These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

346 related articles for article (PubMed ID: 15047908)

  • 1. Ala226 to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease.
    Jelinek B; Antal J; Venekei I; Gráf L
    Protein Eng Des Sel; 2004 Feb; 17(2):127-31. PubMed ID: 15047908
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The crystal structure of a trypsin-like mutant chymotrypsin: the role of position 226 in the activity and specificity of S189D chymotrypsin.
    Jelinek B; Katona G; Fodor K; Venekei I; Gráf L
    Protein J; 2008 Feb; 27(2):79-87. PubMed ID: 17805946
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Three dimensional structures of S189D chymotrypsin and D189S trypsin mutants: the effect of polarity at site 189 on a protease-specific stabilization of the substrate-binding site.
    Szabó E; Venekei I; Böcskei Z; Náray-Szabó G; Gráf L
    J Mol Biol; 2003 Aug; 331(5):1121-30. PubMed ID: 12927546
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Attempts to convert chymotrypsin to trypsin.
    Venekei I; Szilágyi L; Gráf L; Rutter WJ
    FEBS Lett; 1996 Mar; 383(1-2):143-7. PubMed ID: 8612781
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
    Sprang SR; Fletterick RJ; Gráf L; Rutter WJ; Craik CS
    Crit Rev Biotechnol; 1988; 8(3):225-36. PubMed ID: 3063392
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Attempts to convert chymotrypsin to trypsin.
    Venekei I; Szilágyi L; Gráf L; Rutter WJ
    FEBS Lett; 1996 Jan; 379(2):143-7. PubMed ID: 8635580
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Converting trypsin to elastase: substitution of the S1 site and adjacent loops reconstitutes esterase specificity but not amidase activity.
    Hung SH; Hedstrom L
    Protein Eng; 1998 Aug; 11(8):669-73. PubMed ID: 9749919
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles.
    Schellenberger V; Turck CW; Hedstrom L; Rutter WJ
    Biochemistry; 1993 Apr; 32(16):4349-53. PubMed ID: 8476865
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Trypsin: a case study in the structural determinants of enzyme specificity.
    Hedstrom L
    Biol Chem; 1996; 377(7-8):465-70. PubMed ID: 8922280
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
    Szabó A; Ludwig M; Hegyi E; Szépeová R; Witt H; Sahin-Tóth M
    J Biol Chem; 2015 Jul; 290(28):17282-92. PubMed ID: 26013824
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Probes of the mechanism of zymogen catalysis.
    Lonsdale-Eccles JD; Neurath H; Walsh KA
    Biochemistry; 1978 Jul; 17(14):2805-9. PubMed ID: 687564
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms.
    Kaslik G; Westler WM; Gráf L; Markley JL
    Arch Biochem Biophys; 1999 Feb; 362(2):254-64. PubMed ID: 9989934
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities.
    Pletnev VZ; Zamolodchikova TS; Pangborn WA; Duax WL
    Proteins; 2000 Oct; 41(1):8-16. PubMed ID: 10944388
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cloning and characterization of chymotrypsin- and trypsin-like cDNAs from the gut of the Hessian fly [Mayetiola destructor (Say)].
    Zhu YC; Liu X; Maddur AA; Oppert B; Chen MS
    Insect Biochem Mol Biol; 2005 Jan; 35(1):23-32. PubMed ID: 15607652
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The role of disulfide bond C191-C220 in trypsin and chymotrypsin.
    Várallyay E; Lengyel Z; Gráf L; Szilágyi L
    Biochem Biophys Res Commun; 1997 Jan; 230(3):592-6. PubMed ID: 9015368
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin.
    Castro MJ; Anderson S
    Biochemistry; 1996 Sep; 35(35):11435-46. PubMed ID: 8784199
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Converting trypsin to chymotrypsin: structural determinants of S1' specificity.
    Kurth T; Ullmann D; Jakubke HD; Hedstrom L
    Biochemistry; 1997 Aug; 36(33):10098-104. PubMed ID: 9254605
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Electrostatic complementarity within the substrate-binding pocket of trypsin.
    Gráf L; Jancsó A; Szilágyi L; Hegyi G; Pintér K; Náray-Szabó G; Hepp J; Medzihradszky K; Rutter WJ
    Proc Natl Acad Sci U S A; 1988 Jul; 85(14):4961-5. PubMed ID: 3134655
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant.
    Hedstrom L; Perona JJ; Rutter WJ
    Biochemistry; 1994 Jul; 33(29):8757-63. PubMed ID: 8038165
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity.
    Mace JE; Wilk BJ; Agard DA
    J Mol Biol; 1995 Aug; 251(1):116-34. PubMed ID: 7643381
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.