129 related articles for article (PubMed ID: 14742742)
1. Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor.
Hoglen NC; Chen LS; Fisher CD; Hirakawa BP; Groessl T; Contreras PC
J Pharmacol Exp Ther; 2004 May; 309(2):634-40. PubMed ID: 14742742
[TBL] [Abstract][Full Text] [Related]
2. A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia.
Hoglen NC; Anselmo DM; Katori M; Kaldas M; Shen XD; Valentino KL; Lassman C; Busuttil RW; Kupiec-Weglinski JW; Farmer DG
Liver Transpl; 2007 Mar; 13(3):361-6. PubMed ID: 17318854
[TBL] [Abstract][Full Text] [Related]
3. Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.
Hoglen NC; Hirakawa BP; Fisher CD; Weeks S; Srinivasan A; Wong AM; Valentino KL; Tomaselli KJ; Bai X; Karanewsky DS; Contreras PC
J Pharmacol Exp Ther; 2001 May; 297(2):811-8. PubMed ID: 11303074
[TBL] [Abstract][Full Text] [Related]
4. First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Linton SD; Aja T; Armstrong RA; Bai X; Chen LS; Chen N; Ching B; Contreras P; Diaz JL; Fisher CD; Fritz LC; Gladstone P; Groessl T; Gu X; Herrmann J; Hirakawa BP; Hoglen NC; Jahangiri KG; Kalish VJ; Karanewsky DS; Kodandapani L; Krebs J; McQuiston J; Meduna SP; Nalley K; Robinson ED; Sayers RO; Sebring K; Spada AP; Ternansky RJ; Tomaselli KJ; Ullman BR; Valentino KL; Weeks S; Winn D; Wu JC; Yeo P; Zhang CZ
J Med Chem; 2005 Nov; 48(22):6779-82. PubMed ID: 16250635
[TBL] [Abstract][Full Text] [Related]
5. Current opinion on 3-[2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]- 4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid, an investigational drug targeting caspases and caspase-like proteases: the clinical trials in sight and recent anti-inflammatory advances.
Haddad JJ
Recent Pat Inflamm Allergy Drug Discov; 2013 Sep; 7(3):229-58. PubMed ID: 23859695
[TBL] [Abstract][Full Text] [Related]
6. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C.
Pockros PJ; Schiff ER; Shiffman ML; McHutchison JG; Gish RG; Afdhal NH; Makhviladze M; Huyghe M; Hecht D; Oltersdorf T; Shapiro DA
Hepatology; 2007 Aug; 46(2):324-9. PubMed ID: 17654603
[TBL] [Abstract][Full Text] [Related]
7. Orally-administered caspase inhibitor PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.
Ueno Y; Ohmi T; Yamamoto M; Kato N; Moriguchi Y; Kojima M; Shimozono R; Suzuki S; Matsuura T; Eda H
J Pharmacol Sci; 2007 Oct; 105(2):201-5. PubMed ID: 17928737
[TBL] [Abstract][Full Text] [Related]
8. Differential caspase-9-dependent signaling pathway between tumor necrosis factor receptor- and Fas-mediated hepatocyte apoptosis in mice.
Imao M; Nagaki M; Imose M; Moriwaki H
Liver Int; 2006 Feb; 26(1):137-46. PubMed ID: 16420519
[TBL] [Abstract][Full Text] [Related]
9. The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats.
Lee HJ; Amidon GL
Biopharm Drug Dispos; 2002 May; 23(4):131-41. PubMed ID: 12015787
[TBL] [Abstract][Full Text] [Related]
10. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.
Int J Toxicol; 2007; 26 Suppl 1():3-106. PubMed ID: 17365137
[TBL] [Abstract][Full Text] [Related]
11. Pharmacokinetic characteristics and hepatic distribution of IH-901, a novel intestinal metabolite of ginseng saponin, in rats.
Lee PS; Song TW; Sung JH; Moon DC; Song S; Chung YB
Planta Med; 2006 Feb; 72(3):204-10. PubMed ID: 16534723
[TBL] [Abstract][Full Text] [Related]
12. Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice.
Contreras JL; Vilatoba M; Eckstein C; Bilbao G; Anthony Thompson J; Eckhoff DE
Surgery; 2004 Aug; 136(2):390-400. PubMed ID: 15300206
[TBL] [Abstract][Full Text] [Related]
13. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
[TBL] [Abstract][Full Text] [Related]
14. 1alpha(OH)D3 One-alpha-hydroxy-cholecalciferol--an active vitamin D analog. Clinical studies on prophylaxis and treatment of secondary hyperparathyroidism in uremic patients on chronic dialysis.
Brandi L
Dan Med Bull; 2008 Nov; 55(4):186-210. PubMed ID: 19232159
[TBL] [Abstract][Full Text] [Related]
15. NTP toxicology and carcinogenesis studies of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) in female Harlan Sprague-Dawley rats (Gavage Studies).
National Toxicology Program
Natl Toxicol Program Tech Rep Ser; 2006 Jan; (520):4-246. PubMed ID: 16628245
[TBL] [Abstract][Full Text] [Related]
16. IDN-6556 Idun Pharmaceuticals Inc.
Poordad FF
Curr Opin Investig Drugs; 2004 Nov; 5(11):1198-204. PubMed ID: 15573871
[TBL] [Abstract][Full Text] [Related]
17. P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.
Kamath AV; Chong S; Chang M; Marathe PH
Cancer Chemother Pharmacol; 2005 Feb; 55(2):110-6. PubMed ID: 15338193
[TBL] [Abstract][Full Text] [Related]
18. Liver tissue inducible nitric oxide synthase (iNOS) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidine.
Yaylak F; Canbaz H; Caglikulekci M; Dirlik M; Tamer L; Ogetman Z; Polat Y; Kanik A; Aydin S
J Surg Res; 2008 Aug; 148(2):214-23. PubMed ID: 18222473
[TBL] [Abstract][Full Text] [Related]
19. Multiple oral dosing of ketoconazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle dogs.
Kuroha M; Shirai Y; Shimoda M
J Vet Pharmacol Ther; 2004 Oct; 27(5):355-9. PubMed ID: 15500574
[TBL] [Abstract][Full Text] [Related]
20. Antithrombotic properties of SSR182289A, a new, orally active thrombin inhibitor.
Lorrain J; Millet L; Lechaire I; Lochot S; Ferrari P; Visconte C; Sainte-Marie M; Lunven C; Berry CN; Schaeffer P; Herbert JM; O'Connor SE
J Pharmacol Exp Ther; 2003 Feb; 304(2):567-74. PubMed ID: 12538808
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
