301 related articles for article (PubMed ID: 14990463)
1. Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators.
Selz KA; Mandell AJ; Shlesinger MF; Arcuragi V; Owens MJ
Biophys J; 2004 Mar; 86(3):1308-31. PubMed ID: 14990463
[TBL] [Abstract][Full Text] [Related]
2. Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands.
Mandell AJ; Selz KA; Owens MJ; Kinkead B; Shlesinger MF; Gutman DA; Arguragi V
Neuropsychopharmacology; 2003 Jul; 28 Suppl 1():S98-107. PubMed ID: 12827150
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.
Mistry SN; Valant C; Sexton PM; Capuano B; Christopoulos A; Scammells PJ
J Med Chem; 2013 Jun; 56(12):5151-72. PubMed ID: 23718562
[TBL] [Abstract][Full Text] [Related]
4. Mode matches and their locations in the hydrophobic free energy sequences of peptide ligands and their receptor eigenfunctions.
Mandell AJ; Selz KA; Shlesinger MF
Proc Natl Acad Sci U S A; 1997 Dec; 94(25):13576-81. PubMed ID: 9391068
[TBL] [Abstract][Full Text] [Related]
5. Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.
Abdul-Ridha A; López L; Keov P; Thal DM; Mistry SN; Sexton PM; Lane JR; Canals M; Christopoulos A
J Biol Chem; 2014 Feb; 289(9):6067-79. PubMed ID: 24443568
[TBL] [Abstract][Full Text] [Related]
6. Probing the binding site of novel selective positive allosteric modulators at the M
Khajehali E; Valant C; Jörg M; Tobin AB; Conn PJ; Lindsley CW; Sexton PM; Scammells PJ; Christopoulos A
Biochem Pharmacol; 2018 Aug; 154():243-254. PubMed ID: 29777683
[TBL] [Abstract][Full Text] [Related]
7. Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.
Abdul-Ridha A; Lane JR; Mistry SN; López L; Sexton PM; Scammells PJ; Christopoulos A; Canals M
J Biol Chem; 2014 Nov; 289(48):33701-11. PubMed ID: 25326383
[TBL] [Abstract][Full Text] [Related]
8. Influence of MT7 toxin on the oligomerization state of the M1 muscarinic receptor.
Marquer C; Fruchart-Gaillard C; Mourier G; Grandjean O; Girard E; le Maire M; Brown S; Servent D
Biol Cell; 2010 Apr; 102(7):409-20. PubMed ID: 20170475
[TBL] [Abstract][Full Text] [Related]
9. Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M
van der Westhuizen ET; Spathis A; Khajehali E; Jörg M; Mistry SN; Capuano B; Tobin AB; Sexton PM; Scammells PJ; Valant C; Christopoulos A
Mol Pharmacol; 2018 Jul; 94(1):770-783. PubMed ID: 29691279
[TBL] [Abstract][Full Text] [Related]
10. Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.
Yeatman HR; Lane JR; Choy KH; Lambert NA; Sexton PM; Christopoulos A; Canals M
J Biol Chem; 2014 May; 289(22):15856-66. PubMed ID: 24753247
[TBL] [Abstract][Full Text] [Related]
11. Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism.
Kinkead B; Selz KA; Owens MJ; Mandell AJ
J Neurosci Methods; 2006 Feb; 151(1):68-81. PubMed ID: 16423408
[TBL] [Abstract][Full Text] [Related]
12. Bitopic Binding Mode of an M
Bradley SJ; Molloy C; Bundgaard C; Mogg AJ; Thompson KJ; Dwomoh L; Sanger HE; Crabtree MD; Brooke SM; Sexton PM; Felder CC; Christopoulos A; Broad LM; Tobin AB; Langmead CJ
Mol Pharmacol; 2018 Jun; 93(6):645-656. PubMed ID: 29695609
[TBL] [Abstract][Full Text] [Related]
13. Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.
Ma L; Seager MA; Wittmann M; Jacobson M; Bickel D; Burno M; Jones K; Graufelds VK; Xu G; Pearson M; McCampbell A; Gaspar R; Shughrue P; Danziger A; Regan C; Flick R; Pascarella D; Garson S; Doran S; Kreatsoulas C; Veng L; Lindsley CW; Shipe W; Kuduk S; Sur C; Kinney G; Seabrook GR; Ray WJ
Proc Natl Acad Sci U S A; 2009 Sep; 106(37):15950-5. PubMed ID: 19717450
[TBL] [Abstract][Full Text] [Related]
14. Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor.
Flohr A; Hutter R; Mueller B; Bohnert C; Pellisson M; Schaffhauser H
Bioorg Med Chem Lett; 2017 Dec; 27(24):5415-5419. PubMed ID: 29146472
[TBL] [Abstract][Full Text] [Related]
15. The pharmacologic characterization of allosteric molecules: Gq protein activation.
Bdioui S; Verdi J; Pierre N; Trinquet E; Roux T; Kenakin T
J Recept Signal Transduct Res; 2019 Apr; 39(2):106-113. PubMed ID: 31322035
[No Abstract] [Full Text] [Related]
16. Evidence for Classical Cholinergic Toxicity Associated with Selective Activation of M1 Muscarinic Receptors.
Alt A; Pendri A; Bertekap RL; Li G; Benitex Y; Nophsker M; Rockwell KL; Burford NT; Sum CS; Chen J; Herbst JJ; Ferrante M; Hendricson A; Cvijic ME; Westphal RS; O'Connell J; Banks M; Zhang L; Gentles RG; Jenkins S; Loy J; Macor JE
J Pharmacol Exp Ther; 2016 Feb; 356(2):293-304. PubMed ID: 26582730
[TBL] [Abstract][Full Text] [Related]
17. Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.
Thomas RL; Langmead CJ; Wood MD; Challiss RA
J Pharmacol Exp Ther; 2009 Dec; 331(3):1086-95. PubMed ID: 19767446
[TBL] [Abstract][Full Text] [Related]
18. Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.
Miao Y; Goldfeld DA; Moo EV; Sexton PM; Christopoulos A; McCammon JA; Valant C
Proc Natl Acad Sci U S A; 2016 Sep; 113(38):E5675-84. PubMed ID: 27601651
[TBL] [Abstract][Full Text] [Related]
19. Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.
Kuduk SD; Di Marco CN; Saffold JR; Ray WJ; Ma L; Wittmann M; Koeplinger KA; Thompson CD; Hartman GD; Bilodeau MT; Beshore DC
Bioorg Med Chem Lett; 2014 Mar; 24(5):1417-20. PubMed ID: 24485781
[TBL] [Abstract][Full Text] [Related]
20. Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor.
Grant MK; Noetzel MJ; De Lorme KC; Jakubík J; Doležal V; El-Fakahany EE
PLoS One; 2010 Dec; 5(12):e15722. PubMed ID: 21203415
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]