubMed ID: 15266014
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel.
    Fan JS; Jiang M; Dun W; McDonald TV; Tseng GN
    Biophys J; 1999 Jun; 76(6):3128-40. PubMed ID: 10354437
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines.
    Taglialatela M; Pannaccione A; Castaldo P; Giorgio G; Zhou Z; January CT; Genovese A; Marone G; Annunziato L
    Mol Pharmacol; 1998 Jul; 54(1):113-21. PubMed ID: 9658196
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.
    Scherer CR; Lerche C; Decher N; Dennis AT; Maier P; Ficker E; Busch AE; Wollnik B; Steinmeyer K
    Br J Pharmacol; 2002 Nov; 137(6):892-900. PubMed ID: 12411421
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
    Spector PS; Curran ME; Keating MT; Sanguinetti MC
    Circ Res; 1996 Mar; 78(3):499-503. PubMed ID: 8593709
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular determinants of dofetilide block of HERG K+ channels.
    Ficker E; Jarolimek W; Kiehn J; Baumann A; Brown AM
    Circ Res; 1998 Feb; 82(3):386-95. PubMed ID: 9486667
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.
    Rampe D; Roy ML; Dennis A; Brown AM
    FEBS Lett; 1997 Nov; 417(1):28-32. PubMed ID: 9395068
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.
    Mitcheson JS; Chen J; Sanguinetti MC
    J Gen Physiol; 2000 Mar; 115(3):229-40. PubMed ID: 10694252
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Open channel block of HERG K(+) channels by vesnarinone.
    Kamiya K; Mitcheson JS; Yasui K; Kodama I; Sanguinetti MC
    Mol Pharmacol; 2001 Aug; 60(2):244-53. PubMed ID: 11455010
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule.
    Pardo-Lopez L; Zhang M; Liu J; Jiang M; Possani LD; Tseng GN
    J Biol Chem; 2002 May; 277(19):16403-11. PubMed ID: 11864985
    [TBL] [Abstract][Full Text] [Related]  

  • 19. An amino acid residue whose change by mutation affects drug binding to the HERG channel.
    Ishii K; Kondo K; Takahashi M; Kimura M; Endoh M
    FEBS Lett; 2001 Oct; 506(3):191-5. PubMed ID: 11602243
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole.
    Suessbrich H; Waldegger S; Lang F; Busch AE
    FEBS Lett; 1996 Apr; 385(1-2):77-80. PubMed ID: 8641472
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.