These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 14987762)

  • 1. Validation of antibacterial mechanism of action using regulated antisense RNA expression in Staphylococcus aureus.
    Ji Y; Yin D; Fox B; Holmes DJ; Payne D; Rosenberg M
    FEMS Microbiol Lett; 2004 Feb; 231(2):177-84. PubMed ID: 14987762
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of 4-Pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (FabI) with antibacterial activity against Staphylococcus aureus.
    Takahata S; Iida M; Yoshida T; Kumura K; Kitagawa H; Hoshiko S
    J Antibiot (Tokyo); 2007 Feb; 60(2):123-8. PubMed ID: 17420562
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of antimicrobial targets using a comprehensive genomic approach.
    Yin D; Fox B; Lonetto ML; Etherton MR; Payne DJ; Holmes DJ; Rosenberg M; Ji Y
    Pharmacogenomics; 2004 Jan; 5(1):101-13. PubMed ID: 14683422
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.
    Lu H; Tonge PJ
    Acc Chem Res; 2008 Jan; 41(1):11-20. PubMed ID: 18193820
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.
    Seefeld MA; Miller WH; Newlander KA; Burgess WJ; DeWolf WE; Elkins PA; Head MS; Jakas DR; Janson CA; Keller PM; Manley PJ; Moore TD; Payne DJ; Pearson S; Polizzi BJ; Qiu X; Rittenhouse SF; Uzinskas IN; Wallis NG; Huffman WF
    J Med Chem; 2003 Apr; 46(9):1627-35. PubMed ID: 12699381
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CG400462, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor.
    Park HS; Yoon YM; Jung SJ; Yun IN; Kim CM; Kim JM; Kwak JH
    Int J Antimicrob Agents; 2007 Nov; 30(5):446-51. PubMed ID: 17723291
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Vinaxanthone, a new FabI inhibitor from Penicillium sp.
    Zheng CJ; Sohn MJ; Kim WG
    J Antimicrob Chemother; 2009 May; 63(5):949-53. PubMed ID: 19282328
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cephalochromin, a FabI-directed antibacterial of microbial origin.
    Zheng CJ; Sohn MJ; Lee S; Hong YS; Kwak JH; Kim WG
    Biochem Biophys Res Commun; 2007 Nov; 362(4):1107-12. PubMed ID: 17825252
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI.
    Kitagawa H; Kumura K; Takahata S; Iida M; Atsumi K
    Bioorg Med Chem; 2007 Jan; 15(2):1106-16. PubMed ID: 17095231
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds.
    Donald RG; Skwish S; Forsyth RA; Anderson JW; Zhong T; Burns C; Lee S; Meng X; LoCastro L; Jarantow LW; Martin J; Lee SH; Taylor I; Robbins D; Malone C; Wang L; Zamudio CS; Youngman PJ; Phillips JW
    Chem Biol; 2009 Aug; 16(8):826-36. PubMed ID: 19716473
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance.
    Protasevich II; Brouillette CG; Snow ME; Dunham S; Rubin JR; Gogliotti R; Siegel K
    Biochemistry; 2004 Oct; 43(42):13380-9. PubMed ID: 15491144
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids.
    Zheng CJ; Yoo JS; Lee TG; Cho HY; Kim YH; Kim WG
    FEBS Lett; 2005 Sep; 579(23):5157-62. PubMed ID: 16146629
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK.
    Kitagawa H; Ozawa T; Takahata S; Iida M; Saito J; Yamada M
    J Med Chem; 2007 Sep; 50(19):4710-20. PubMed ID: 17713898
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).
    Miller WH; Seefeld MA; Newlander KA; Uzinskas IN; Burgess WJ; Heerding DA; Yuan CC; Head MS; Payne DJ; Rittenhouse SF; Moore TD; Pearson SC; Berry V; DeWolf WE; Keller PM; Polizzi BJ; Qiu X; Janson CA; Huffman WF
    J Med Chem; 2002 Jul; 45(15):3246-56. PubMed ID: 12109908
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro activity of API-1252, a novel FabI inhibitor, against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis.
    Karlowsky JA; Laing NM; Baudry T; Kaplan N; Vaughan D; Hoban DJ; Zhanel GG
    Antimicrob Agents Chemother; 2007 Apr; 51(4):1580-1. PubMed ID: 17220418
    [No Abstract]   [Full Text] [Related]  

  • 16. Discovery of a novel and potent class of FabI-directed antibacterial agents.
    Payne DJ; Miller WH; Berry V; Brosky J; Burgess WJ; Chen E; DeWolf WE; Fosberry AP; Greenwood R; Head MS; Heerding DA; Janson CA; Jaworski DD; Keller PM; Manley PJ; Moore TD; Newlander KA; Pearson S; Polizzi BJ; Qiu X; Rittenhouse SF; Slater-Radosti C; Salyers KL; Seefeld MA; Smyth MG; Takata DT; Uzinskas IN; Vaidya K; Wallis NG; Winram SB; Yuan CC; Huffman WF
    Antimicrob Agents Chemother; 2002 Oct; 46(10):3118-24. PubMed ID: 12234833
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Highly sensitive target-based whole-cell antibacterial discovery strategy by antisense RNA silencing.
    Singh SB; Phillips JW; Wang J
    Curr Opin Drug Discov Devel; 2007 Mar; 10(2):160-6. PubMed ID: 17436551
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI.
    Ramnauth J; Surman MD; Sampson PB; Forrest B; Wilson J; Freeman E; Manning DD; Martin F; Toro A; Domagala M; Awrey DE; Bardouniotis E; Kaplan N; Berman J; Pauls HW
    Bioorg Med Chem Lett; 2009 Sep; 19(18):5359-62. PubMed ID: 19682900
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus.
    Forsyth A; Wang L
    Methods Mol Biol; 2008; 416():307-21. PubMed ID: 18392976
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).
    Heerding DA; Chan G; DeWolf WE; Fosberry AP; Janson CA; Jaworski DD; McManus E; Miller WH; Moore TD; Payne DJ; Qiu X; Rittenhouse SF; Slater-Radosti C; Smith W; Takata DT; Vaidya KS; Yuan CC; Huffman WF
    Bioorg Med Chem Lett; 2001 Aug; 11(16):2061-5. PubMed ID: 11514139
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.