172 related articles for article (PubMed ID: 15139041)
1. Mechanism for ribonucleotide reductase inactivation by the anticancer drug gemcitabine.
Pereira S; Fernandes PA; Ramos MJ
J Comput Chem; 2004 Jul; 25(10):1286-94. PubMed ID: 15139041
[TBL] [Abstract][Full Text] [Related]
2. Understanding ribonucleotide reductase inactivation by gemcitabine.
Cerqueira NM; Fernandes PA; Ramos MJ
Chemistry; 2007; 13(30):8507-15. PubMed ID: 17636467
[TBL] [Abstract][Full Text] [Related]
3. Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate.
van der Donk WA; Yu G; Pérez L; Sanchez RJ; Stubbe J; Samano V; Robins MJ
Biochemistry; 1998 May; 37(18):6419-26. PubMed ID: 9572859
[TBL] [Abstract][Full Text] [Related]
4. Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.
Wang J; Lohman GJ; Stubbe J
Proc Natl Acad Sci U S A; 2007 Sep; 104(36):14324-9. PubMed ID: 17726094
[TBL] [Abstract][Full Text] [Related]
5. Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant.
Artin E; Wang J; Lohman GJ; Yokoyama K; Yu G; Griffin RG; Bar G; Stubbe J
Biochemistry; 2009 Dec; 48(49):11622-9. PubMed ID: 19899770
[TBL] [Abstract][Full Text] [Related]
6. A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.
Zhou B; Su L; Hu S; Hu W; Yip ML; Wu J; Gaur S; Smith DL; Yuan YC; Synold TW; Horne D; Yen Y
Cancer Res; 2013 Nov; 73(21):6484-93. PubMed ID: 24072748
[TBL] [Abstract][Full Text] [Related]
7. Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors.
van der Donk WA; Yu G; Silva DJ; Stubbe J; McCarthy JR; Jarvi ET; Matthews DP; Resvick RJ; Wagner E
Biochemistry; 1996 Jun; 35(25):8381-91. PubMed ID: 8679596
[TBL] [Abstract][Full Text] [Related]
8. A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.
Fujii N; Evison BJ; Actis ML; Inoue A
Bioorg Med Chem; 2015 Nov; 23(21):6912-21. PubMed ID: 26462050
[TBL] [Abstract][Full Text] [Related]
9. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification.
Lohman GJ; Stubbe J
Biochemistry; 2010 Feb; 49(7):1404-17. PubMed ID: 20088569
[TBL] [Abstract][Full Text] [Related]
10. Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical.
Lohman GJ; Gerfen GJ; Stubbe J
Biochemistry; 2010 Feb; 49(7):1396-403. PubMed ID: 20088568
[TBL] [Abstract][Full Text] [Related]
11. Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation.
Silva DJ; Stubbe J; Samano V; Robins MJ
Biochemistry; 1998 Apr; 37(16):5528-35. PubMed ID: 9548936
[TBL] [Abstract][Full Text] [Related]
12. Modeling and Proposed Molecular Mechanism of Hydroxyurea Through Docking and Molecular Dynamic Simulation to Curtail the Action of Ribonucleotide Reductase.
Iman M; Khansefid Z; Davood A
Recent Pat Anticancer Drug Discov; 2016; 11(4):461-468. PubMed ID: 27670694
[TBL] [Abstract][Full Text] [Related]
13. Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy.
Cerqueira NM; Pereira S; Fernandes PA; Ramos MJ
Curr Med Chem; 2005; 12(11):1283-94. PubMed ID: 15974997
[TBL] [Abstract][Full Text] [Related]
14. Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs.
Plamthottam S; Sun D; Van Valkenburgh J; Valenzuela J; Ruehle B; Steele D; Poddar S; Marshalik M; Hernandez S; Radu CG; Zink JI
J Biol Inorg Chem; 2019 Aug; 24(5):621-632. PubMed ID: 31250199
[TBL] [Abstract][Full Text] [Related]
15. The relationship between the antitumor activity and the ribonucleotide reductase inhibitory activity of (E)-2'-deoxy-2'-(fluoromethylene) cytidine, MDL 101,731.
Kanazawa J; Takahashi T; Akinaga S; Tamaoki T; Okabe M
Anticancer Drugs; 1998 Aug; 9(7):653-7. PubMed ID: 9773810
[TBL] [Abstract][Full Text] [Related]
16. Enzyme ribonucleotide reductase: unraveling an enigmatic paradigm of enzyme inhibition by furanone derivatives.
Cerqueira NM; Fernandes PA; Ramos MJ
J Phys Chem B; 2006 Oct; 110(42):21272-81. PubMed ID: 17048956
[TBL] [Abstract][Full Text] [Related]
17. Theoretical studies on the mechanism of inhibition of Ribonucleotide Reductase by (E)-2'-Fluoromethylene-2'-deoxycitidine-5'-diphosphate.
Fernandes PA; Ramos MJ
J Am Chem Soc; 2003 May; 125(20):6311-22. PubMed ID: 12785865
[TBL] [Abstract][Full Text] [Related]
18. The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.
Sigmond J; Kamphuis JA; Laan AC; Hoebe EK; Bergman AM; Peters GJ
Biochem Pharmacol; 2007 May; 73(10):1548-57. PubMed ID: 17324380
[TBL] [Abstract][Full Text] [Related]
19. Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.
Xu H; Faber C; Uchiki T; Racca J; Dealwis C
Proc Natl Acad Sci U S A; 2006 Mar; 103(11):4028-33. PubMed ID: 16537480
[TBL] [Abstract][Full Text] [Related]
20. Theoretical study on the inhibition of ribonucleotide reductase by 2'-mercapto-2'-deoxyribonucleoside-5'-diphosphates.
Pereira S; Fernandes PA; Ramos MJ
J Am Chem Soc; 2005 Apr; 127(14):5174-9. PubMed ID: 15810852
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
