BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 14723951)

  • 1. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay.
    Zhang HZ; Kasibhatla S; Wang Y; Herich J; Guastella J; Tseng B; Drewe J; Cai SX
    Bioorg Med Chem; 2004 Jan; 12(2):309-17. PubMed ID: 14723951
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Studies on chemical modification and biology of a natural product, gambogic acid (II): Synthesis and bioevaluation of gambogellic acid and its derivatives from gambogic acid as antitumor agents.
    Wang J; Ma J; You Q; Zhao L; Wang F; Li C; Guo Q
    Eur J Med Chem; 2010 Sep; 45(9):4343-53. PubMed ID: 20605273
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a Highly Potent and Novel Gambogic Acid Derivative as an Anticancer Drug Candidate.
    Ling H; Li H; Chen M; Lai B; Zhou H; Gao H; Zhang J; Huang Y; Tao Y
    Anticancer Agents Med Chem; 2021; 21(9):1110-1119. PubMed ID: 32268871
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Studies on chemical structure modification and biology of a natural product, gambogic acid (I): Synthesis and biological evaluation of oxidized analogues of gambogic acid.
    Wang J; Zhao L; Hu Y; Guo Q; Zhang L; Wang X; Li N; You Q
    Eur J Med Chem; 2009 Jun; 44(6):2611-20. PubMed ID: 18996626
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity.
    Wang X; Lu N; Yang Q; Gong D; Lin C; Zhang S; Xi M; Gao Y; Wei L; Guo Q; You Q
    Eur J Med Chem; 2011 Apr; 46(4):1280-90. PubMed ID: 21334116
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Studies on chemical structure modification and structure-activity relationship of derivatives of gambogic acid at C(39).
    Sun HP; Liu ZL; Xue X; Gao Y; Zhang L; Wang JX; Guo QL; You QD
    Chem Biodivers; 2012 Aug; 9(8):1579-90. PubMed ID: 22899618
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency.
    Wu Y; Hu M; Yang L; Li X; Bian J; Jiang F; Sun H; You Q; Zhang X
    Bioorg Med Chem Lett; 2015 Jun; 25(12):2584-8. PubMed ID: 25958244
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III.
    Guo XK; Sun HP; Shen S; Sun Y; Xie FL; Tao L; Guo QL; Jiang C; You QD
    Chem Biodivers; 2013 Jan; 10(1):73-85. PubMed ID: 23341209
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.
    Kemnitzer W; Drewe J; Jiang S; Zhang H; Wang Y; Zhao J; Jia S; Herich J; Labreque D; Storer R; Meerovitch K; Bouffard D; Rej R; Denis R; Blais C; Lamothe S; Attardo G; Gourdeau H; Tseng B; Kasibhatla S; Cai SX
    J Med Chem; 2004 Dec; 47(25):6299-310. PubMed ID: 15566300
    [TBL] [Abstract][Full Text] [Related]  

  • 10. [Progress in research of the structural optimization of natural product-like Garcinia caged xanthones].
    Wang YY; Zhang XJ; Yang YR; Sun HP; You QD
    Yao Xue Xue Bao; 2014 Mar; 49(3):293-302. PubMed ID: 24961098
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.
    Sirisoma N; Kasibhatla S; Nguyen B; Pervin A; Wang Y; Claassen G; Tseng B; Drewe J; Cai SX
    Bioorg Med Chem; 2006 Dec; 14(23):7761-73. PubMed ID: 16919962
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis.
    Lyu L; Huang LQ; Huang T; Xiang W; Yuan JD; Zhang CH
    Drug Des Devel Ther; 2018; 12():743-756. PubMed ID: 29670331
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of substituted N-phenyl nicotinamides as potent inducers of apoptosis using a cell- and caspase-based high throughput screening assay.
    Cai SX; Nguyen B; Jia S; Herich J; Guastella J; Reddy S; Tseng B; Drewe J; Kasibhatla S
    J Med Chem; 2003 Jun; 46(12):2474-81. PubMed ID: 12773051
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Studies on chemical-structure modification and structure-activity relationship of gambogic acid derivatives at carbon(34).
    Zhang XJ; Li X; Yang YR; Sun HP; Gao Y; Zhang L; Wang JX; Guo QL; You QD
    Chem Biodivers; 2012 Oct; 9(10):2295-308. PubMed ID: 23081928
    [TBL] [Abstract][Full Text] [Related]  

  • 15. GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms.
    Xie H; Qin YX; Zhou YL; Tong LJ; Lin LP; Geng MY; Duan WH; Ding J
    Acta Pharmacol Sin; 2009 Mar; 30(3):346-54. PubMed ID: 19262558
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo.
    Xu X; Wu Y; Hu M; Li X; Bao Q; Bian J; You Q; Zhang X
    Sci Rep; 2016 Oct; 6():35771. PubMed ID: 27767192
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Caged Garcinia xanthones: development since 1937.
    Han QB; Xu HX
    Curr Med Chem; 2009; 16(28):3775-96. PubMed ID: 19747141
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid.
    Kuemmerle J; Jiang S; Tseng B; Kasibhatla S; Drewe J; Cai SX
    Bioorg Med Chem; 2008 Apr; 16(8):4233-41. PubMed ID: 18337106
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells.
    Tao Z; Zhou Y; Lu J; Duan W; Qin Y; He X; Lin L; Ding J
    Cancer Biol Ther; 2007 May; 6(5):691-6. PubMed ID: 17426447
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer.
    Chantarasriwong O; Milcarek AT; Morales TH; Settle AL; Rezende CO; Althufairi BD; Theodoraki MA; Alpaugh ML; Theodorakis EA
    Eur J Med Chem; 2019 Apr; 168():405-413. PubMed ID: 30831408
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.