These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 15128703)

  • 1. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
    Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; Serneels L; Saftig P; Craessaerts K; De Strooper B; Hartmann D
    Hum Mol Genet; 2004 Jul; 13(13):1321-31. PubMed ID: 15128703
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
    Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
    Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

  • 5. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
    Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.
    Qyang Y; Chambers SM; Wang P; Xia X; Chen X; Goodell MA; Zheng H
    Biochemistry; 2004 May; 43(18):5352-9. PubMed ID: 15122901
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
    Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Presenilin function and gamma-secretase activity.
    Brunkan AL; Goate AM
    J Neurochem; 2005 May; 93(4):769-92. PubMed ID: 15857382
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
    Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; Wilson CA; Lee VM; Doms RW
    Biochemistry; 2004 Mar; 43(12):3555-63. PubMed ID: 15035625
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT; Crouthamel MC; DiMuzio J; Pietrak BL; Donoviel DB; Bernstein A; Gardell SJ; Li YM; Hazuda D
    J Neurochem; 2006 Jan; 96(1):118-25. PubMed ID: 16300640
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 14. [Beta-amyloid protein: recent progress in basic research and therapeutic approaches].
    Iwatsubo T
    Rinsho Shinkeigaku; 2001 Dec; 41(12):1198-200. PubMed ID: 12235837
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
    Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
    Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
    Selkoe DJ
    Proc Natl Acad Sci U S A; 2001 Sep; 98(20):11039-41. PubMed ID: 11572965
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.
    Brunkan AL; Martinez M; Wang J; Walker ES; Beher D; Shearman MS; Goate AM
    J Neurochem; 2005 Sep; 94(5):1315-28. PubMed ID: 16001967
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.
    Oh YS; Turner RJ
    Biochem Biophys Res Commun; 2006 Jul; 346(1):330-4. PubMed ID: 16756946
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.