BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 15028732)

  • 1. Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.
    Suzuki R; Tobe K; Aoyama M; Inoue A; Sakamoto K; Yamauchi T; Kamon J; Kubota N; Terauchi Y; Yoshimatsu H; Matsuhisa M; Nagasaka S; Ogata H; Tokuyama K; Nagai R; Kadowaki T
    J Biol Chem; 2004 Jun; 279(24):25039-49. PubMed ID: 15028732
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
    Kubota N; Tobe K; Terauchi Y; Eto K; Yamauchi T; Suzuki R; Tsubamoto Y; Komeda K; Nakano R; Miki H; Satoh S; Sekihara H; Sciacchitano S; Lesniak M; Aizawa S; Nagai R; Kimura S; Akanuma Y; Taylor SI; Kadowaki T
    Diabetes; 2000 Nov; 49(11):1880-9. PubMed ID: 11078455
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
    Kubota N; Terauchi Y; Tobe K; Yano W; Suzuki R; Ueki K; Takamoto I; Satoh H; Maki T; Kubota T; Moroi M; Okada-Iwabu M; Ezaki O; Nagai R; Ueta Y; Kadowaki T; Noda T
    J Clin Invest; 2004 Oct; 114(7):917-27. PubMed ID: 15467830
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2.
    Hashimoto H; Arai T; Takeguchi A; Hioki K; Ohnishi Y; Kawai K; Ito M; Suzuki R; Yamauchi T; Ohsugi M; Saito M; Ueyama Y; Tobe K; Kadowaki T; Tamaoki N; Kosaka K
    Comp Med; 2006 Jun; 56(3):176-87. PubMed ID: 16774126
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis.
    Kushner JA; Simpson L; Wartschow LM; Guo S; Rankin MM; Parsons R; White MF
    J Biol Chem; 2005 Nov; 280(47):39388-93. PubMed ID: 16170201
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disruption of IRS-2 causes type 2 diabetes in mice.
    Withers DJ; Gutierrez JS; Towery H; Burks DJ; Ren JM; Previs S; Zhang Y; Bernal D; Pons S; Shulman GI; Bonner-Weir S; White MF
    Nature; 1998 Feb; 391(6670):900-4. PubMed ID: 9495343
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
    Terauchi Y; Takamoto I; Kubota N; Matsui J; Suzuki R; Komeda K; Hara A; Toyoda Y; Miwa I; Aizawa S; Tsutsumi S; Tsubamoto Y; Hashimoto S; Eto K; Nakamura A; Noda M; Tobe K; Aburatani H; Nagai R; Kadowaki T
    J Clin Invest; 2007 Jan; 117(1):246-57. PubMed ID: 17200721
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet.
    Aoki K; Tajima K; Taguri M; Terauchi Y
    J Steroid Biochem Mol Biol; 2016 May; 159():110-20. PubMed ID: 26976654
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.
    Hashimoto S; Maoka T; Kawata T; Mochizuki T; Koike T; Shigematsu T
    PLoS One; 2020; 15(12):e0242332. PubMed ID: 33270683
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy.
    Ueki K; Yamauchi T; Tamemoto H; Tobe K; Yamamoto-Honda R; Kaburagi Y; Akanuma Y; Yazaki Y; Aizawa S; Nagai R; Kadowaki T
    J Clin Invest; 2000 May; 105(10):1437-45. PubMed ID: 10811851
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.
    Taniguchi CM; Ueki K; Kahn R
    J Clin Invest; 2005 Mar; 115(3):718-27. PubMed ID: 15711641
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.
    Hennige AM; Stefan N; Kapp K; Lehmann R; Weigert C; Beck A; Moeschel K; Mushack J; Schleicher E; Häring HU
    FASEB J; 2006 Jun; 20(8):1206-8. PubMed ID: 16611834
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
    Kushner JA; Haj FG; Klaman LD; Dow MA; Kahn BB; Neel BG; White MF
    Diabetes; 2004 Jan; 53(1):61-6. PubMed ID: 14693698
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.
    Simmgen M; Knauf C; Lopez M; Choudhury AI; Charalambous M; Cantley J; Bedford DC; Claret M; Iglesias MA; Heffron H; Cani PD; Vidal-Puig A; Burcelin R; Withers DJ
    Diabetologia; 2006 Mar; 49(3):552-61. PubMed ID: 16404553
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice.
    Gonzalez-Navarro H; Vila-Caballer M; Pastor MF; Vinue A; White MF; Burks D; Andres V
    Front Biosci; 2007 Jan; 12():2291-8. PubMed ID: 17127239
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice.
    Li J; Houseknecht KL; Stenbit AE; Katz EB; Charron MJ
    FASEB J; 2000 Jun; 14(9):1117-25. PubMed ID: 10834933
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
    Tobe K; Suzuki R; Aoyama M; Yamauchi T; Kamon J; Kubota N; Terauchi Y; Matsui J; Akanuma Y; Kimura S; Tanaka J; Abe M; Ohsumi J; Nagai R; Kadowaki T
    J Biol Chem; 2001 Oct; 276(42):38337-40. PubMed ID: 11546755
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tungstate promotes β-cell survival in Irs2-/- mice.
    Oliveira JM; Rebuffat SA; Gasa R; Burks DJ; Garcia A; Kalko SG; Zafra D; Guinovart JJ; Gomis R
    Am J Physiol Endocrinol Metab; 2014 Jan; 306(1):E36-47. PubMed ID: 24253047
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.
    Zheng Y; Yamada H; Sakamoto K; Horita S; Kunimi M; Endo Y; Li Y; Tobe K; Terauchi Y; Kadowaki T; Seki G; Fujita T
    J Am Soc Nephrol; 2005 Aug; 16(8):2288-95. PubMed ID: 15975995
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.
    Park E; Wong V; Guan X; Oprescu AI; Giacca A
    J Endocrinol; 2007 Nov; 195(2):323-31. PubMed ID: 17951543
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.