50 related articles for article (PubMed ID: 15125970)
1. Evaluation of series of isobenzofuranone dimers as PKCalpha ligands: implication for the distance between the two ligand binding sites.
Baba Y; Mayumi S; Hirai G; Kawasaki H; Ogoshi Y; Yanagisawa T; Hashimoto Y; Sodeoka M
Bioorg Med Chem Lett; 2004 Jun; 14(11):2969-72. PubMed ID: 15125970
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis, and structure-activity relationship of new isobenzofuranone ligands of protein kinase C.
Baba Y; Ogoshi Y; Hirai G; Yanagisawa T; Nagamatsu K; Mayumi S; Hashimoto Y; Sodeoka M
Bioorg Med Chem Lett; 2004 Jun; 14(11):2963-7. PubMed ID: 15125969
[TBL] [Abstract][Full Text] [Related]
3. New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
Sridhar J; Wei ZL; Nowak I; Lewin NE; Ayres JA; Pearce LV; Blumberg PM; Kozikowski AP
J Med Chem; 2003 Sep; 46(19):4196-204. PubMed ID: 12954072
[TBL] [Abstract][Full Text] [Related]
4. Retinoids as ligands and coactivators of protein kinase C alpha.
Imam A; Hoyos B; Swenson C; Levi E; Chua R; Viriya E; Hammerling U
FASEB J; 2001 Jan; 15(1):28-30. PubMed ID: 11099483
[TBL] [Abstract][Full Text] [Related]
5. Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.
Chen J; Deng F; Li J; Wang QJ
Biochem J; 2008 Apr; 411(2):333-42. PubMed ID: 18076381
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.
Boije af Gennäs G; Talman V; Aitio O; Ekokoski E; Finel M; Tuominen RK; Yli-Kauhaluoma J
J Med Chem; 2009 Jul; 52(13):3969-81. PubMed ID: 19438240
[TBL] [Abstract][Full Text] [Related]
7. Differential roles of the tandem C1 domains of protein kinase C delta in the biphasic down-regulation induced by bryostatin 1.
Lorenzo PS; Bögi K; Hughes KM; Beheshti M; Bhattacharyya D; Garfield SH; Pettit GR; Blumberg PM
Cancer Res; 1999 Dec; 59(24):6137-44. PubMed ID: 10626804
[TBL] [Abstract][Full Text] [Related]
8. Contribution of the C1A and C1B domains to the membrane interaction of protein kinase C.
Giorgione J; Hysell M; Harvey DF; Newton AC
Biochemistry; 2003 Sep; 42(38):11194-202. PubMed ID: 14503869
[TBL] [Abstract][Full Text] [Related]
9. Identification of potent, selective protein kinase C inhibitors based on a phorbol skeleton.
Yamatsugu K; Motoki R; Kanai M; Shibasaki M
Chem Asian J; 2006 Sep; 1(3):314-21. PubMed ID: 17441066
[TBL] [Abstract][Full Text] [Related]
10. Effects of ethanol on protein kinase C alpha activity induced by association with Rho GTPases.
Slater SJ; Cook AC; Seiz JL; Malinowski SA; Stagliano BA; Stubbs CD
Biochemistry; 2003 Oct; 42(41):12105-14. PubMed ID: 14556642
[TBL] [Abstract][Full Text] [Related]
11. Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions.
Hirai G; Ohkubo M; Tamura Y; Sodeoka M
Bioorg Med Chem Lett; 2011 Jun; 21(12):3587-90. PubMed ID: 21596562
[TBL] [Abstract][Full Text] [Related]
12. Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
Le XF; Marcelli M; McWatters A; Nan B; Mills GB; O'Brian CA; Bast RC
Oncogene; 2001 Dec; 20(57):8258-69. PubMed ID: 11781840
[TBL] [Abstract][Full Text] [Related]
13. Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C.
Wang S; Kazanietz MG; Blumberg PM; Marquez VE; Milne GW
J Med Chem; 1996 Jun; 39(13):2541-53. PubMed ID: 8691452
[TBL] [Abstract][Full Text] [Related]
14. A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold.
Lee JH; Nandy SK; Lawrence DS
J Am Chem Soc; 2004 Mar; 126(11):3394-5. PubMed ID: 15025445
[TBL] [Abstract][Full Text] [Related]
15. Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha.
Ochoa WF; Corbalán-Garcia S; Eritja R; Rodríguez-Alfaro JA; Gómez-Fernández JC; Fita I; Verdaguer N
J Mol Biol; 2002 Jul; 320(2):277-91. PubMed ID: 12079385
[TBL] [Abstract][Full Text] [Related]
16. Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions.
Bertolini TM; Giorgione J; Harvey DF; Newton AC
J Org Chem; 2003 Jun; 68(13):5028-36. PubMed ID: 12816455
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Calpha-regulatory domain lying outside of the pseudosubstrate sequence.
Kirwan AF; Bibby AC; Mvilongo T; Riedel H; Burke T; Millis SZ; Parissenti AM
Biochem J; 2003 Jul; 373(Pt 2):571-81. PubMed ID: 12710889
[TBL] [Abstract][Full Text] [Related]
18. Antisense inhibition of protein kinase Calpha reverses the transformed phenotype in human lung carcinoma cells.
Wang XY; Repasky E; Liu HT
Exp Cell Res; 1999 Jul; 250(1):253-63. PubMed ID: 10388539
[TBL] [Abstract][Full Text] [Related]
19. Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D.
Wang QJ; Fang TW; Yang D; Lewin NE; Van Lint J; Marquez VE; Blumberg PM
Mol Pharmacol; 2003 Dec; 64(6):1342-8. PubMed ID: 14645664
[TBL] [Abstract][Full Text] [Related]
20. Spanning binding sites on allosteric proteins with polymer-linked ligand dimers.
Kramer RH; Karpen JW
Nature; 1998 Oct; 395(6703):710-3. PubMed ID: 9790193
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
