BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

271 related articles for article (PubMed ID: 15023365)

  • 21. Systematic comparison of competitive and allosteric kinase inhibitors reveals common structural characteristics.
    Hu H; Laufkötter O; Miljković F; Bajorath J
    Eur J Med Chem; 2021 Mar; 214():113206. PubMed ID: 33540355
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Comprehensive analysis of three-dimensional activity cliffs formed by kinase inhibitors with different binding modes and cliff mapping of structural analogues.
    Furtmann N; Hu Y; Bajorath J
    J Med Chem; 2015 Jan; 58(1):252-64. PubMed ID: 25054653
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Kinase-kernel models: accurate in silico screening of 4 million compounds across the entire human kinome.
    Martin E; Mukherjee P
    J Chem Inf Model; 2012 Jan; 52(1):156-70. PubMed ID: 22133092
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Advancing the kinase field: new targets and second generation inhibitors.
    Laufer S; Bajorath J
    J Med Chem; 2015 Jan; 58(1):1. PubMed ID: 25490234
    [No Abstract]   [Full Text] [Related]  

  • 25. The structure-based design of ATP-site directed protein kinase inhibitors.
    Toledo LM; Lydon NB; Elbaum D
    Curr Med Chem; 1999 Sep; 6(9):775-805. PubMed ID: 10495352
    [TBL] [Abstract][Full Text] [Related]  

  • 26. A chemogenomics view on protein-ligand spaces.
    Strömbergsson H; Kleywegt GJ
    BMC Bioinformatics; 2009 Jun; 10 Suppl 6(Suppl 6):S13. PubMed ID: 19534738
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases.
    Graczyk PP
    J Med Chem; 2007 Nov; 50(23):5773-9. PubMed ID: 17948979
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Interaction profiles of protein kinase-inhibitor complexes and their application to virtual screening.
    Chuaqui C; Deng Z; Singh J
    J Med Chem; 2005 Jan; 48(1):121-33. PubMed ID: 15634006
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Cyclin-dependent kinase inhibitors.
    Fischer PM; Endicott J; Meijer L
    Prog Cell Cycle Res; 2003; 5():235-48. PubMed ID: 14593718
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Chemogenomics knowledge-based strategies in drug discovery.
    Jacoby E; Schuffenhauer A; Floersheim P
    Drug News Perspect; 2003 Mar; 16(2):93-102. PubMed ID: 12792670
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Identification of novel BRAF kinase inhibitors with structure-based virtual screening.
    Park H; Choi H; Hong S; Hong S
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5753-6. PubMed ID: 21873050
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Computational analysis of activity and selectivity cliffs.
    Peltason L; Bajorath J
    Methods Mol Biol; 2011; 672():119-32. PubMed ID: 20838966
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Proteochemometric recognition of stable kinase inhibition complexes using topological autocorrelation and support vector machines.
    Fernandez M; Ahmad S; Sarai A
    J Chem Inf Model; 2010 Jun; 50(6):1179-88. PubMed ID: 20524632
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Kinase chemogenomics: targeting the human kinome for target validation and drug discovery.
    ter Haar E; Walters WP; Pazhanisamy S; Taslimi P; Pierce AC; Bemis GW; Salituro FG; Harbeson SL
    Mini Rev Med Chem; 2004 Mar; 4(3):235-53. PubMed ID: 15032672
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Computational proteomics of biomolecular interactions in the sequence and structure space of the tyrosine kinome: deciphering the molecular basis of the kinase inhibitors selectivity.
    Verkhivker GM
    Proteins; 2007 Mar; 66(4):912-29. PubMed ID: 17173284
    [TBL] [Abstract][Full Text] [Related]  

  • 36. High-throughput biochemical kinase selectivity assays: panel development and screening applications.
    Card A; Caldwell C; Min H; Lokchander B; Hualin Xi ; Sciabola S; Kamath AV; Clugston SL; Tschantz WR; Leyu Wang ; Moshinsky DJ
    J Biomol Screen; 2009 Jan; 14(1):31-42. PubMed ID: 19073965
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Chemical fragments as foundations for understanding target space and activity prediction.
    Sutherland JJ; Higgs RE; Watson I; Vieth M
    J Med Chem; 2008 May; 51(9):2689-700. PubMed ID: 18386916
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Design and synthesis of novel tyrosine kinase inhibitors using a pharmacophore model of the ATP-binding site of the EGF-R.
    Traxler P; Furet P; Mett H; Buchdunger E; Meyer T; Lydon N
    J Pharm Belg; 1997; 52(2):88-96. PubMed ID: 9193132
    [TBL] [Abstract][Full Text] [Related]  

  • 39. A quantitative analysis of kinase inhibitor selectivity.
    Karaman MW; Herrgard S; Treiber DK; Gallant P; Atteridge CE; Campbell BT; Chan KW; Ciceri P; Davis MI; Edeen PT; Faraoni R; Floyd M; Hunt JP; Lockhart DJ; Milanov ZV; Morrison MJ; Pallares G; Patel HK; Pritchard S; Wodicka LM; Zarrinkar PP
    Nat Biotechnol; 2008 Jan; 26(1):127-32. PubMed ID: 18183025
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases.
    Cox KJ; Shomin CD; Ghosh I
    Future Med Chem; 2011 Jan; 3(1):29-43. PubMed ID: 21428824
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 14.