BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 14998341)

  • 1. Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8.
    James KE; Asgian JL; Li ZZ; Ekici OD; Rubin JR; Mikolajczyk J; Salvesen GS; Powers JC
    J Med Chem; 2004 Mar; 47(6):1553-74. PubMed ID: 14998341
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
    Ekici OD; Li ZZ; Campbell AJ; James KE; Asgian JL; Mikolajczyk J; Salvesen GS; Ganesan R; Jelakovic S; Grütter MG; Powers JC
    J Med Chem; 2006 Sep; 49(19):5728-49. PubMed ID: 16970398
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases.
    Asgian JL; James KE; Li ZZ; Carter W; Barrett AJ; Mikolajczyk J; Salvesen GS; Powers JC
    J Med Chem; 2002 Nov; 45(23):4958-60. PubMed ID: 12408706
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases).
    James KE; Götz MG; Caffrey CR; Hansell E; Carter W; Barrett AJ; McKerrow JH; Powers JC
    Biol Chem; 2003 Dec; 384(12):1613-8. PubMed ID: 14719804
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Exploring the S4 and S1 prime subsite specificities in caspase-3 with aza-peptide epoxide inhibitors.
    Ganesan R; Jelakovic S; Campbell AJ; Li ZZ; Asgian JL; Powers JC; Grütter MG
    Biochemistry; 2006 Aug; 45(30):9059-67. PubMed ID: 16866351
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Peptidyl beta-homo-aspartals (3-amino-4-carboxybutyraldehydes): new specific inhibitors of caspases.
    Bajusz S; Fauszt I; Németh K; Barabás E; Juhász A; Patthy M; Bauer PI
    Biopolymers; 1999; 51(1):109-18. PubMed ID: 10380358
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specificity of aza-peptide electrophile activity-based probes of caspases.
    Sexton KB; Kato D; Berger AB; Fonovic M; Verhelst SH; Bogyo M
    Cell Death Differ; 2007 Apr; 14(4):727-32. PubMed ID: 17170749
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
    Ekici OD; Götz MG; James KE; Li ZZ; Rukamp BJ; Asgian JL; Caffrey CR; Hansell E; Dvorák J; McKerrow JH; Potempa J; Travis J; Mikolajczyk J; Salvesen GS; Powers JC
    J Med Chem; 2004 Apr; 47(8):1889-92. PubMed ID: 15055989
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases).
    Ovat A; Muindi F; Fagan C; Brouner M; Hansell E; Dvorák J; Sojka D; Kopácek P; McKerrow JH; Caffrey CR; Powers JC
    J Med Chem; 2009 Nov; 52(22):7192-210. PubMed ID: 19848405
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and
    Corrigan TS; Lotti Diaz LM; Border SE; Ratigan SC; Kasper KQ; Sojka D; Fajtova P; Caffrey CR; Salvesen GS; McElroy CA; Hadad CM; Doğan Ekici Ö
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):1387-1402. PubMed ID: 32633155
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel aza peptide inhibitors and active-site probes of papain-family cysteine proteases.
    Verhelst SH; Witte MD; Arastu-Kapur S; Fonovic M; Bogyo M
    Chembiochem; 2006 Jun; 7(6):943-50. PubMed ID: 16607671
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
    Blanchard H; Donepudi M; Tschopp M; Kodandapani L; Wu JC; Grütter MG
    J Mol Biol; 2000 Sep; 302(1):9-16. PubMed ID: 10964557
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones.
    Niestroj AJ; Feussner K; Heiser U; Dando PM; Barrett A; Gerhartz B; Demuth HU
    Biol Chem; 2002; 383(7-8):1205-14. PubMed ID: 12437107
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors.
    Brouwer AJ; Bunschoten A; Liskamp RM
    Bioorg Med Chem; 2007 Nov; 15(22):6985-93. PubMed ID: 17869119
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3.
    Micale N; Vairagoundar R; Yakovlev AG; Kozikowski AP
    J Med Chem; 2004 Dec; 47(26):6455-8. PubMed ID: 15588079
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens.
    Götz MG; James KE; Hansell E; Dvorák J; Seshaadri A; Sojka D; Kopácek P; McKerrow JH; Caffrey CR; Powers JC
    J Med Chem; 2008 May; 51(9):2816-32. PubMed ID: 18416543
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Peptidyl epoxides extended in the P' direction as cysteine protease inhibitors: effect on affinity and mechanism of inhibition.
    Perlman N; Hazan M; Shokhen M; Albeck A
    Bioorg Med Chem; 2008 Oct; 16(19):9032-9. PubMed ID: 18789705
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cis-Configured aziridines are new pseudo-irreversible dual-mode inhibitors of Candida albicans secreted aspartic protease 2.
    Degel B; Staib P; Rohrer S; Scheiber J; Martina E; Büchold C; Baumann K; Morschhäuser J; Schirmeister T
    ChemMedChem; 2008 Feb; 3(2):302-15. PubMed ID: 18038380
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
    Becker JW; Rotonda J; Soisson SM; Aspiotis R; Bayly C; Francoeur S; Gallant M; Garcia-Calvo M; Giroux A; Grimm E; Han Y; McKay D; Nicholson DW; Peterson E; Renaud J; Roy S; Thornberry N; Zamboni R
    J Med Chem; 2004 May; 47(10):2466-74. PubMed ID: 15115390
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
    Dragovich PS; Prins TJ; Zhou R; Webber SE; Marakovits JT; Fuhrman SA; Patick AK; Matthews DA; Lee CA; Ford CE; Burke BJ; Rejto PA; Hendrickson TF; Tuntland T; Brown EL; Meador JW; Ferre RA; Harr JE; Kosa MB; Worland ST
    J Med Chem; 1999 Apr; 42(7):1213-24. PubMed ID: 10197965
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.