516 related articles for article (PubMed ID: 15125690)
1. Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels.
Dong DL; Li Z; Wang HZ; Du ZM; Song WH; Yang BF
Basic Clin Pharmacol Toxicol; 2004 May; 94(5):209-12. PubMed ID: 15125690
[TBL] [Abstract][Full Text] [Related]
2. The influence of extracellular acidosis on the effect of IKr blockers.
Lin C; Ke X; Cvetanovic I; Ranade V; Somberg J
J Cardiovasc Pharmacol Ther; 2005 Mar; 10(1):67-76. PubMed ID: 15821840
[TBL] [Abstract][Full Text] [Related]
3. Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action.
Busch AE; Eigenberger B; Jurkiewicz NK; Salata JJ; Pica A; Suessbrich H; Lang F
Br J Pharmacol; 1998 Jan; 123(1):23-30. PubMed ID: 9484850
[TBL] [Abstract][Full Text] [Related]
4. The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents.
Lin C; Ke X; Cvetanovic I; Ranade V; Somberg J
Cardiology; 2007; 108(1):18-27. PubMed ID: 16960444
[TBL] [Abstract][Full Text] [Related]
5. Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.
Yang BF; Xu DH; Xu CQ; Li Z; Du ZM; Wang HZ; Dong DL
Acta Pharmacol Sin; 2004 May; 25(5):554-60. PubMed ID: 15132818
[TBL] [Abstract][Full Text] [Related]
6. Molecular determinants of dofetilide block of HERG K+ channels.
Ficker E; Jarolimek W; Kiehn J; Baumann A; Brown AM
Circ Res; 1998 Feb; 82(3):386-95. PubMed ID: 9486667
[TBL] [Abstract][Full Text] [Related]
7. Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis.
DU CY; El Harchi A; Zhang YH; Orchard CH; Hancox JC
J Cardiovasc Electrophysiol; 2011 Oct; 22(10):1163-70. PubMed ID: 21489024
[TBL] [Abstract][Full Text] [Related]
8. Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel.
Walker BD; Singleton CB; Tie H; Bursill JA; Wyse KR; Valenzuela SM; Breit SN; Campbell TJ
Cardiovasc Res; 2000 Oct; 48(1):44-58. PubMed ID: 11033107
[TBL] [Abstract][Full Text] [Related]
9. Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide.
Knobloch K; Brendel J; Peukert S; Rosenstein B; Busch AE; Wirth KJ
Naunyn Schmiedebergs Arch Pharmacol; 2002 Nov; 366(5):482-7. PubMed ID: 12382079
[TBL] [Abstract][Full Text] [Related]
10. High affinity open channel block by dofetilide of HERG expressed in a human cell line.
Snyders DJ; Chaudhary A
Mol Pharmacol; 1996 Jun; 49(6):949-55. PubMed ID: 8649354
[TBL] [Abstract][Full Text] [Related]
11. Open channel block by KCB-328 [1-(2-amino-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane hydrochloride] of the heterologously expressed human ether-a-go-go-related gene K+ channels.
Park JB; Choe H; Lee YK; Ha KC; Rhee KS; Ko JK; Joo CU; Chae SW; Kwak YG
J Pharmacol Exp Ther; 2002 Jul; 302(1):314-9. PubMed ID: 12065732
[TBL] [Abstract][Full Text] [Related]
12. Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide.
Kiehn J; Lacerda AE; Wible B; Brown AM
Circulation; 1996 Nov; 94(10):2572-9. PubMed ID: 8921803
[TBL] [Abstract][Full Text] [Related]
13. Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels.
Ficker E; Jarolimek W; Brown AM
Mol Pharmacol; 2001 Dec; 60(6):1343-8. PubMed ID: 11723241
[TBL] [Abstract][Full Text] [Related]
14. High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872.
Thomas D; Wendt-Nordahl G; Röckl K; Ficker E; Brown AM; Kiehn J
J Pharmacol Exp Ther; 2001 May; 297(2):753-61. PubMed ID: 11303067
[TBL] [Abstract][Full Text] [Related]
15. The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
Diaz GJ; Daniell K; Leitza ST; Martin RL; Su Z; McDermott JS; Cox BF; Gintant GA
J Pharmacol Toxicol Methods; 2004; 50(3):187-99. PubMed ID: 15519905
[TBL] [Abstract][Full Text] [Related]
16. Dofetilide block involves interactions with open and inactivated states of HERG channels.
Weerapura M; Hébert TE; Nattel S
Pflugers Arch; 2002 Feb; 443(4):520-31. PubMed ID: 11907818
[TBL] [Abstract][Full Text] [Related]
17. Use-dependent 'agonist' effect of azimilide on the HERG channel.
Jiang M; Dun W; Fan JS; Tseng GN
J Pharmacol Exp Ther; 1999 Dec; 291(3):1324-36. PubMed ID: 10565858
[TBL] [Abstract][Full Text] [Related]
18. Modulation of HERG potassium channels by extracellular magnesium and quinidine.
Po SS; Wang DW; Yang IC; Johnson JP; Nie L; Bennett PB
J Cardiovasc Pharmacol; 1999 Feb; 33(2):181-5. PubMed ID: 10028924
[TBL] [Abstract][Full Text] [Related]
19. Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels.
Limberis JT; Su Z; Cox BF; Gintant GA; Martin RL
Clin Exp Pharmacol Physiol; 2006 Nov; 33(11):1059-65. PubMed ID: 17042915
[TBL] [Abstract][Full Text] [Related]
20. A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels.
Lin C; Cvetanovic I; Ke X; Ranade V; Somberg J
Am J Ther; 2005; 12(4):328-36. PubMed ID: 16041196
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]