These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

165 related articles for article (PubMed ID: 15139041)

  • 1. Mechanism for ribonucleotide reductase inactivation by the anticancer drug gemcitabine.
    Pereira S; Fernandes PA; Ramos MJ
    J Comput Chem; 2004 Jul; 25(10):1286-94. PubMed ID: 15139041
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Understanding ribonucleotide reductase inactivation by gemcitabine.
    Cerqueira NM; Fernandes PA; Ramos MJ
    Chemistry; 2007; 13(30):8507-15. PubMed ID: 17636467
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate.
    van der Donk WA; Yu G; Pérez L; Sanchez RJ; Stubbe J; Samano V; Robins MJ
    Biochemistry; 1998 May; 37(18):6419-26. PubMed ID: 9572859
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant.
    Artin E; Wang J; Lohman GJ; Yokoyama K; Yu G; Griffin RG; Bar G; Stubbe J
    Biochemistry; 2009 Dec; 48(49):11622-9. PubMed ID: 19899770
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.
    Wang J; Lohman GJ; Stubbe J
    Proc Natl Acad Sci U S A; 2007 Sep; 104(36):14324-9. PubMed ID: 17726094
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.
    Zhou B; Su L; Hu S; Hu W; Yip ML; Wu J; Gaur S; Smith DL; Yuan YC; Synold TW; Horne D; Yen Y
    Cancer Res; 2013 Nov; 73(21):6484-93. PubMed ID: 24072748
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors.
    van der Donk WA; Yu G; Silva DJ; Stubbe J; McCarthy JR; Jarvi ET; Matthews DP; Resvick RJ; Wagner E
    Biochemistry; 1996 Jun; 35(25):8381-91. PubMed ID: 8679596
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.
    Fujii N; Evison BJ; Actis ML; Inoue A
    Bioorg Med Chem; 2015 Nov; 23(21):6912-21. PubMed ID: 26462050
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical.
    Lohman GJ; Gerfen GJ; Stubbe J
    Biochemistry; 2010 Feb; 49(7):1396-403. PubMed ID: 20088568
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification.
    Lohman GJ; Stubbe J
    Biochemistry; 2010 Feb; 49(7):1404-17. PubMed ID: 20088569
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation.
    Silva DJ; Stubbe J; Samano V; Robins MJ
    Biochemistry; 1998 Apr; 37(16):5528-35. PubMed ID: 9548936
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Modeling and Proposed Molecular Mechanism of Hydroxyurea Through Docking and Molecular Dynamic Simulation to Curtail the Action of Ribonucleotide Reductase.
    Iman M; Khansefid Z; Davood A
    Recent Pat Anticancer Drug Discov; 2016; 11(4):461-468. PubMed ID: 27670694
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy.
    Cerqueira NM; Pereira S; Fernandes PA; Ramos MJ
    Curr Med Chem; 2005; 12(11):1283-94. PubMed ID: 15974997
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs.
    Plamthottam S; Sun D; Van Valkenburgh J; Valenzuela J; Ruehle B; Steele D; Poddar S; Marshalik M; Hernandez S; Radu CG; Zink JI
    J Biol Inorg Chem; 2019 Aug; 24(5):621-632. PubMed ID: 31250199
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The relationship between the antitumor activity and the ribonucleotide reductase inhibitory activity of (E)-2'-deoxy-2'-(fluoromethylene) cytidine, MDL 101,731.
    Kanazawa J; Takahashi T; Akinaga S; Tamaoki T; Okabe M
    Anticancer Drugs; 1998 Aug; 9(7):653-7. PubMed ID: 9773810
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Enzyme ribonucleotide reductase: unraveling an enigmatic paradigm of enzyme inhibition by furanone derivatives.
    Cerqueira NM; Fernandes PA; Ramos MJ
    J Phys Chem B; 2006 Oct; 110(42):21272-81. PubMed ID: 17048956
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Theoretical studies on the mechanism of inhibition of Ribonucleotide Reductase by (E)-2'-Fluoromethylene-2'-deoxycitidine-5'-diphosphate.
    Fernandes PA; Ramos MJ
    J Am Chem Soc; 2003 May; 125(20):6311-22. PubMed ID: 12785865
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.
    Sigmond J; Kamphuis JA; Laan AC; Hoebe EK; Bergman AM; Peters GJ
    Biochem Pharmacol; 2007 May; 73(10):1548-57. PubMed ID: 17324380
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.
    Xu H; Faber C; Uchiki T; Racca J; Dealwis C
    Proc Natl Acad Sci U S A; 2006 Mar; 103(11):4028-33. PubMed ID: 16537480
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Theoretical study on the inhibition of ribonucleotide reductase by 2'-mercapto-2'-deoxyribonucleoside-5'-diphosphates.
    Pereira S; Fernandes PA; Ramos MJ
    J Am Chem Soc; 2005 Apr; 127(14):5174-9. PubMed ID: 15810852
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.