BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 14759740)

  • 1. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Singh SK; Ray A; Wu X; Yang JM; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2004 Feb; 12(4):795-806. PubMed ID: 14759740
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
    Satyanarayana M; Feng W; Cheng L; Liu AA; Tsai YC; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2008 Aug; 16(16):7824-31. PubMed ID: 18676151
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Kerrigan JE; Li TK; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2004 Jul; 12(13):3731-42. PubMed ID: 15186859
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
    Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
    J Med Chem; 1999 Feb; 42(3):446-57. PubMed ID: 9986716
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.
    Ruchelman AL; Singh SK; Ray A; Wu XH; Yang JM; Li TK; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2003 May; 11(9):2061-73. PubMed ID: 12670657
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
    Singh SK; Ruchelman AL; Li TK; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 2003 May; 46(11):2254-7. PubMed ID: 12747798
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
    Ruchelman AL; Zhu S; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem Lett; 2004 Nov; 14(22):5585-9. PubMed ID: 15482929
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
    Spicer JA; Gamage SA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1997 Jun; 40(12):1919-29. PubMed ID: 9191970
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Terbenzimidazoles: influence of 2"-, 4-, and 5-substituents on cytotoxicity and relative potency as topoisomerase I poisons.
    Kim JS; Yu C; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 1997 Aug; 40(18):2818-24. PubMed ID: 9288163
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues.
    Emerson DL; Besterman JM; Brown HR; Evans MG; Leitner PP; Luzzio MJ; Shaffer JE; Sternbach DD; Uehling D; Vuong A
    Cancer Res; 1995 Feb; 55(3):603-9. PubMed ID: 7834631
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.
    Feng W; Satyanarayana M; Tsai YC; Liu AA; Liu LF; Lavoie EJ
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3570-2. PubMed ID: 18511275
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
    Zhu S; Ruchelman AL; Zhou N; Liu A; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2006 May; 14(9):3131-43. PubMed ID: 16412652
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.
    Ioanoviciu A; Antony S; Pommier Y; Staker BL; Stewart L; Cushman M
    J Med Chem; 2005 Jul; 48(15):4803-14. PubMed ID: 16033260
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
    Fox BM; Xiao X; Antony S; Kohlhagen G; Pommier Y; Staker BL; Stewart L; Cushman M
    J Med Chem; 2003 Jul; 46(15):3275-82. PubMed ID: 12852757
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2.
    Tseng CH; Tzeng CC; Yang CL; Lu PJ; Chen HL; Li HY; Chuang YC; Yang CN; Chen YL
    J Med Chem; 2010 Aug; 53(16):6164-79. PubMed ID: 20662543
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.
    Zhu S; Ruchelman AL; Zhou N; Liu AA; Liu LF; LaVoie EJ
    Bioorg Med Chem; 2005 Dec; 13(24):6782-94. PubMed ID: 16153852
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
    Ruchelman AL; Houghton PJ; Zhou N; Liu A; Liu LF; LaVoie EJ
    J Med Chem; 2005 Feb; 48(3):792-804. PubMed ID: 15689163
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3659-63. PubMed ID: 15203138
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.