104 related articles for article (PubMed ID: 15026043)
1. Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists.
Huryn DM; Ashwell S; Baudy R; Dressen DB; Gallaway W; Grant FS; Konradi A; Ley RW; Petusky S; Pleiss MA; Sarantakis D; Semko CM; Sherman MM; Tio C; Zhang L
Bioorg Med Chem Lett; 2004 Apr; 14(7):1651-4. PubMed ID: 15026043
[TBL] [Abstract][Full Text] [Related]
2. Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Venkatraman S; Lebsack AD; Alves K; Gardner MF; James J; Lingham RB; Maniar S; Mumford RA; Si Q; Stock N; Treonze KM; Wang B; Zunic J; Munoz B
Bioorg Med Chem Lett; 2009 Oct; 19(19):5803-6. PubMed ID: 19713111
[TBL] [Abstract][Full Text] [Related]
3. Critical period for a teratogenic VLA-4 antagonist: Developmental effects and comparison of embryo drug concentrations of teratogenic and non-teratogenic VLA-4 antagonists.
Crofts F; Rohatagi S; Pino M; DeLise B; Zhang J; Nguyen M; Guittin P; Barbellion S; Brunel P; Hofmann T; Schmidt J; Wong M; Lockey P; Lerman S; Clark R
Birth Defects Res B Dev Reprod Toxicol; 2004 Apr; 71(2):69-79. PubMed ID: 15098200
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.
Gong Y; Barbay JK; Dyatkin AB; Miskowski TA; Kimball ES; Prouty SM; Fisher MC; Santulli RJ; Schneider CR; Wallace NH; Ballentine SA; Hageman WE; Masucci JA; Maryanoff BE; Damiano BP; Andrade-Gordon P; Hlasta DJ; Hornby PJ; He W
J Med Chem; 2006 Jun; 49(11):3402-11. PubMed ID: 16722660
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of pro-drugs of GW196771, a potent glycine antagonist acting at the NMDA receptor.
Angusti A; Durini E; Vertuani S; Dalpiaz A; Ruffo A; Di Fabio R; Donati D; Pentassuglia G; Vitulli G; Barnaby RJ; Manfredini S
Farmaco; 2005 May; 60(5):393-7. PubMed ID: 15885689
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.
Chiba J; Iimura S; Yoneda Y; Watanabe T; Muro F; Tsubokawa M; Iigou Y; Satoh A; Takayama G; Yokoyama M; Takashi T; Nakayama A; Machinaga N
Bioorg Med Chem; 2007 Feb; 15(4):1679-93. PubMed ID: 17194595
[TBL] [Abstract][Full Text] [Related]
7. Different embryo-fetal toxicity effects for three VLA-4 antagonists.
Crofts F; Pino M; DeLise B; Guittin P; Barbellion S; Brunel P; Potdevin S; Bergmann B; Hofmann T; Lerman S; Clark RL
Birth Defects Res B Dev Reprod Toxicol; 2004 Apr; 71(2):55-68. PubMed ID: 15098199
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
Chiba J; Takayama G; Takashi T; Yokoyama M; Nakayama A; Baldwin JJ; McDonald E; Moriarty KJ; Sarko CR; Saionz KW; Swanson R; Hussain Z; Wong A; Machinaga N
Bioorg Med Chem; 2006 Apr; 14(8):2725-46. PubMed ID: 16377201
[TBL] [Abstract][Full Text] [Related]
9. Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.
Reger TS; Zunic J; Stock N; Wang B; Smith ND; Munoz B; Green MD; Gardner MF; James JP; Chen W; Alves K; Si Q; Treonze KM; Lingham RB; Mumford RA
Bioorg Med Chem Lett; 2010 Feb; 20(3):1173-6. PubMed ID: 20022493
[TBL] [Abstract][Full Text] [Related]
10. Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.
Witherington J; Blaney EL; Bordas V; Elliott RL; Gaiba A; Garton N; Green PM; Naylor A; Smith DG; Spalding DJ; Takle AK; Ward RW
Bioorg Med Chem Lett; 2006 Nov; 16(21):5538-41. PubMed ID: 16931004
[TBL] [Abstract][Full Text] [Related]
11. A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.
Muro F; Iimura S; Yoneda Y; Chiba J; Watanabe T; Setoguchi M; Takayama G; Yokoyama M; Takashi T; Nakayama A; Machinaga N
Bioorg Med Chem; 2009 Feb; 17(3):1232-43. PubMed ID: 19124247
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and biological activity of N-substituted aminocarbonyl-1,3-dioxolanes as VLA-4 antagonists.
Rehman A; Soni A; Naik K; Nair S; Palle VP; Dastidar S; Ray A; Alam MS; Salman M; Cliffe IA; Sattigeri V
Bioorg Med Chem Lett; 2010 Sep; 20(18):5514-20. PubMed ID: 20705461
[TBL] [Abstract][Full Text] [Related]
13. Identification of N-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual acting α4β1 and α4β7 receptor antagonists.
Tilley JW; Sidduri A; Lou J; Kaplan G; Tare N; Cavallo G; Frank K; Pamidimukkala A; Choi DS; Gerber L; Railkar A; Renzetti L
Bioorg Med Chem Lett; 2013 Feb; 23(4):1036-40. PubMed ID: 23312471
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4.
Okigami H; Takeshita K; Tajimi M; Komura H; Albers M; Lehmann TE; Rölle T; Bacon KB
Eur J Pharmacol; 2007 Mar; 559(2-3):202-9. PubMed ID: 17234179
[TBL] [Abstract][Full Text] [Related]
15. The identification and optimization of orally efficacious, small molecule VLA-4 antagonists.
Huryn DM; Konradi AW; Ashwell S; Freedman SB; Lombardo LJ; Pleiss MA; Thorsett ED; Yednock T; Kennedy JD
Curr Top Med Chem; 2004; 4(14):1473-84. PubMed ID: 15544538
[TBL] [Abstract][Full Text] [Related]
16. Influence of acid surrogates toward potency of VLA-4 antagonist.
Venkatraman S; Lim J; Cramer M; Gardner MF; James J; Alves K; Lingham RB; Mumford RA; Munoz B
Bioorg Med Chem Lett; 2005 Sep; 15(18):4053-6. PubMed ID: 16039122
[TBL] [Abstract][Full Text] [Related]
17. Imidazopyridines as VLA-4 integrin antagonists.
Phillips DJ; Davenport RJ; Demaude TA; Galleway FP; Jones MW; Knerr L; Perry BG; Ratcliffe AJ
Bioorg Med Chem Lett; 2008 Jul; 18(14):4146-9. PubMed ID: 18539454
[TBL] [Abstract][Full Text] [Related]
18. Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists.
Dyatkin AB; Gong Y; Miskowski TA; Kimball ES; Prouty SM; Fisher MC; Santulli RJ; Schneider CR; Wallace NH; Hornby PJ; Diamond C; Kinney WA; Maryanoff BE; Damiano BP; He W
Bioorg Med Chem; 2005 Dec; 13(24):6693-702. PubMed ID: 16112583
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.
Nakamura A; Yamada T; Asaki T
Bioorg Med Chem; 2007 Dec; 15(24):7720-5. PubMed ID: 17881233
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and in vitro studies on a potential dopamine prodrug.
Giannola LI; De Caro V; Giandalia G; Siragusa MG; Lamartina L
Pharmazie; 2008 Oct; 63(10):704-10. PubMed ID: 18972830
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
