These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 14971906)

  • 1. Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.
    Guo Z; Zhu YF; Gross TD; Tucci FC; Gao Y; Moorjani M; Connors PJ; Rowbottom MW; Chen Y; Struthers RS; Xie Q; Saunders J; Reinhart G; Chen TK; Bonneville AL; Chen C
    J Med Chem; 2004 Feb; 47(5):1259-71. PubMed ID: 14971906
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.
    Zhu YF; Gross TD; Guo Z; Connors PJ; Gao Y; Tucci FC; Struthers RS; Reinhart GJ; Saunders J; Chen TK; Killam Bonneville AL; Chen C
    J Med Chem; 2003 May; 46(11):2023-6. PubMed ID: 12747774
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and structure-activity relationships of 1-arylmethyl-3-(2-aminopropyl)-5-aryl-6-methyluracils as potent GnRH receptor antagonists.
    Guo Z; Zhu YF; Tucci FC; Gao Y; Struthers RS; Saunders J; Gross TD; Xie Q; Reinhart GJ; Chen C
    Bioorg Med Chem Lett; 2003 Oct; 13(19):3311-5. PubMed ID: 12951116
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.
    Rowbottom MW; Tucci FC; Zhu YF; Guo Z; Gross TD; Reinhart GJ; Xie Q; Struthers RS; Saunders J; Chen C
    Bioorg Med Chem Lett; 2004 May; 14(9):2269-74. PubMed ID: 15081023
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.
    Tucci FC; Zhu YF; Guo Z; Gross TD; Connors PJ; Struthers RS; Reinhart GJ; Saunders J; Chen C
    Bioorg Med Chem Lett; 2003 Oct; 13(19):3317-22. PubMed ID: 12951117
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
    Zhu YF; Guo Z; Gross TD; Gao Y; Connors PJ; Struthers RS; Xie Q; Tucci FC; Reinhart GJ; Wu D; Saunders J; Chen C
    J Med Chem; 2003 Apr; 46(9):1769-72. PubMed ID: 12699396
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.
    Zhao L; Guo Z; Chen Y; Hu T; Wu D; Zhu YF; Rowbottom M; Gross TD; Tucci FC; Struthers RS; Xie Q; Chen C
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3344-9. PubMed ID: 18442905
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.
    Rowbottom MW; Tucci FC; Connors PJ; Gross TD; Zhu YF; Guo Z; Moorjani M; Acevedo O; Carter L; Sullivan SK; Xie Q; Fisher A; Struthers RS; Saunders J; Chen C
    Bioorg Med Chem Lett; 2004 Oct; 14(19):4967-73. PubMed ID: 15341961
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.
    Sullivan SK; Hoare SR; Fleck BA; Zhu YF; Heise CE; Struthers RS; Crowe PD
    Biochem Pharmacol; 2006 Sep; 72(7):838-49. PubMed ID: 16930559
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor.
    Tucci FC; Zhu YF; Guo Z; Gross TD; Connors PJ; Gao Y; Rowbottom MW; Struthers RS; Reinhart GJ; Xie Q; Chen TK; Bozigian H; Killam Bonneville AL; Fisher A; Jin L; Saunders J; Chen C
    J Med Chem; 2004 Jul; 47(14):3483-6. PubMed ID: 15214774
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.
    Guo Z; Chen Y; Huang CQ; Gross TD; Pontillo J; Rowbottom MW; Saunders J; Struthers S; Tucci FC; Xie Q; Wade W; Zhu YF; Wu D; Chen C
    Bioorg Med Chem Lett; 2005 May; 15(10):2519-22. PubMed ID: 15863308
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists.
    Lowe RF; Nelson J; Dang TN; Crowe PD; Pahuja A; McCarthy JR; Grigoriadis DE; Conlon P; Saunders J; Chen C; Szabo T; Chen TK; Bozigian H
    J Med Chem; 2005 Mar; 48(5):1540-9. PubMed ID: 15743196
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.
    Tucci FC; Zhu YF; Struthers RS; Guo Z; Gross TD; Rowbottom MW; Acevedo O; Gao Y; Saunders J; Xie Q; Reinhart GJ; Liu XJ; Ling N; Bonneville AK; Chen T; Bozigian H; Chen C
    J Med Chem; 2005 Feb; 48(4):1169-78. PubMed ID: 15715483
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.
    Chen C; Chen Y; Pontillo J; Guo Z; Huang CQ; Wu D; Madan A; Chen T; Wen J; Xie Q; Tucci FC; Rowbottom M; Zhu YF; Wade W; Saunders J; Bozigian H; Struthers RS
    Bioorg Med Chem Lett; 2008 Jun; 18(11):3301-5. PubMed ID: 18442910
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.
    Chen C; Wu D; Guo Z; Xie Q; Reinhart GJ; Madan A; Wen J; Chen T; Huang CQ; Chen M; Chen Y; Tucci FC; Rowbottom M; Pontillo J; Zhu YF; Wade W; Saunders J; Bozigian H; Struthers RS
    J Med Chem; 2008 Dec; 51(23):7478-85. PubMed ID: 19006286
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.
    Kim SM; Lee M; Lee SY; Lee SM; Kim EJ; Kim JS; Ann J; Lee J; Lee J
    Eur J Med Chem; 2018 Feb; 145():413-424. PubMed ID: 29335207
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
    Wilcoxen KM; Zhu YF; Connors PJ; Saunders J; Gross TD; Gao Y; Reinhart GJ; Struthers RS; Chen C
    Bioorg Med Chem Lett; 2002 Aug; 12(16):2179-83. PubMed ID: 12127532
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists.
    Guo Z; Wu D; Zhu YF; Tucci FC; Regan CF; Rowbottom MW; Struthers RS; Xie Q; Reijmers S; Sullivan SK; Sai Y; Chen C
    Bioorg Med Chem Lett; 2005 Aug; 15(16):3685-90. PubMed ID: 15951171
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.
    Zhu YF; Struthers RS; Connors PJ; Gao Y; Gross TD; Saunders J; Wilcoxen K; Reinhart GJ; Ling N; Chen C
    Bioorg Med Chem Lett; 2002 Feb; 12(3):399-402. PubMed ID: 11814806
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R).
    Pelletier JC; Chengalvala MV; Cottom JE; Feingold IB; Green DM; Hauze DB; Huselton CA; Jetter JW; Kopf GS; Lundquist JT; Magolda RL; Mann CW; Mehlmann JF; Rogers JF; Shanno LK; Adams WR; Tio CO; Wrobel JE
    J Med Chem; 2009 Apr; 52(7):2148-52. PubMed ID: 19271735
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.