BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 15023348)

  • 1. Design of hypoxia-targeting protein tyrosine kinase inhibitor using an innovative pharmacophore 2-methylene-4-cyclopentene-1,3-dione.
    Hori H; Nagasawa H; Uto Y; Ohkura K; Kirk KL; Uehara Y; Shimamura M
    Biochim Biophys Acta; 2004 Mar; 1697(1-2):29-38. PubMed ID: 15023348
    [TBL] [Abstract][Full Text] [Related]  

  • 2. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.
    Hori H; Nagasawa H; Ishibashi M; Uto Y; Hirata A; Saijo K; Ohkura K; Kirk KL; Uehara Y
    Bioorg Med Chem; 2002 Oct; 10(10):3257-65. PubMed ID: 12150871
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An Antitumor 2-Hydroxyarylidene-4-cyclopentene-1,3-Dione as a Protein Tyrosine Kinase Inhibitor: Interaction Between TX-1123 Derivatives and Src Kinase.
    Ohkura K; Kawaguchi Y; Tatematsu Y; Uto Y; Hori H
    Anticancer Res; 2016 Jul; 36(7):3645-9. PubMed ID: 27354635
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design of antiangiogenic hypoxic cell radiosensitizers: 2-nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety.
    Uto Y; Nagasawa H; Jin CZ; Nakayama S; Tanaka A; Kiyoi S; Nakashima H; Shimamura M; Inayama S; Fujiwara T; Takeuchi Y; Uehara Y; Kirk KL; Nakata E; Hori H
    Bioorg Med Chem; 2008 Jun; 16(11):6042-53. PubMed ID: 18474428
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemosensitization of glioblastoma cells to bis-dichloroethyl-nitrosourea with tyrphostin AG17.
    Liang BC; Ullyatt E
    Clin Cancer Res; 1998 Mar; 4(3):773-81. PubMed ID: 9533547
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs.
    Ohkura K; Tatematsu Y; Kawaguchi Y; Uto Y; Hori H
    Anticancer Res; 2017 Jul; 37(7):3849-3854. PubMed ID: 28668885
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria.
    Burger AM; Kaur G; Alley MC; Supko JG; Malspeis L; Grever MR; Sausville EA
    Cancer Res; 1995 Jul; 55(13):2794-9. PubMed ID: 7796405
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Correlation Between Radiosensitizing Activity and the Stereo-structure of the TX-2036 Series of Molecules.
    Ohkura K; Tabata A; Uto Y; Hori H
    Anticancer Res; 2019 Aug; 39(8):4479-4483. PubMed ID: 31366548
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.
    Tallett A; Chilvers ER; Hannah S; Dransfield I; Lawson MF; Haslett C; Sethi T
    Cancer Res; 1996 Sep; 56(18):4255-63. PubMed ID: 8797601
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor RG13022.
    McLeod HL; Brunton VG; Eckardt N; Lear MJ; Robins DJ; Workman P; Graham MA
    Br J Cancer; 1996 Dec; 74(11):1714-8. PubMed ID: 8956783
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tyrphostin attenuates platelet-derived growth factor-induced contraction in aortic smooth muscle through inhibition of protein tyrosine kinase(s).
    Sauro MD; Thomas B
    J Pharmacol Exp Ther; 1993 Dec; 267(3):1119-25. PubMed ID: 8263773
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Specificity of alpha-cyano-beta-hydroxy-beta-methyl-n-[4-(trifluoromethoxy)phe nyl]-propenamide as an inhibitor of the epidermal growth factor receptor tyrosine kinase.
    Ghosh S; Zheng Y; Jun X; Mahajan S; Mao C; Sudbeck EA; Uckun FM
    Clin Cancer Res; 1999 Dec; 5(12):4264-72. PubMed ID: 10632369
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction.
    Levitzki A
    FASEB J; 1992 Nov; 6(14):3275-82. PubMed ID: 1426765
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A tyrphostin-derived inhibitor of protein tyrosine kinases: isolation and characterization.
    Ramdas L; Obeyesekere NU; McMurray JS; Gallick GE; Seifert WE; Budde RJ
    Arch Biochem Biophys; 1995 Nov; 323(2):237-42. PubMed ID: 7487083
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tyrphostins are inhibitors of guanylyl and adenylyl cyclases.
    Jaleel M; Shenoy AR; Visweswariah SS
    Biochemistry; 2004 Jun; 43(25):8247-55. PubMed ID: 15209521
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of topoisomerase I activity by tyrphostin derivatives, protein tyrosine kinase blockers: mechanism of action.
    Aflalo E; Iftach S; Segal S; Gazit A; Priel E
    Cancer Res; 1994 Oct; 54(19):5138-42. PubMed ID: 7923131
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents.
    Wells G; Seaton A; Stevens MF
    J Med Chem; 2000 Apr; 43(8):1550-62. PubMed ID: 10780912
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tyrosine kinases as targets for cancer therapy.
    Levitzki A
    Eur J Cancer; 2002 Sep; 38 Suppl 5():S11-8. PubMed ID: 12528768
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of protein tyrosine kinase inhibitors on voltage-operated calcium channel currents in vascular smooth muscle cells and pp60(c-src) kinase activity.
    Wijetunge S; Lymn JS; Hughes AD
    Br J Pharmacol; 2000 Apr; 129(7):1347-54. PubMed ID: 10742290
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and synthesis of novel tyrosine kinase inhibitors using a pharmacophore model of the ATP-binding site of the EGF-R.
    Traxler P; Furet P; Mett H; Buchdunger E; Meyer T; Lydon N
    J Pharm Belg; 1997; 52(2):88-96. PubMed ID: 9193132
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.