BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

314 related articles for article (PubMed ID: 15020590)

  • 1. A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.
    Joyce MG; Girvan HM; Munro AW; Leys D
    J Biol Chem; 2004 May; 279(22):23287-93. PubMed ID: 15020590
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.
    Girvan HM; Marshall KR; Lawson RJ; Leys D; Joyce MG; Clarkson J; Smith WE; Cheesman MR; Munro AW
    J Biol Chem; 2004 May; 279(22):23274-86. PubMed ID: 15020591
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3.
    Girvan HM; Seward HE; Toogood HS; Cheesman MR; Leys D; Munro AW
    J Biol Chem; 2007 Jan; 282(1):564-72. PubMed ID: 17077084
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.
    Noble MA; Girvan HM; Smith SJ; Smith WE; Murataliev M; Guzov VM; Feyereisen R; Munro AW
    Drug Metab Rev; 2007; 39(2-3):599-617. PubMed ID: 17786641
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Oxygen activation and electron transfer in flavocytochrome P450 BM3.
    Ost TW; Clark J; Mowat CG; Miles CS; Walkinshaw MD; Reid GA; Chapman SK; Daff S
    J Am Chem Soc; 2003 Dec; 125(49):15010-20. PubMed ID: 14653735
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel haem co-ordination variants of flavocytochrome P450BM3.
    Girvan HM; Toogood HS; Littleford RE; Seward HE; Smith WE; Ekanem IS; Leys D; Cheesman MR; Munro AW
    Biochem J; 2009 Jan; 417(1):65-76. PubMed ID: 18721129
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency.
    Huang WC; Westlake AC; Maréchal JD; Joyce MG; Moody PC; Roberts GC
    J Mol Biol; 2007 Oct; 373(3):633-51. PubMed ID: 17868686
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phe393 mutants of cytochrome P450 BM3 with modified heme redox potentials have altered heme vinyl and propionate conformations.
    Chen Z; Ost TW; Schelvis JP
    Biochemistry; 2004 Feb; 43(7):1798-808. PubMed ID: 14967021
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 4-cyanopyridine, a versatile spectroscopic probe for cytochrome P450 BM3.
    Ost TW; Clark JP; Anderson JL; Yellowlees LJ; Daff S; Chapman SK
    J Biol Chem; 2004 Nov; 279(47):48876-82. PubMed ID: 15364917
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.
    Gustafsson MC; Roitel O; Marshall KR; Noble MA; Chapman SK; Pessegueiro A; Fulco AJ; Cheesman MR; von Wachenfeldt C; Munro AW
    Biochemistry; 2004 May; 43(18):5474-87. PubMed ID: 15122913
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular dynamics simulations of P450 BM3--examination of substrate-induced conformational change.
    Chang YT; Loew GH
    J Biomol Struct Dyn; 1999 Jun; 16(6):1189-203. PubMed ID: 10447203
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Electron transfer in flavocytochrome P450 BM3: kinetics of flavin reduction and oxidation, the role of cysteine 999, and relationships with mammalian cytochrome P450 reductase.
    Roitel O; Scrutton NS; Munro AW
    Biochemistry; 2003 Sep; 42(36):10809-21. PubMed ID: 12962506
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3.
    Ost TW; Munro AW; Mowat CG; Taylor PR; Pesseguiero A; Fulco AJ; Cho AK; Cheesman MA; Walkinshaw MD; Chapman SK
    Biochemistry; 2001 Nov; 40(45):13430-8. PubMed ID: 11695889
    [TBL] [Abstract][Full Text] [Related]  

  • 14. P450 BM3: the very model of a modern flavocytochrome.
    Munro AW; Leys DG; McLean KJ; Marshall KR; Ost TW; Daff S; Miles CS; Chapman SK; Lysek DA; Moser CC; Page CC; Dutton PL
    Trends Biochem Sci; 2002 May; 27(5):250-7. PubMed ID: 12076537
    [TBL] [Abstract][Full Text] [Related]  

  • 15. NMR studies of substrate binding to cytochrome P450 BM3: comparisons to cytochrome P450 cam.
    Modi S; Primrose WU; Boyle JM; Gibson CF; Lian LY; Roberts GC
    Biochemistry; 1995 Jul; 34(28):8982-8. PubMed ID: 7619797
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.
    Neeli R; Girvan HM; Lawrence A; Warren MJ; Leys D; Scrutton NS; Munro AW
    FEBS Lett; 2005 Oct; 579(25):5582-8. PubMed ID: 16214136
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.
    Girvan HM; Levy CW; Williams P; Fisher K; Cheesman MR; Rigby SE; Leys D; Munro AW
    Biochem J; 2010 Apr; 427(3):455-66. PubMed ID: 20180779
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Conformational dynamics in cytochrome P450-substrate interactions.
    Li H; Poulos TL
    Biochimie; 1996; 78(8-9):695-9. PubMed ID: 9010597
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450 BM3.
    Ost TW; Miles CS; Munro AW; Murdoch J; Reid GA; Chapman SK
    Biochemistry; 2001 Nov; 40(45):13421-9. PubMed ID: 11695888
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3.
    Noble MA; Quaroni L; Chumanov GD; Turner KL; Chapman SK; Hanzlik RP; Munro AW
    Biochemistry; 1998 Nov; 37(45):15799-807. PubMed ID: 9843385
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.