BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

139 related articles for article (PubMed ID: 15055991)

  • 21. Quantitative structure-activity relationship study of new potent and selective antagonists at the 5-HT(1A) and adrenergic alpha(1d) receptors: Derivatives of spiroethyl phenyl(substituted)piperazine.
    Sharma BK; Singh P; Sharma S
    J Enzyme Inhib Med Chem; 2006 Oct; 21(5):601-7. PubMed ID: 17194034
    [TBL] [Abstract][Full Text] [Related]  

  • 22. 1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.
    Sorbi C; Franchini S; Tait A; Prandi A; Gallesi R; Angeli P; Marucci G; Pirona L; Poggesi E; Brasili L
    ChemMedChem; 2009 Mar; 4(3):393-9. PubMed ID: 19152363
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Identification of critical determinants of alpha 1-adrenergic receptor subtype selective agonist binding.
    Hwa J; Graham RM; Perez DM
    J Biol Chem; 1995 Sep; 270(39):23189-95. PubMed ID: 7559466
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Design, synthesis, and biological activity of prazosin-related antagonists. Role of the piperazine and furan units of prazosin on the selectivity for alpha1-adrenoreceptor subtypes.
    Bolognesi ML; Budriesi R; Chiarini A; Poggesi E; Leonardi A; Melchiorre C
    J Med Chem; 1998 Nov; 41(24):4844-53. PubMed ID: 9822553
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety.
    Murali Dhar TG; Nagarathnam D; Marzabadi MR; Lagu B; Wong WC; Chiu G; Tyagarajan S; Miao SW; Zhang F; Sun W; Tian D; Shen Q; Zhang J; Wetzel JM; Forray C; Chang RS; Broten TP; Schorn TW; Chen TB; O'Malley S; Ransom R; Schneck K; Bendesky R; Harrell CM; Vyas KP
    J Med Chem; 1999 Nov; 42(23):4778-93. PubMed ID: 10579841
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Phenylalanine in the second membrane-spanning domain of alpha 1A-adrenergic receptor determines subtype selectivity of dihydropyridine antagonists.
    Hamaguchi N; True TA; Saussy DL; Jeffs PW
    Biochemistry; 1996 Nov; 35(45):14312-7. PubMed ID: 8916917
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling.
    Ishiguro M; Futabayashi Y; Ohnuki T; Ahmed M; Muramatsu I; Nagatomo T
    Life Sci; 2002 Oct; 71(21):2531-41. PubMed ID: 12270758
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion.
    Betti L; Floridi M; Giannaccini G; Manetti F; Paparelli C; Strappaghetti G; Botta M
    Bioorg Med Chem; 2004 Mar; 12(6):1527-35. PubMed ID: 15018926
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.
    Betti L; Corelli F; Floridi M; Giannaccini G; Maccari L; Manetti F; Strappaghetti G; Botta M
    J Med Chem; 2003 Jul; 46(16):3555-8. PubMed ID: 12877594
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors.
    Franchini S; Battisti UM; Baraldi A; Prandi A; Fossa P; Cichero E; Tait A; Sorbi C; Marucci G; Cilia A; Pirona L; Brasili L
    Eur J Med Chem; 2014 Nov; 87():248-66. PubMed ID: 25261823
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding.
    Nagaoka Y; Ahmed M; Hossain M; Bhuiyan MA; Ishiguro M; Nakamura T; Watanabe M; Nagatomo T
    J Pharmacol Sci; 2008 Jan; 106(1):114-20. PubMed ID: 18187928
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
    Balle T; Perregaard J; Ramirez MT; Larsen AK; Søby KK; Liljefors T; Andersen K
    J Med Chem; 2003 Jan; 46(2):265-83. PubMed ID: 12519065
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle.
    Piascik MT; Guarino RD; Smith MS; Soltis EE; Saussy DL; Perez DM
    J Pharmacol Exp Ther; 1995 Dec; 275(3):1583-9. PubMed ID: 8531132
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.
    Giardinà D; Crucianelli M; Romanelli R; Leonardi A; Poggesi E; Melchiorre C
    J Med Chem; 1996 Nov; 39(23):4602-7. PubMed ID: 8917649
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Ligand design for alpha(1) adrenoceptors.
    Bremner JB; Griffith R; Coban B
    Curr Med Chem; 2001 May; 8(6):607-20. PubMed ID: 11281844
    [TBL] [Abstract][Full Text] [Related]  

  • 36. ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes.
    Buckner SA; Milicic I; Daza AV; Meyer MD; Altenbach RJ; Williams M; Sullivan JP; Brioni JD
    Eur J Pharmacol; 2002 Aug; 449(1-2):159-65. PubMed ID: 12163120
    [TBL] [Abstract][Full Text] [Related]  

  • 37. New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.
    Fiorino F; Perissutti E; Severino B; Santagada V; Cirillo D; Terracciano S; Massarelli P; Bruni G; Collavoli E; Renner C; Caliendo G
    J Med Chem; 2005 Aug; 48(17):5495-503. PubMed ID: 16107148
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The role of alpha(1)-adrenoceptors and 5-HT(1A) receptors in the control of the micturition reflex in male anaesthetized rats.
    Conley RK; Williams TJ; Ford AP; Ramage AG
    Br J Pharmacol; 2001 May; 133(1):61-72. PubMed ID: 11325795
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
    Minarini A; Budriesi R; Chiarini A; Leonardi A; Melchiorre C
    Bioorg Med Chem Lett; 1998 Jun; 8(11):1353-8. PubMed ID: 9871765
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones.
    Nagarathnam D; Miao SW; Lagu B; Chiu G; Fang J; Murali Dhar TG; Zhang J; Tyagarajan S; Marzabadi MR; Zhang F; Wong WC; Sun W; Tian D; Wetzel JM; Forray C; Chang RS; Broten TP; Ransom RW; Schorn TW; Chen TB; O'Malley S; Kling P; Schneck K; Bendesky R; Harrell CM
    J Med Chem; 1999 Nov; 42(23):4764-77. PubMed ID: 10579840
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.