329 related articles for article (PubMed ID: 15035625)
1. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; Wilson CA; Lee VM; Doms RW
Biochemistry; 2004 Mar; 43(12):3555-63. PubMed ID: 15035625
[TBL] [Abstract][Full Text] [Related]
2. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
3. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
4. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
5. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Prokop S; Haass C; Steiner H
J Neurochem; 2005 Jul; 94(1):57-62. PubMed ID: 15953349
[TBL] [Abstract][Full Text] [Related]
6. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Fraering PC; LaVoie MJ; Ye W; Ostaszewski BL; Kimberly WT; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Jan; 43(2):323-33. PubMed ID: 14717586
[TBL] [Abstract][Full Text] [Related]
7. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
8. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
9. Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.
Marambaud P; Alves da Costa C; Ancolio K; Checler F
Biochem Biophys Res Commun; 1998 Nov; 252(1):134-8. PubMed ID: 9813158
[TBL] [Abstract][Full Text] [Related]
10. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
11. Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.
Li G; Percontino L; Sun Q; Qazi AS; Frederikse PH
Mol Vis; 2003 May; 9():179-83. PubMed ID: 12740567
[TBL] [Abstract][Full Text] [Related]
12. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
Brunkan AL; Martinez M; Wang J; Walker ES; Beher D; Shearman MS; Goate AM
J Neurochem; 2005 Sep; 94(5):1315-28. PubMed ID: 16001967
[TBL] [Abstract][Full Text] [Related]
13. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
[TBL] [Abstract][Full Text] [Related]
14. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; Serneels L; Saftig P; Craessaerts K; De Strooper B; Hartmann D
Hum Mol Genet; 2004 Jul; 13(13):1321-31. PubMed ID: 15128703
[TBL] [Abstract][Full Text] [Related]
15. PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity.
Aoyagi N; Uemura K; Kuzuya A; Kihara T; Kawamata J; Shimohama S; Kinoshita A; Takahashi R
Biochem Biophys Res Commun; 2010 Jan; 391(2):1240-5. PubMed ID: 20006583
[TBL] [Abstract][Full Text] [Related]
16. Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin.
Bergman A; Hansson EM; Pursglove SE; Farmery MR; Lannfelt L; Lendahl U; Lundkvist J; Näslund J
J Biol Chem; 2004 Apr; 279(16):16744-53. PubMed ID: 14724271
[TBL] [Abstract][Full Text] [Related]
17. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
Shiraishi H; Marutani T; Wang HQ; Maeda Y; Kurono Y; Takashima A; Araki W; Nishimura M; Yanagisawa K; Komano H
Genes Cells; 2006 Jan; 11(1):83-93. PubMed ID: 16371134
[TBL] [Abstract][Full Text] [Related]
18. The role of presenilin cofactors in the gamma-secretase complex.
Takasugi N; Tomita T; Hayashi I; Tsuruoka M; Niimura M; Takahashi Y; Thinakaran G; Iwatsubo T
Nature; 2003 Mar; 422(6930):438-41. PubMed ID: 12660785
[TBL] [Abstract][Full Text] [Related]
19. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
Edbauer D; Winkler E; Haass C; Steiner H
Proc Natl Acad Sci U S A; 2002 Jun; 99(13):8666-71. PubMed ID: 12048259
[TBL] [Abstract][Full Text] [Related]
20. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
Siman R; Salidas S
Neuroscience; 2004; 129(3):615-28. PubMed ID: 15541883
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]