BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

535 related articles for article (PubMed ID: 15025514)

  • 1. The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.
    Mijal RS; Thomson NM; Fleischer NL; Pauly GT; Moschel RC; Kanugula S; Fang Q; Pegg AE; Peterson LA
    Chem Res Toxicol; 2004 Mar; 17(3):424-34. PubMed ID: 15025514
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice.
    Thomson NM; Kenney PM; Peterson LA
    Chem Res Toxicol; 2003 Jan; 16(1):1-6. PubMed ID: 12693024
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase.
    Wang L; Spratt TE; Pegg AE; Peterson LA
    Chem Res Toxicol; 1999 Feb; 12(2):127-31. PubMed ID: 10027788
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases.
    Mijal RS; Kanugula S; Vu CC; Fang Q; Pegg AE; Peterson LA
    Cancer Res; 2006 May; 66(9):4968-74. PubMed ID: 16651455
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.
    Wang L; Spratt TE; Liu XK; Hecht SS; Pegg AE; Peterson LA
    Chem Res Toxicol; 1997 May; 10(5):562-7. PubMed ID: 9168254
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase.
    Kotandeniya D; Murphy D; Yan S; Park S; Seneviratne U; Koopmeiners JS; Pegg A; Kanugula S; Kassie F; Tretyakova N
    Biochemistry; 2013 Jun; 52(23):4075-88. PubMed ID: 23683164
    [TBL] [Abstract][Full Text] [Related]  

  • 7. O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents.
    Mijal RS; Loktionova NA; Vu CC; Pegg AE; Peterson LA
    Chem Res Toxicol; 2005 Oct; 18(10):1619-25. PubMed ID: 16533027
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.
    Peterson LA; Liu XK; Hecht SS
    Cancer Res; 1993 Jun; 53(12):2780-5. PubMed ID: 8504419
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA.
    Kotandeniya D; Murphy D; Seneviratne U; Guza R; Pegg A; Kanugula S; Tretyakova N
    Chem Res Toxicol; 2011 Nov; 24(11):1966-75. PubMed ID: 21913712
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase.
    Liu XK; Spratt TE; Murphy SE; Peterson LA
    Chem Res Toxicol; 1996 Sep; 9(6):949-53. PubMed ID: 8870981
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice.
    Urban AM; Upadhyaya P; Cao Q; Peterson LA
    Chem Res Toxicol; 2012 Oct; 25(10):2167-78. PubMed ID: 22928598
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine.
    Thomson NM; Mijal RS; Ziegel R; Fleischer NL; Pegg AE; Tretyakova NY; Peterson LA
    Chem Res Toxicol; 2004 Dec; 17(12):1600-6. PubMed ID: 15606135
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.
    Xu-Welliver M; Leitão J; Kanugula S; Pegg AE
    Cancer Res; 1999 Apr; 59(7):1514-9. PubMed ID: 10197622
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
    Loktionova NA; Xu-Welliver M; Crone TM; Kanugula S; Pegg AE
    Biochem Pharmacol; 1999 Jul; 58(2):237-44. PubMed ID: 10423163
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Ziegel R; Shallop A; Upadhyaya P; Jones R; Tretyakova N
    Biochemistry; 2004 Jan; 43(2):540-9. PubMed ID: 14717610
    [TBL] [Abstract][Full Text] [Related]  

  • 16. K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts.
    Ziegel R; Shallop A; Jones R; Tretyakova N
    Chem Res Toxicol; 2003 Apr; 16(4):541-50. PubMed ID: 12703972
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.
    Pegg AE; Scicchitano D; Dolan ME
    Cancer Res; 1984 Sep; 44(9):3806-11. PubMed ID: 6378375
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel, sensitive assay for O6-methyl- and O6-ethylguanine in DNA, based on repair by the enzyme O6-alkylguanine-DNA-alkyltransferase in competition with an oligonucleotide containing O6-methylguanine.
    Souliotis VL; Kyrtopoulos SA
    Cancer Res; 1989 Dec; 49(24 Pt 1):6997-7001. PubMed ID: 2684406
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase.
    Goodtzova K; Kanugula S; Edara S; Pegg AE
    Biochemistry; 1998 Sep; 37(36):12489-95. PubMed ID: 9730821
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides.
    Pegg AE; Kanugula S; Edara S; Pauly GT; Moschel RC; Goodtzova K
    J Biol Chem; 1998 May; 273(18):10863-7. PubMed ID: 9556560
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.