115 related articles for article (PubMed ID: 15050631)
1. Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.
Esler WP; Das C; Wolfe MS
Bioorg Med Chem Lett; 2004 Apr; 14(8):1935-8. PubMed ID: 15050631
[TBL] [Abstract][Full Text] [Related]
2. Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.
Bakshi P; Wolfe MS
J Med Chem; 2004 Dec; 47(26):6485-9. PubMed ID: 15588083
[TBL] [Abstract][Full Text] [Related]
3. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
Machauer R; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Neumann U; Paganetti P
Bioorg Med Chem Lett; 2009 Mar; 19(5):1361-5. PubMed ID: 19195886
[TBL] [Abstract][Full Text] [Related]
4. Molecular docking and 3D-QSAR studies on the binding mechanism of statine-based peptidomimetics with beta-secretase.
Zuo Z; Luo X; Zhu W; Shen J; Shen X; Jiang H; Chen K
Bioorg Med Chem; 2005 Mar; 13(6):2121-31. PubMed ID: 15727865
[TBL] [Abstract][Full Text] [Related]
5. Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.
Liao YF; Wang BJ; Hsu WM; Lee H; Liao CY; Wu SY; Cheng HT; Hu MK
Mol Pharmacol; 2007 Feb; 71(2):588-601. PubMed ID: 17105873
[TBL] [Abstract][Full Text] [Related]
6. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
Yang W; Lu W; Lu Y; Zhong M; Sun J; Thomas AE; Wilkinson JM; Fucini RV; Lam M; Randal M; Shi XP; Jacobs JW; McDowell RS; Gordon EM; Ballinger MD
J Med Chem; 2006 Feb; 49(3):839-42. PubMed ID: 16451048
[TBL] [Abstract][Full Text] [Related]
7. Hydroxytriamides as potent gamma-secretase inhibitors.
Prasad CV; Wallace OB; Noonan JW; Sloan CP; Lau W; Vig S; Parker MF; Smith DW; Hansel SB; Polson CT; Barten DM; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2004 Apr; 14(8):1917-21. PubMed ID: 15050627
[TBL] [Abstract][Full Text] [Related]
8. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
Knappenberger KS; Tian G; Ye X; Sobotka-Briner C; Ghanekar SV; Greenberg BD; Scott CW
Biochemistry; 2004 May; 43(20):6208-18. PubMed ID: 15147205
[TBL] [Abstract][Full Text] [Related]
9. 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
Shaw D; Best J; Dinnell K; Nadin A; Shearman M; Pattison C; Peachey J; Reilly M; Williams B; Wrigley J; Harrison T
Bioorg Med Chem Lett; 2006 Jun; 16(11):3073-7. PubMed ID: 16617016
[TBL] [Abstract][Full Text] [Related]
10. Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.
Moore CL; Leatherwood DD; Diehl TS; Selkoe DJ; Wolfe MS
J Med Chem; 2000 Sep; 43(18):3434-42. PubMed ID: 10978191
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
Ghosh AK; Kumaragurubaran N; Hong L; Kulkarni SS; Xu X; Chang W; Weerasena V; Turner R; Koelsch G; Bilcer G; Tang J
J Med Chem; 2007 May; 50(10):2399-407. PubMed ID: 17432843
[TBL] [Abstract][Full Text] [Related]
12. Designed helical peptides inhibit an intramembrane protease.
Das C; Berezovska O; Diehl TS; Genet C; Buldyrev I; Tsai JY; Hyman BT; Wolfe MS
J Am Chem Soc; 2003 Oct; 125(39):11794-5. PubMed ID: 14505382
[TBL] [Abstract][Full Text] [Related]
13. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
[TBL] [Abstract][Full Text] [Related]
14. Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors.
Gundersen E; Fan K; Haas K; Huryn D; Steven Jacobsen J; Kreft A; Martone R; Mayer S; Sonnenberg-Reines J; Sun SC; Zhou H
Bioorg Med Chem Lett; 2005 Apr; 15(7):1891-4. PubMed ID: 15780628
[TBL] [Abstract][Full Text] [Related]
15. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Wrigley JD; Nunn EJ; Nyabi O; Clarke EE; Hunt P; Nadin A; De Strooper B; Shearman MS; Beher D
J Neurochem; 2004 Sep; 90(6):1312-20. PubMed ID: 15341515
[TBL] [Abstract][Full Text] [Related]
16. Conformationally biased P3 amide replacements of beta-secretase inhibitors.
Stachel SJ; Coburn CA; Steele TG; Crouthamel MC; Pietrak BL; Lai MT; Holloway MK; Munshi SK; Graham SL; Vacca JP
Bioorg Med Chem Lett; 2006 Feb; 16(3):641-4. PubMed ID: 16263281
[TBL] [Abstract][Full Text] [Related]
17. Conformational flexibility of beta-secretase: molecular dynamics simulation and essential dynamics analysis.
Xiong B; Huang XQ; Shen LL; Shen JH; Luo XM; Shen X; Jiang HL; Chen KX
Acta Pharmacol Sin; 2004 Jun; 25(6):705-13. PubMed ID: 15169620
[TBL] [Abstract][Full Text] [Related]
18. Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.
Kan T; Tominari Y; Rikimaru K; Morohashi Y; Natsugari H; Tomita T; Iwatsubo T; Fukuyama T
Bioorg Med Chem Lett; 2004 Apr; 14(8):1983-5. PubMed ID: 15050642
[TBL] [Abstract][Full Text] [Related]
19. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
Machauer R; Laumen K; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Jaton AL; Desrayaud S; Staufenbiel M; Rabe S; Paganetti P; Neumann U
Bioorg Med Chem Lett; 2009 Mar; 19(5):1366-70. PubMed ID: 19195887
[TBL] [Abstract][Full Text] [Related]
20. Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Bihel F; Das C; Bowman MJ; Wolfe MS
J Med Chem; 2004 Jul; 47(16):3931-3. PubMed ID: 15267231
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
