148 related articles for article (PubMed ID: 14715467)
1. Characterization and localization of cytochrome P450 mediated metabolism of MPTP to nor-MPTP in mouse brain: relevance to Parkinson's disease.
Upadhya SC; Boyd MR; Ravindranath V
Neurotox Res; 2001 Aug; 3(4):369-80. PubMed ID: 14715467
[TBL] [Abstract][Full Text] [Related]
2. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease.
Coleman T; Ellis SW; Martin IJ; Lennard MS; Tucker GT
J Pharmacol Exp Ther; 1996 May; 277(2):685-90. PubMed ID: 8627546
[TBL] [Abstract][Full Text] [Related]
3. Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain.
Chinta SJ; Pai HV; Upadhya SC; Boyd MR; Ravindranath V
Brain Res Mol Brain Res; 2002 Jun; 103(1-2):49-61. PubMed ID: 12106691
[TBL] [Abstract][Full Text] [Related]
4. Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.
Gilham DE; Cairns W; Paine MJ; Modi S; Poulsom R; Roberts GC; Wolf CR
Xenobiotica; 1997 Jan; 27(1):111-25. PubMed ID: 9041683
[TBL] [Abstract][Full Text] [Related]
5. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.
Singh S; Singh K; Patel DK; Singh C; Nath C; Singh VK; Singh RK; Singh MP
Rejuvenation Res; 2009 Jun; 12(3):185-97. PubMed ID: 19594327
[TBL] [Abstract][Full Text] [Related]
6. The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.
Jenner P; Marsden CD
J Neural Transm Suppl; 1986; 20():11-39. PubMed ID: 3091760
[TBL] [Abstract][Full Text] [Related]
7. Histochemistry of MPTP oxidation in the rat brain: sites of synthesis of the parkinsonism-inducing toxin MPP+.
Nakamura S; Vincent SR
Neurosci Lett; 1986 Apr; 65(3):321-5. PubMed ID: 3487052
[TBL] [Abstract][Full Text] [Related]
8. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.
Saporito MS; Brown EM; Miller MS; Carswell S
J Pharmacol Exp Ther; 1999 Feb; 288(2):421-7. PubMed ID: 9918541
[TBL] [Abstract][Full Text] [Related]
9. Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).
Uehara S; Uno Y; Inoue T; Murayama N; Shimizu M; Sasaki E; Yamazaki H
Drug Metab Dispos; 2015 May; 43(5):735-42. PubMed ID: 25735838
[TBL] [Abstract][Full Text] [Related]
10. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse.
German DC; Nelson EL; Liang CL; Speciale SG; Sinton CM; Sonsalla PK
Neurodegeneration; 1996 Dec; 5(4):299-312. PubMed ID: 9117541
[TBL] [Abstract][Full Text] [Related]
11. Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins.
Kanagaraj N; Beiping H; Dheen ST; Tay SS
Neuroscience; 2014 Jul; 272():167-79. PubMed ID: 24792712
[TBL] [Abstract][Full Text] [Related]
12. MPTP-induced model of Parkinson's disease in cytochrome P450 2E1 knockout mice.
Viaggi C; Vaglini F; Pardini C; Caramelli A; Corsini GU
Neuropharmacology; 2009 Jun; 56(8):1075-81. PubMed ID: 19298832
[TBL] [Abstract][Full Text] [Related]
13. Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson's disease mouse model.
Li H; Park G; Bae N; Kim J; Oh MS; Yang HO
J Ethnopharmacol; 2015 Dec; 176():336-44. PubMed ID: 26593210
[TBL] [Abstract][Full Text] [Related]
14. Acute Restraint Stress Augments 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity via Increased Toxin Uptake into the Brain in C57BL/6 Mice.
Mitsumoto Y; Mori A
Neurosci Bull; 2018 Oct; 34(5):849-853. PubMed ID: 29987518
[TBL] [Abstract][Full Text] [Related]
15. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
Herraiz T; Guillén H; Arán VJ; Idle JR; Gonzalez FJ
Toxicol Appl Pharmacol; 2006 Nov; 216(3):387-98. PubMed ID: 16870220
[TBL] [Abstract][Full Text] [Related]
16. Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra.
Ricaurte GA; Irwin I; Forno LS; DeLanney LE; Langston E; Langston JW
Brain Res; 1987 Feb; 403(1):43-51. PubMed ID: 3493827
[TBL] [Abstract][Full Text] [Related]
17. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.
Przedborski S; Kostic V; Jackson-Lewis V; Naini AB; Simonetti S; Fahn S; Carlson E; Epstein CJ; Cadet JL
J Neurosci; 1992 May; 12(5):1658-67. PubMed ID: 1578260
[TBL] [Abstract][Full Text] [Related]
18. Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me-MPTP.
Kindt MV; Youngster SK; Sonsalla PK; Duvoisin RC; Heikkila RE
Eur J Pharmacol; 1988 Feb; 146(2-3):313-8. PubMed ID: 3131149
[TBL] [Abstract][Full Text] [Related]
19. Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson's disease.
Depboylu C; Rösler TW; de Andrade A; Oertel WH; Höglinger GU
J Neurochem; 2015 May; 133(4):590-7. PubMed ID: 25581060
[TBL] [Abstract][Full Text] [Related]
20. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibits proton motive force in energized liver mitochondria.
Singh Y; Bhatnagar R; Sidhu GS; Batra JK; Krishna G
Arch Biochem Biophys; 1989 May; 271(1):217-22. PubMed ID: 2540715
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
