BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

362 related articles for article (PubMed ID: 14971896)

  • 1. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
    Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
    J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Kamal A; Srinivas O; Ramulu P; Ramesh G; Kumar PP; Kumar MS
    Bioorg Med Chem; 2004 Aug; 12(16):4337-50. PubMed ID: 15265486
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
    Tiberghien AC; Evans DA; Kiakos K; Martin CR; Hartley JA; Thurston DE; Howard PW
    Bioorg Med Chem Lett; 2008 Mar; 18(6):2073-7. PubMed ID: 18272367
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.
    Smellie M; Bose DS; Thompson AS; Jenkins TC; Hartley JA; Thurston DE
    Biochemistry; 2003 Jul; 42(27):8232-9. PubMed ID: 12846572
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
    Kamal A; Ramulu P; Srinivas O; Ramesh G; Kumar PP
    Bioorg Med Chem Lett; 2004 Sep; 14(18):4791-4. PubMed ID: 15324909
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
    Thurston DE; Bose DS; Howard PW; Jenkins TC; Leoni A; Baraldi PG; Guiotto A; Cacciari B; Kelland LR; Foloppe MP; Rault S
    J Med Chem; 1999 Jun; 42(11):1951-64. PubMed ID: 10354403
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
    Antonow D; Kaliszczak M; Kang GD; Coffils M; Tiberghien AC; Cooper N; Barata T; Heidelberger S; James CH; Zloh M; Jenkins TC; Reszka AP; Neidle S; Guichard SM; Jodrell DI; Hartley JA; Howard PW; Thurston DE
    J Med Chem; 2010 Apr; 53(7):2927-41. PubMed ID: 20218628
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
    Martin C; Ellis T; McGurk CJ; Jenkins TC; Hartley JA; Waring MJ; Thurston DE
    Biochemistry; 2005 Mar; 44(11):4135-47. PubMed ID: 15766241
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
    Hartley JA; Spanswick VJ; Brooks N; Clingen PH; McHugh PJ; Hochhauser D; Pedley RB; Kelland LR; Alley MC; Schultz R; Hollingshead MG; Schweikart KM; Tomaszewski JE; Sausville EA; Gregson SJ; Howard PW; Thurston DE
    Cancer Res; 2004 Sep; 64(18):6693-9. PubMed ID: 15374986
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
    Gregson SJ; Howard PW; Hartley JA; Brooks NA; Adams LJ; Jenkins TC; Kelland LR; Thurston DE
    J Med Chem; 2001 Mar; 44(5):737-48. PubMed ID: 11262084
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis and in vitro cytotoxicity studies of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD)--polymade conjugates and 2,2'-PBD dimers.
    Reddy BS; Damayanthi Y; Reddy BS; Lown JW
    Anticancer Drug Des; 2000 Jun; 15(3):225-38. PubMed ID: 11049090
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyrrolobenzodiazepine dimers: novel sequence-selective, DNA-interactive, cross-linking agents with activity against Gram-positive bacteria.
    Hadjivassileva T; Thurston DE; Taylor PW
    J Antimicrob Chemother; 2005 Sep; 56(3):513-8. PubMed ID: 16024592
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
    Wells G; Martin CR; Howard PW; Sands ZA; Laughton CA; Tiberghien A; Woo CK; Masterson LA; Stephenson MJ; Hartley JA; Jenkins TC; Shnyder SD; Loadman PM; Waring MJ; Thurston DE
    J Med Chem; 2006 Sep; 49(18):5442-61. PubMed ID: 16942018
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity.
    Kamal A; Shankaraiah N; Devaiah V; Laxma Reddy K; Juvekar A; Sen S; Kurian N; Zingde S
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1468-73. PubMed ID: 18207392
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.
    Wilson SC; Howard PW; Forrow SM; Hartley JA; Adams LJ; Jenkins TC; Kelland LR; Thurston DE
    J Med Chem; 1999 Oct; 42(20):4028-41. PubMed ID: 10514273
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.
    Masterson LA; Croker SJ; Jenkins TC; Howard PW; Thurston DE
    Bioorg Med Chem Lett; 2004 Feb; 14(4):901-4. PubMed ID: 15012990
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Gregson SJ; Howard PW; Thurston DE
    Bioorg Med Chem Lett; 2003 Jul; 13(14):2277-80. PubMed ID: 12824017
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents.
    Kamal A; Vijaya Bharathi E; Janaki Ramaiah M; Dastagiri D; Surendranadha Reddy J; Viswanath A; Sultana F; Pushpavalli SN; Pal-Bhadra M; Srivastava HK; Narahari Sastry G; Juvekar A; Sen S; Zingde S
    Bioorg Med Chem; 2010 Jan; 18(2):526-42. PubMed ID: 20031423
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
    Howard PW; Chen Z; Gregson SJ; Masterson LA; Tiberghien AC; Cooper N; Fang M; Coffils MJ; Klee S; Hartley JA; Thurston DE
    Bioorg Med Chem Lett; 2009 Nov; 19(22):6463-6. PubMed ID: 19811912
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
    Tiberghien AC; Hagan D; Howard PW; Thurston DE
    Bioorg Med Chem Lett; 2004 Oct; 14(20):5041-4. PubMed ID: 15380195
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.