183 related articles for article (PubMed ID: 15087400)
1. Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death.
Ogbourne SM; Suhrbier A; Jones B; Cozzi SJ; Boyle GM; Morris M; McAlpine D; Johns J; Scott TM; Sutherland KP; Gardner JM; Le TT; Lenarczyk A; Aylward JH; Parsons PG
Cancer Res; 2004 Apr; 64(8):2833-9. PubMed ID: 15087400
[TBL] [Abstract][Full Text] [Related]
2. Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate.
Challacombe JM; Suhrbier A; Parsons PG; Jones B; Hampson P; Kavanagh D; Rainger GE; Morris M; Lord JM; Le TT; Hoang-Le D; Ogbourne SM
J Immunol; 2006 Dec; 177(11):8123-32. PubMed ID: 17114487
[TBL] [Abstract][Full Text] [Related]
3. Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells.
Gillespie SK; Zhang XD; Hersey P
Mol Cancer Ther; 2004 Dec; 3(12):1651-8. PubMed ID: 15634659
[TBL] [Abstract][Full Text] [Related]
4. The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.
Li L; Shukla S; Lee A; Garfield SH; Maloney DJ; Ambudkar SV; Yuspa SH
Cancer Res; 2010 Jun; 70(11):4509-19. PubMed ID: 20460505
[TBL] [Abstract][Full Text] [Related]
5. The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner.
Hampson P; Kavanagh D; Smith E; Wang K; Lord JM; Ed Rainger G
Cancer Immunol Immunother; 2008 Aug; 57(8):1241-51. PubMed ID: 18265980
[TBL] [Abstract][Full Text] [Related]
6. Proceedings of the First International Conference on PEP005.
Ogbourne SM; Hampson P; Lord JM; Parsons P; De Witte PA; Suhrbier A
Anticancer Drugs; 2007 Mar; 18(3):357-62. PubMed ID: 17264770
[TBL] [Abstract][Full Text] [Related]
7. Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.
Benhadji KA; Serova M; Ghoul A; Cvitkovic E; Le Tourneau C; Ogbourne SM; Lokiec F; Calvo F; Hammel P; Faivre S; Raymond E
Br J Cancer; 2008 Dec; 99(11):1808-15. PubMed ID: 19034280
[TBL] [Abstract][Full Text] [Related]
8. The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity.
Ersvaer E; Kittang AO; Hampson P; Sand K; Gjertsen BT; Lord JM; Bruserud O
Toxins (Basel); 2010 Jan; 2(1):174-94. PubMed ID: 22069553
[TBL] [Abstract][Full Text] [Related]
9. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Hampson P; Chahal H; Khanim F; Hayden R; Mulder A; Assi LK; Bunce CM; Lord JM
Blood; 2005 Aug; 106(4):1362-8. PubMed ID: 15845901
[TBL] [Abstract][Full Text] [Related]
10. Skin cancer chemopreventive agent, {alpha}-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspase activation together with dissipation of mitochondrial membrane potential and cytochrome c release.
Kaur M; Agarwal C; Singh RP; Guan X; Dwivedi C; Agarwal R
Carcinogenesis; 2005 Feb; 26(2):369-80. PubMed ID: 15528219
[TBL] [Abstract][Full Text] [Related]
11. Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies.
Le TT; Gardner J; Hoang-Le D; Schmidt CW; MacDonald KP; Lambley E; Schroder WA; Ogbourne SM; Suhrbier A
Vaccine; 2009 May; 27(23):3053-62. PubMed ID: 19428919
[TBL] [Abstract][Full Text] [Related]
12. Subcellular localization of Photofrin determines the death phenotype of human epidermoid carcinoma A431 cells triggered by photodynamic therapy: when plasma membranes are the main targets.
Hsieh YJ; Wu CC; Chang CJ; Yu JS
J Cell Physiol; 2003 Mar; 194(3):363-75. PubMed ID: 12548556
[TBL] [Abstract][Full Text] [Related]
13. Increased Intracellular Reactive Oxygen Species Mediates the Anti-Cancer Effects of WZ35 via Activating Mitochondrial Apoptosis Pathway in Prostate Cancer Cells.
Chen M; Zhou B; Zhong P; Rajamanickam V; Dai X; Karvannan K; Zhou H; Zhang X; Liang G
Prostate; 2017 Apr; 77(5):489-504. PubMed ID: 27990666
[TBL] [Abstract][Full Text] [Related]
14. Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid.
Nasr P; Gursahani HI; Pang Z; Bondada V; Lee J; Hadley RW; Geddes JW
Neurochem Int; 2003 Jul; 43(2):89-99. PubMed ID: 12620277
[TBL] [Abstract][Full Text] [Related]
15. p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death.
Myatt SS; Redfern CP; Burchill SA
Clin Cancer Res; 2005 Apr; 11(8):3136-48. PubMed ID: 15837770
[TBL] [Abstract][Full Text] [Related]
16. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release.
Agarwal C; Singh RP; Agarwal R
Carcinogenesis; 2002 Nov; 23(11):1869-76. PubMed ID: 12419835
[TBL] [Abstract][Full Text] [Related]
17. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.
Regenass U; Mett H; Stanek J; Mueller M; Kramer D; Porter CW
Cancer Res; 1994 Jun; 54(12):3210-7. PubMed ID: 8205541
[TBL] [Abstract][Full Text] [Related]
18. Novel photosensitizers trigger rapid death of malignant human cells and rodent tumor transplants via lipid photodamage and membrane permeabilization.
Moisenovich MM; Ol'shevskaya VA; Rokitskaya TI; Ramonova AA; Nikitina RG; Savchenko AN; Tatarskiy VV; Kaplan MA; Kalinin VN; Kotova EA; Uvarov OV; Agapov II; Antonenko YN; Shtil AA
PLoS One; 2010 Sep; 5(9):e12717. PubMed ID: 20856679
[TBL] [Abstract][Full Text] [Related]
19. Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway.
Cozzi SJ; Parsons PG; Ogbourne SM; Pedley J; Boyle GM
Cancer Res; 2006 Oct; 66(20):10083-91. PubMed ID: 17047072
[TBL] [Abstract][Full Text] [Related]
20. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis.
Shidoji Y; Nakamura N; Moriwaki H; Muto Y
Biochem Biophys Res Commun; 1997 Jan; 230(1):58-63. PubMed ID: 9020060
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]