BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

735 related articles for article (PubMed ID: 14701857)

  • 1. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    Koivunen P; Hirsilä M; Günzler V; Kivirikko KI; Myllyharju J
    J Biol Chem; 2004 Mar; 279(11):9899-904. PubMed ID: 14701857
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway.
    Dann CE; Bruick RK; Deisenhofer J
    Proc Natl Acad Sci U S A; 2002 Nov; 99(24):15351-6. PubMed ID: 12432100
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH).
    Flagg SC; Martin CB; Taabazuing CY; Holmes BE; Knapp MJ
    J Inorg Biochem; 2012 Aug; 113():25-30. PubMed ID: 22687491
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.
    Linke S; Stojkoski C; Kewley RJ; Booker GW; Whitelaw ML; Peet DJ
    J Biol Chem; 2004 Apr; 279(14):14391-7. PubMed ID: 14734545
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
    Hewitson KS; McNeill LA; Riordan MV; Tian YM; Bullock AN; Welford RW; Elkins JM; Oldham NJ; Bhattacharya S; Gleadle JM; Ratcliffe PJ; Pugh CW; Schofield CJ
    J Biol Chem; 2002 Jul; 277(29):26351-5. PubMed ID: 12042299
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
    Stolze IP; Tian YM; Appelhoff RJ; Turley H; Wykoff CC; Gleadle JM; Ratcliffe PJ
    J Biol Chem; 2004 Oct; 279(41):42719-25. PubMed ID: 15302861
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.
    Li D; Hirsilä M; Koivunen P; Brenner MC; Xu L; Yang C; Kivirikko KI; Myllyharju J
    J Biol Chem; 2004 Dec; 279(53):55051-9. PubMed ID: 15485863
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of ankyrin repeat-containing proteins as substrates of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible transcription factor.
    Linke S; Hampton-Smith RJ; Peet DJ
    Methods Enzymol; 2007; 435():61-85. PubMed ID: 17998049
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.
    Metzen E; Berchner-Pfannschmidt U; Stengel P; Marxsen JH; Stolze I; Klinger M; Huang WQ; Wotzlaw C; Hellwig-Bürgel T; Jelkmann W; Acker H; Fandrey J
    J Cell Sci; 2003 Apr; 116(Pt 7):1319-26. PubMed ID: 12615973
    [TBL] [Abstract][Full Text] [Related]  

  • 10. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.
    Lando D; Peet DJ; Gorman JJ; Whelan DA; Whitelaw ML; Bruick RK
    Genes Dev; 2002 Jun; 16(12):1466-71. PubMed ID: 12080085
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
    Cockman ME; Lancaster DE; Stolze IP; Hewitson KS; McDonough MA; Coleman ML; Coles CH; Yu X; Hay RT; Ley SC; Pugh CW; Oldham NJ; Masson N; Schofield CJ; Ratcliffe PJ
    Proc Natl Acad Sci U S A; 2006 Oct; 103(40):14767-72. PubMed ID: 17003112
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.
    Tarhonskaya H; Hardy AP; Howe EA; Loik ND; Kramer HB; McCullagh JS; Schofield CJ; Flashman E
    J Biol Chem; 2015 Aug; 290(32):19726-42. PubMed ID: 26112411
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
    Strowitzki MJ; Cummins EP; Taylor CT
    Cells; 2019 Apr; 8(5):. PubMed ID: 31035491
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
    Flashman E; Davies SL; Yeoh KK; Schofield CJ
    Biochem J; 2010 Mar; 427(1):135-42. PubMed ID: 20055761
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.
    Koivunen P; Hirsilä M; Kivirikko KI; Myllyharju J
    J Biol Chem; 2006 Sep; 281(39):28712-20. PubMed ID: 16885164
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.
    Pappalardi MB; McNulty DE; Martin JD; Fisher KE; Jiang Y; Burns MC; Zhao H; Ho T; Sweitzer S; Schwartz B; Annan RS; Copeland RA; Tummino PJ; Luo L
    Biochem J; 2011 Jun; 436(2):363-9. PubMed ID: 21410436
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.
    Koivunen P; Hirsilä M; Remes AM; Hassinen IE; Kivirikko KI; Myllyharju J
    J Biol Chem; 2007 Feb; 282(7):4524-4532. PubMed ID: 17182618
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
    Hewitson KS; Schofield CJ; Ratcliffe PJ
    Methods Enzymol; 2007; 435():25-42. PubMed ID: 17998047
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.
    Wu Y; Li Z; McDonough MA; Schofield CJ; Zhang X
    J Med Chem; 2021 Jun; 64(11):7189-7209. PubMed ID: 34029087
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Selective inhibition of factor inhibiting hypoxia-inducible factor.
    McDonough MA; McNeill LA; Tilliet M; Papamicaël CA; Chen QY; Banerji B; Hewitson KS; Schofield CJ
    J Am Chem Soc; 2005 Jun; 127(21):7680-1. PubMed ID: 15913349
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 37.