BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 15123284)

  • 21. Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells.
    Honore S; Kamath K; Braguer D; Horwitz SB; Wilson L; Briand C; Jordan MA
    Cancer Res; 2004 Jul; 64(14):4957-64. PubMed ID: 15256469
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel.
    Matesanz R; Barasoain I; Yang CG; Wang L; Li X; de Inés C; Coderch C; Gago F; Barbero JJ; Andreu JM; Fang WS; Díaz JF
    Chem Biol; 2008 Jun; 15(6):573-85. PubMed ID: 18559268
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches.
    Canales A; Nieto L; Rodríguez-Salarichs J; Sánchez-Murcia PA; Coderch C; Cortés-Cabrera A; Paterson I; Carlomagno T; Gago F; Andreu JM; Altmann KH; Jiménez-Barbero J; Díaz JF
    ACS Chem Biol; 2014 Apr; 9(4):1033-43. PubMed ID: 24524625
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.
    Raccor BS; Vogt A; Sikorski RP; Madiraju C; Balachandran R; Montgomery K; Shin Y; Fukui Y; Jung WH; Curran DP; Day BW
    Mol Pharmacol; 2008 Mar; 73(3):718-26. PubMed ID: 18073274
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B.
    Navarrete KR; Alderete JB; Jiménez VA
    J Biomol Struct Dyn; 2015; 33(12):2530-40. PubMed ID: 26081685
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.
    O'Reilly T; Wartmann M; Brueggen J; Allegrini PR; Floersheimer A; Maira M; McSheehy PM
    Cancer Chemother Pharmacol; 2008 Nov; 62(6):1045-54. PubMed ID: 18301895
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Design, total synthesis, and evaluation of novel open-chain epothilone analogues.
    Alhamadsheh MM; Hudson RA; Viranga Tillekeratne LM
    Org Lett; 2006 Feb; 8(4):685-8. PubMed ID: 16468742
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Possible binding site for paclitaxel at microtubule pores.
    Magnani M; Maccari G; Andreu JM; Díaz JF; Botta M
    FEBS J; 2009 May; 276(10):2701-12. PubMed ID: 19459933
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Extended and clustered conformers of epothilone A.
    Rusinska-Roszak D; Tatka H; Pawlak R; Lozynski M
    J Phys Chem B; 2011 Apr; 115(13):3698-707. PubMed ID: 21405036
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Preclinical discovery of ixabepilone, a highly active antineoplastic agent.
    Lee FY; Borzilleri R; Fairchild CR; Kamath A; Smykla R; Kramer R; Vite G
    Cancer Chemother Pharmacol; 2008 Dec; 63(1):157-66. PubMed ID: 18347795
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone analogues.
    Taylor RE; Chen Y; Beatty A; Myles DC; Zhou Y
    J Am Chem Soc; 2003 Jan; 125(1):26-7. PubMed ID: 12515494
    [TBL] [Abstract][Full Text] [Related]  

  • 32. C-15 thiazol-4-yl analogues of (E)-9,10-didehydroepothilone D: synthesis and cytotoxicity.
    Hearn BR; Zhang D; Li Y; Myles DC
    Org Lett; 2006 Jul; 8(14):3057-9. PubMed ID: 16805551
    [TBL] [Abstract][Full Text] [Related]  

  • 33. New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.
    Borrelli S; Christodoulou MS; Ficarra I; Silvani A; Cappelletti G; Cartelli D; Damia G; Ricci F; Zucchetti M; Dosio F; Passarella D
    Eur J Med Chem; 2014 Oct; 85():179-90. PubMed ID: 25084144
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity.
    Pera B; Razzak M; Trigili C; Pineda O; Canales A; Buey RM; Jiménez-Barbero J; Northcote PT; Paterson I; Barasoain I; Díaz JF
    Chembiochem; 2010 Aug; 11(12):1669-78. PubMed ID: 20665616
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Mutations at leucine 215 of beta-tubulin affect paclitaxel sensitivity by two distinct mechanisms.
    Wang Y; Yin S; Blade K; Cooper G; Menick DR; Cabral F
    Biochemistry; 2006 Jan; 45(1):185-94. PubMed ID: 16388594
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone.
    Taylor RE; Chen Y; Galvin GM; Pabba PK
    Org Biomol Chem; 2004 Jan; 2(1):127-32. PubMed ID: 14737671
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping.
    Bennett MJ; Barakat K; Huzil JT; Tuszynski J; Schriemer DC
    Chem Biol; 2010 Jul; 17(7):725-34. PubMed ID: 20659685
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity.
    Kuzniewski CN; Gertsch J; Wartmann M; Altmann KH
    Org Lett; 2008 Mar; 10(6):1183-6. PubMed ID: 18303900
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route.
    Chou TC; Dong H; Zhang X; Tong WP; Danishefsky SJ
    Cancer Res; 2005 Oct; 65(20):9445-54. PubMed ID: 16230408
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Derivatization of the C12-C13 functional groups of epothilones A, B and C.
    Sefkow M; Kiffe M; Höfle G
    Bioorg Med Chem Lett; 1998 Nov; 8(21):3031-6. PubMed ID: 9873670
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.