These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

164 related articles for article (PubMed ID: 15075403)

  • 1. Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis.
    Casbarra A; Birolo L; Infusini G; Dal Piaz F; Svensson M; Pucci P; Svanborg C; Marino G
    Protein Sci; 2004 May; 13(5):1322-30. PubMed ID: 15075403
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
    Svensson M; Fast J; Mossberg AK; Düringer C; Gustafsson L; Hallgren O; Brooks CL; Berliner L; Linse S; Svanborg C
    Protein Sci; 2003 Dec; 12(12):2794-804. PubMed ID: 14627739
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.
    Mossberg AK; Hun Mok K; Morozova-Roche LA; Svanborg C
    FEBS J; 2010 Nov; 277(22):4614-25. PubMed ID: 20977665
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex.
    Fast J; Mossberg AK; Svanborg C; Linse S
    Protein Sci; 2005 Feb; 14(2):329-40. PubMed ID: 15659367
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molten globule of bovine alpha-lactalbumin at neutral pH induced by heat, trifluoroethanol, and oleic acid: a comparative analysis by circular dichroism spectroscopy and limited proteolysis.
    Polverino de Laureto P; Frare E; Gottardo R; Fontana A
    Proteins; 2002 Nov; 49(3):385-97. PubMed ID: 12360528
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conversion of alpha-lactalbumin to a protein inducing apoptosis.
    Svensson M; Håkansson A; Mossberg AK; Linse S; Svanborg C
    Proc Natl Acad Sci U S A; 2000 Apr; 97(8):4221-6. PubMed ID: 10760289
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity.
    Ho CS; Rydstrom A; Manimekalai MS; Svanborg C; Grüber G
    PLoS One; 2012; 7(12):e53051. PubMed ID: 23300861
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes.
    Nakamura T; Aizawa T; Kariya R; Okada S; Demura M; Kawano K; Makabe K; Kuwajima K
    J Biol Chem; 2013 May; 288(20):14408-14416. PubMed ID: 23580643
    [TBL] [Abstract][Full Text] [Related]  

  • 9. HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.
    Svanborg C; Agerstam H; Aronson A; Bjerkvig R; Düringer C; Fischer W; Gustafsson L; Hallgren O; Leijonhuvud I; Linse S; Mossberg AK; Nilsson H; Pettersson J; Svensson M
    Adv Cancer Res; 2003; 88():1-29. PubMed ID: 12665051
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Compact oleic acid in HAMLET.
    Fast J; Mossberg AK; Nilsson H; Svanborg C; Akke M; Linse S
    FEBS Lett; 2005 Nov; 579(27):6095-100. PubMed ID: 16229842
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid.
    Knyazeva EL; Grishchenko VM; Fadeev RS; Akatov VS; Permyakov SE; Permyakov EA
    Biochemistry; 2008 Dec; 47(49):13127-37. PubMed ID: 19006329
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).
    Svensson M; Mossberg AK; Pettersson J; Linse S; Svanborg C
    Protein Sci; 2003 Dec; 12(12):2805-14. PubMed ID: 14627740
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Limited proteolysis of bovine alpha-lactalbumin: isolation and characterization of protein domains.
    Polverino de Laureto P; Scaramella E; Frigo M; Wondrich FG; De Filippis V; Zambonin M; Fontana A
    Protein Sci; 1999 Nov; 8(11):2290-303. PubMed ID: 10595532
    [TBL] [Abstract][Full Text] [Related]  

  • 14. alpha-Lactalbumin species variation, HAMLET formation, and tumor cell death.
    Pettersson J; Mossberg AK; Svanborg C
    Biochem Biophys Res Commun; 2006 Jun; 345(1):260-70. PubMed ID: 16678133
    [TBL] [Abstract][Full Text] [Related]  

  • 15. No need to be HAMLET or BAMLET to interact with histones: binding of monomeric alpha-lactalbumin to histones and basic poly-amino acids.
    Permyakov SE; Pershikova IV; Khokhlova TI; Uversky VN; Permyakov EA
    Biochemistry; 2004 May; 43(19):5575-82. PubMed ID: 15134431
    [TBL] [Abstract][Full Text] [Related]  

  • 16. alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding.
    Pettersson-Kastberg J; Mossberg AK; Trulsson M; Yong YJ; Min S; Lim Y; O'Brien JE; Svanborg C; Mok KH
    J Mol Biol; 2009 Dec; 394(5):994-1010. PubMed ID: 19766653
    [TBL] [Abstract][Full Text] [Related]  

  • 17. HAMLET in human milk is resistant to digestion and carries essential free long chain polyunsaturated fatty acids and oleic acid.
    Chetta KE; Forconi M; Newton DA; Wagner CL; Baatz JE
    Food Chem; 2023 Nov; 427():136752. PubMed ID: 37392621
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Applications of site-specific labeling to study HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid.
    Mercer N; Ramakrishnan B; Boeggeman E; Qasba PK
    PLoS One; 2011; 6(10):e26093. PubMed ID: 22016817
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HAMLET interacts with lipid membranes and perturbs their structure and integrity.
    Mossberg AK; Puchades M; Halskau Ø; Baumann A; Lanekoff I; Chao Y; Martinez A; Svanborg C; Karlsson R
    PLoS One; 2010 Feb; 5(2):e9384. PubMed ID: 20186341
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Conversion of human alpha-lactalbumin to an apo-like state in the complexes with basic poly-amino acids: toward understanding of the molecular mechanism of antitumor action of HAMLET.
    Permyakov SE; Pershikova IV; Zhadan AP; Goers J; Bakunts AG; Uversky VN; Berliner LJ; Permyakov EA
    J Proteome Res; 2005; 4(2):564-9. PubMed ID: 15822935
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.