754 related articles for article (PubMed ID: 15128949)
1. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.
Gao Y; Dickerson JB; Guo F; Zheng J; Zheng Y
Proc Natl Acad Sci U S A; 2004 May; 101(20):7618-23. PubMed ID: 15128949
[TBL] [Abstract][Full Text] [Related]
2. Rational design and applications of a Rac GTPase-specific small molecule inhibitor.
Akbar H; Cancelas J; Williams DA; Zheng J; Zheng Y
Methods Enzymol; 2006; 406():554-65. PubMed ID: 16472687
[TBL] [Abstract][Full Text] [Related]
3. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.
Debreceni B; Gao Y; Guo F; Zhu K; Jia B; Zheng Y
J Biol Chem; 2004 Jan; 279(5):3777-86. PubMed ID: 14597635
[TBL] [Abstract][Full Text] [Related]
4. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.
Stankiewicz TR; Ramaswami SA; Bouchard RJ; Aktories K; Linseman DA
J Biol Chem; 2015 Apr; 290(15):9363-76. PubMed ID: 25666619
[TBL] [Abstract][Full Text] [Related]
5. Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
Nassar N; Cancelas J; Zheng J; Williams DA; Zheng Y
Curr Top Med Chem; 2006; 6(11):1109-16. PubMed ID: 16842149
[TBL] [Abstract][Full Text] [Related]
6. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice.
Zins K; Lucas T; Reichl P; Abraham D; Aharinejad S
PLoS One; 2013; 8(9):e74924. PubMed ID: 24040362
[TBL] [Abstract][Full Text] [Related]
7. Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors.
Gao Y; Xing J; Streuli M; Leto TL; Zheng Y
J Biol Chem; 2001 Dec; 276(50):47530-41. PubMed ID: 11595749
[TBL] [Abstract][Full Text] [Related]
8. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
Montalvo-Ortiz BL; Castillo-Pichardo L; Hernández E; Humphries-Bickley T; De la Mota-Peynado A; Cubano LA; Vlaar CP; Dharmawardhane S
J Biol Chem; 2012 Apr; 287(16):13228-38. PubMed ID: 22383527
[TBL] [Abstract][Full Text] [Related]
9. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
Shutes A; Onesto C; Picard V; Leblond B; Schweighoffer F; Der CJ
J Biol Chem; 2007 Dec; 282(49):35666-78. PubMed ID: 17932039
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice.
Yao HY; Chen L; Xu C; Wang J; Chen J; Xie QM; Wu X; Yan XF
Biochim Biophys Acta; 2011 Jul; 1810(7):666-74. PubMed ID: 21511011
[TBL] [Abstract][Full Text] [Related]
11. Novel inhibitors of Rac1 in metastatic breast cancer.
Hernández E; De La Mota-Peynado A; Dharmawardhane S; Vlaar CP
P R Health Sci J; 2010 Dec; 29(4):348-56. PubMed ID: 21261173
[TBL] [Abstract][Full Text] [Related]
12. Development of EHop-016: a small molecule inhibitor of Rac.
Dharmawardhane S; Hernandez E; Vlaar C
Enzymes; 2013; 33 Pt A(Pt A):117-46. PubMed ID: 25033803
[TBL] [Abstract][Full Text] [Related]
13. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.
Leeuwen FN; Kain HE; Kammen RA; Michiels F; Kranenburg OW; Collard JG
J Cell Biol; 1997 Nov; 139(3):797-807. PubMed ID: 9348295
[TBL] [Abstract][Full Text] [Related]
14. The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.
Boissier P; Huynh-Do U
Cell Signal; 2014 Mar; 26(3):483-91. PubMed ID: 24308970
[TBL] [Abstract][Full Text] [Related]
15. [Role of the multifunctional Trio protein in the control of the Rac1 and RhoA gtpase signaling pathways].
Bellanger JM; Zugasti O; Lazaro JB; Diriong S; Lamb N; Sardet C; Debant A
C R Seances Soc Biol Fil; 1998; 192(2):367-74. PubMed ID: 9759378
[TBL] [Abstract][Full Text] [Related]
16. RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.
De P; Carlson JH; Jepperson T; Willis S; Leyland-Jones B; Dey N
Oncotarget; 2017 Jan; 8(2):3072-3103. PubMed ID: 27902969
[TBL] [Abstract][Full Text] [Related]
17. Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
Ugolev Y; Berdichevsky Y; Weinbaum C; Pick E
J Biol Chem; 2008 Aug; 283(32):22257-71. PubMed ID: 18505730
[TBL] [Abstract][Full Text] [Related]
18. Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors.
Li R; Zheng Y
J Biol Chem; 1997 Feb; 272(8):4671-9. PubMed ID: 9030518
[TBL] [Abstract][Full Text] [Related]
19. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
Martin H; Mali RS; Ma P; Chatterjee A; Ramdas B; Sims E; Munugalavadla V; Ghosh J; Mattingly RR; Visconte V; Tiu RV; Vlaar CP; Dharmawardhane S; Kapur R
J Clin Invest; 2013 Oct; 123(10):4449-63. PubMed ID: 24091327
[TBL] [Abstract][Full Text] [Related]
20. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.
Guo X; Stafford LJ; Bryan B; Xia C; Ma W; Wu X; Liu D; Songyang Z; Liu M
J Biol Chem; 2003 Apr; 278(15):13207-15. PubMed ID: 12547822
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
