583 related articles for article (PubMed ID: 15139774)
1. Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes.
Babizhayev MA; Deyev AI; Yermakova VN; Brikman IV; Bours J
Drugs R D; 2004; 5(3):125-39. PubMed ID: 15139774
[TBL] [Abstract][Full Text] [Related]
2. Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.
Babizhayev MA
Drugs R D; 2005; 6(6):345-69. PubMed ID: 16274259
[TBL] [Abstract][Full Text] [Related]
3. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.
Babizhayev MA
Drug Metabol Drug Interact; 2009; 24(2-4):275-323. PubMed ID: 20408504
[TBL] [Abstract][Full Text] [Related]
4. State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
Babizhayev MA; Kasus-Jacobi A
Curr Clin Pharmacol; 2009 Jan; 4(1):4-37. PubMed ID: 19149498
[TBL] [Abstract][Full Text] [Related]
5. N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients.
Babizhayev MA; Micans P; Guiotto A; Kasus-Jacobi A
Am J Ther; 2009; 16(6):517-33. PubMed ID: 19487926
[TBL] [Abstract][Full Text] [Related]
6. Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.
Babizhayev MA
Cell Biochem Funct; 2011 Apr; 29(3):183-206. PubMed ID: 21381059
[TBL] [Abstract][Full Text] [Related]
7. N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.
Babizhayev MA; Burke L; Micans P; Richer SP
Clin Interv Aging; 2009; 4():31-50. PubMed ID: 19503764
[TBL] [Abstract][Full Text] [Related]
8. Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
Babizhayev MA; Yegorov YE
Recent Pat Drug Deliv Formul; 2016; 10(2):82-129. PubMed ID: 26084629
[TBL] [Abstract][Full Text] [Related]
9. Biomarkers of oxidative stress and cataract. Novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: anti-cataract which helps to prevent and treat cataracts in the eyes of dogs and other animals.
Babizhayev MA; Yegorov YE
Curr Drug Deliv; 2014; 11(1):24-61. PubMed ID: 24783234
[TBL] [Abstract][Full Text] [Related]
10. Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.
Babizhayev MA
Fundam Clin Pharmacol; 2012 Feb; 26(1):86-117. PubMed ID: 21883446
[TBL] [Abstract][Full Text] [Related]
11. Lipid peroxidation as a possible cause of cataract.
Babizhayev MA; Deyev AI; Linberg LF
Mech Ageing Dev; 1988 Jul; 44(1):69-89. PubMed ID: 3205065
[TBL] [Abstract][Full Text] [Related]
12. Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous.
Babizhayev MA; Vishnyakova KS; Yegorov YE
Fundam Clin Pharmacol; 2011 Apr; 25(2):139-62. PubMed ID: 20412312
[TBL] [Abstract][Full Text] [Related]
13. The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study.
Williams DL; Munday P
Vet Ophthalmol; 2006; 9(5):311-6. PubMed ID: 16939459
[TBL] [Abstract][Full Text] [Related]
14. Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care.
Babizhayev MA; Khoroshilova-Maslova IP; Kasus-Jacobi A
Fundam Clin Pharmacol; 2012 Oct; 26(5):644-78. PubMed ID: 21793899
[TBL] [Abstract][Full Text] [Related]
15. Reactive Oxygen Species and the Aging Eye: Specific Role of Metabolically Active Mitochondria in Maintaining Lens Function and in the Initiation of the Oxidation-Induced Maturity Onset Cataract--A Novel Platform of Mitochondria-Targeted Antioxidants With Broad Therapeutic Potential for Redox Regulation and Detoxification of Oxidants in Eye Diseases.
Babizhayev MA; Yegorov YE
Am J Ther; 2016; 23(1):e98-117. PubMed ID: 21048433
[TBL] [Abstract][Full Text] [Related]
16. Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
Babizhayev MA
Recent Pat Drug Deliv Formul; 2012 Aug; 6(2):107-48. PubMed ID: 22436026
[TBL] [Abstract][Full Text] [Related]
17. Failure to withstand oxidative stress induced by phospholipid hydroperoxides as a possible cause of the lens opacities in systemic diseases and ageing.
Babizhayev MA
Biochim Biophys Acta; 1996 Mar; 1315(2):87-99. PubMed ID: 8608175
[TBL] [Abstract][Full Text] [Related]
18. N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications.
Babizhayev MA; Guiotto A; Kasus-Jacobi A
J Drug Target; 2009 Jan; 17(1):36-63. PubMed ID: 19037813
[TBL] [Abstract][Full Text] [Related]
19. The natural histidine-containing dipeptide Nalpha-acetylcarnosine as an antioxidant for ophthalmic use.
Babizhayev MA; Yermakova VN; Semiletov YA; Deyev AI
Biochemistry (Mosc); 2000 May; 65(5):588-98. PubMed ID: 10851037
[TBL] [Abstract][Full Text] [Related]
20. Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform.
Babizhayev MA
Drug Test Anal; 2012 Jun; 4(6):468-85. PubMed ID: 21416634
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]