These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Morpholinoalkyl ester prodrugs of diclofenac: synthesis, in vitro and in vivo evaluation. Tammara VK; Narurkar MM; Crider AM; Khan MA J Pharm Sci; 1994 May; 83(5):644-8. PubMed ID: 8071813 [TBL] [Abstract][Full Text] [Related]
5. Design, synthesis, and biological evaluation of aromatic ester prodrugs of 1-(3'-hydroxypropyl)-2-methyl-3-hydroxypyridin-4-one (CP41) as orally active iron chelators. Liu ZD; Liu DY; Lu SL; Hider RC Arzneimittelforschung; 2000 May; 50(5):461-70. PubMed ID: 10858874 [TBL] [Abstract][Full Text] [Related]
6. A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs. Krise JP; Charman WN; Charman SA; Stella VJ J Pharm Sci; 1999 Sep; 88(9):928-32. PubMed ID: 10479356 [TBL] [Abstract][Full Text] [Related]
7. Synthesis and investigation of N4-substituted cytarabine derivatives as prodrugs. Fadl TA; Hasegawa T; Youssef AF; Farag HH; Omar FA; Kawaguchi T Pharmazie; 1995 Jun; 50(6):382-7. PubMed ID: 7651974 [TBL] [Abstract][Full Text] [Related]
8. Short-chain alkyl esters of L-dopa as prodrugs for rectal absorption. Fix JA; Alexander J; Cortese M; Engle K; Leppert P; Repta AJ Pharm Res; 1989 Jun; 6(6):501-5. PubMed ID: 2762226 [TBL] [Abstract][Full Text] [Related]
9. Evaluation of a targeted prodrug strategy of enhance oral absorption of poorly water-soluble compounds. Chan OH; Schmid HL; Stilgenbauer LA; Howson W; Horwell DC; Stewart BH Pharm Res; 1998 Jul; 15(7):1012-8. PubMed ID: 9688053 [TBL] [Abstract][Full Text] [Related]
10. In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate. Prueksaritanont T; Gorham LM; Breslin MJ; Hutchinson JH; Hartman GD; Vyas KP; Baillie TA Drug Metab Dispos; 1997 Aug; 25(8):978-84. PubMed ID: 9280406 [TBL] [Abstract][Full Text] [Related]
11. Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage. Sohma Y; Hayashi Y; Ito T; Matsumoto H; Kimura T; Kiso Y J Med Chem; 2003 Sep; 46(19):4124-35. PubMed ID: 12954064 [TBL] [Abstract][Full Text] [Related]
12. AS-924, a novel orally active bifunctional prodrug of ceftizoxime. Synthesis and relationship between physicochemical properties and oral absorption. Kasai M; Hatano S; Kitagawa M; Yoshimi A; Nishimura K; Mori N; Sakai A; Sugihara T Chem Pharm Bull (Tokyo); 1999 Aug; 47(8):1081-8. PubMed ID: 10478463 [TBL] [Abstract][Full Text] [Related]
13. Biopharmaceutic evaluation of furosemide as a potential candidate for a modified release peroral dosage form. Ritschel WA; Menon A; Sakr A Methods Find Exp Clin Pharmacol; 1991 Nov; 13(9):629-36. PubMed ID: 1787770 [TBL] [Abstract][Full Text] [Related]
14. The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption. Huttunen KM; Mannila A; Laine K; Kemppainen E; Leppänen J; Vepsäläinen J; Järvinen T; Rautio J J Med Chem; 2009 Jul; 52(14):4142-8. PubMed ID: 19522462 [TBL] [Abstract][Full Text] [Related]
15. Synthesis and evaluation of morpholinoalkyl ester prodrugs of indomethacin and naproxen. Tammara VK; Narurkar MM; Crider AM; Khan MA Pharm Res; 1993 Aug; 10(8):1191-9. PubMed ID: 8415407 [TBL] [Abstract][Full Text] [Related]
16. Prodrugs of 2',3'-dideoxyinosine (DDI): improved oral bioavailability via hydrophobic esters. Kawaguchi T; Hasegawa T; Seki T; Juni K; Morimoto Y; Miyakawa A; Saneyoshi M Chem Pharm Bull (Tokyo); 1992 May; 40(5):1338-40. PubMed ID: 1394659 [TBL] [Abstract][Full Text] [Related]
17. Physiological models are good tools to predict rat bioavailability of EF5154 prodrugs from in vitro intestinal parameters. Nomoto M; Tatebayashi T; Morita J; Suzuki H; Aizawa K; Kurosawa T; Komiya I J Pharm Sci; 2009 Apr; 98(4):1532-44. PubMed ID: 18683862 [TBL] [Abstract][Full Text] [Related]
18. Formulation and in vitro examination of furosemide containing suppositories and preliminary experiences of their clinical use. Regdon G; Fazekas T; Regdon G; Selmeczi B Pharmazie; 1996 Feb; 51(2):116-9. PubMed ID: 8720807 [TBL] [Abstract][Full Text] [Related]
19. Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone. Savolainen J; Leppanen J; Forsberg M; Taipale H; Nevalainen T; Huuskonen J; Gynther J; Mannisto PT; Jarvinen T Life Sci; 2000; 67(2):205-16. PubMed ID: 10901288 [TBL] [Abstract][Full Text] [Related]
20. Effect of group substitution on the physicochemical properties of ibuprofen prodrugs. Bansal AK; Khar RK; Dubey R; Sharma AK Pharmazie; 1994 Jun; 49(6):422-4. PubMed ID: 8047542 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]