These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

56 related articles for article (PubMed ID: 15006135)

  • 1. Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.
    Ahn JS; Musacchio A; Mapelli M; Ni J; Scinto L; Stein R; Kosik KS; Yeh LA
    J Biomol Screen; 2004 Mar; 9(2):122-31. PubMed ID: 15006135
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells.
    Shelton SB; Krishnamurthy P; Johnson GV
    J Neurosci Res; 2004 Apr; 76(1):110-20. PubMed ID: 15048935
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants.
    Flaherty DB; Soria JP; Tomasiewicz HG; Wood JG
    J Neurosci Res; 2000 Nov; 62(3):463-72. PubMed ID: 11054815
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract.
    Hosoi T; Uchiyama M; Okumura E; Saito T; Ishiguro K; Uchida T; Okuyama A; Kishimoto T; Hisanaga S
    J Biochem; 1995 Apr; 117(4):741-9. PubMed ID: 7592534
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex.
    Hamdane M; Sambo AV; Delobel P; Bégard S; Violleau A; Delacourte A; Bertrand P; Benavides J; Buée L
    J Biol Chem; 2003 Sep; 278(36):34026-34. PubMed ID: 12826674
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.
    Hoffmann R; Lee VM; Leight S; Varga I; Otvos L
    Biochemistry; 1997 Jul; 36(26):8114-24. PubMed ID: 9201960
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.
    Ahn JS; Radhakrishnan ML; Mapelli M; Choi S; Tidor B; Cuny GD; Musacchio A; Yeh LA; Kosik KS
    Chem Biol; 2005 Jul; 12(7):811-23. PubMed ID: 16039528
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors.
    Liu M; Choi S; Cuny GD; Ding K; Dobson BC; Glicksman MA; Auerbach K; Stein RL
    Biochemistry; 2008 Aug; 47(32):8367-77. PubMed ID: 18636751
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.
    Kerokoski P; Suuronen T; Salminen A; Soininen H; Pirttilä T
    Biochem Biophys Res Commun; 2001 Feb; 280(4):998-1002. PubMed ID: 11162625
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons.
    Zheng YL; Kesavapany S; Gravell M; Hamilton RS; Schubert M; Amin N; Albers W; Grant P; Pant HC
    EMBO J; 2005 Jan; 24(1):209-20. PubMed ID: 15592431
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cdk5 as a drug target for the treatment of Alzheimer's disease.
    Lau LF; Seymour PA; Sanner MA; Schachter JB
    J Mol Neurosci; 2002 Dec; 19(3):267-73. PubMed ID: 12540052
    [TBL] [Abstract][Full Text] [Related]  

  • 12. p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.
    Town T; Zolton J; Shaffner R; Schnell B; Crescentini R; Wu Y; Zeng J; DelleDonne A; Obregon D; Tan J; Mullan M
    J Neurosci Res; 2002 Aug; 69(3):362-72. PubMed ID: 12125077
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles.
    Augustinack JC; Sanders JL; Tsai LH; Hyman BT
    J Neuropathol Exp Neurol; 2002 Jun; 61(6):557-64. PubMed ID: 12071639
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta.
    Li T; Hawkes C; Qureshi HY; Kar S; Paudel HK
    Biochemistry; 2006 Mar; 45(10):3134-45. PubMed ID: 16519508
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.
    Sengupta A; Novak M; Grundke-Iqbal I; Iqbal K
    FEBS Lett; 2006 Oct; 580(25):5925-33. PubMed ID: 17045592
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.
    Jämsä A; Hasslund K; Cowburn RF; Bäckström A; Vasänge M
    Biochem Biophys Res Commun; 2004 Jul; 319(3):993-1000. PubMed ID: 15184080
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.
    Patrick GN; Zukerberg L; Nikolic M; de la Monte S; Dikkes P; Tsai LH
    Nature; 1999 Dec; 402(6762):615-22. PubMed ID: 10604467
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New approaches to the discovery of cdk5 inhibitors.
    Glicksman MA; Cuny GD; Liu M; Dobson B; Auerbach K; Stein RL; Kosik KS
    Curr Alzheimer Res; 2007 Dec; 4(5):547-9. PubMed ID: 18220519
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Kinetic mechanistic studies of Cdk5/p25-catalyzed H1P phosphorylation: metal effect and solvent kinetic isotope effect.
    Liu M; Girma E; Glicksman MA; Stein RL
    Biochemistry; 2010 Jun; 49(23):4921-9. PubMed ID: 20491486
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules.
    Sengupta A; Kabat J; Novak M; Wu Q; Grundke-Iqbal I; Iqbal K
    Arch Biochem Biophys; 1998 Sep; 357(2):299-309. PubMed ID: 9735171
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 3.