BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 15147191)

  • 1. Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries.
    Bernat B; Sun M; Dwyer M; Feldkamp M; Kossiakoff AA
    Biochemistry; 2004 May; 43(20):6076-84. PubMed ID: 15147191
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
    Schiffer C; Ultsch M; Walsh S; Somers W; de Vos AM; Kossiakoff A
    J Mol Biol; 2002 Feb; 316(2):277-89. PubMed ID: 11851338
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis.
    Pál G; Fong SY; Kossiakoff AA; Sidhu SS
    Protein Sci; 2005 Sep; 14(9):2405-13. PubMed ID: 16131663
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Affinity maturation of human growth hormone by monovalent phage display.
    Lowman HB; Wells JA
    J Mol Biol; 1993 Dec; 234(3):564-78. PubMed ID: 8254660
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis.
    Vajdos FF; Adams CW; Breece TN; Presta LG; de Vos AM; Sidhu SS
    J Mol Biol; 2002 Jul; 320(2):415-28. PubMed ID: 12079396
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry.
    Horn JR; Kraybill B; Petro EJ; Coales SJ; Morrow JA; Hamuro Y; Kossiakoff AA
    Biochemistry; 2006 Jul; 45(28):8488-98. PubMed ID: 16834322
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High-density mutagenesis by combined DNA shuffling and phage display to assign essential amino acid residues in protein-protein interactions: application to study structure-function of plasminogen activation inhibitor 1 (PAI-I).
    Stoop AA; Jespers L; Lasters I; Eldering E; Pannekoek H
    J Mol Biol; 2000 Sep; 301(5):1135-47. PubMed ID: 10966811
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
    Clackson T; Ultsch MH; Wells JA; de Vos AM
    J Mol Biol; 1998 Apr; 277(5):1111-28. PubMed ID: 9571026
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High copy display of large proteins on phage for functional selections.
    Sidhu SS; Weiss GA; Wells JA
    J Mol Biol; 2000 Feb; 296(2):487-95. PubMed ID: 10669603
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
    Pál G; Ultsch MH; Clark KP; Currell B; Kossiakoff AA; Sidhu SS
    J Mol Biol; 2005 Apr; 347(3):489-94. PubMed ID: 15755445
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Computational detection of the binding-site hot spot at the remodeled human growth hormone-receptor interface.
    Verkhivker GM; Bouzida D; Gehlhaar DK; Rejto PA; Freer ST; Rose PW
    Proteins; 2003 Nov; 53(2):201-19. PubMed ID: 14517972
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling.
    O'Connor KH; Banga JP; Darmanin C; El-Kabbani O; Mackay IR; Rowley MJ
    J Autoimmun; 2006 May; 26(3):172-81. PubMed ID: 16564157
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure and site 1 binding energetics of human placental lactogen.
    Walsh ST; Kossiakoff AA
    J Mol Biol; 2006 May; 358(3):773-84. PubMed ID: 16546209
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
    Pal G; Kossiakoff AA; Sidhu SS
    J Mol Biol; 2003 Sep; 332(1):195-204. PubMed ID: 12946357
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dissecting the streptavidin-biotin interaction by phage-displayed shotgun scanning.
    Avrantinis SK; Stafford RL; Tian X; Weiss GA
    Chembiochem; 2002 Dec; 3(12):1229-34. PubMed ID: 12465031
    [TBL] [Abstract][Full Text] [Related]  

  • 16. High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.
    Fellouse FA; Esaki K; Birtalan S; Raptis D; Cancasci VJ; Koide A; Jhurani P; Vasser M; Wiesmann C; Kossiakoff AA; Koide S; Sidhu SS
    J Mol Biol; 2007 Nov; 373(4):924-40. PubMed ID: 17825836
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight.
    Covaceuszach S; Cattaneo A; Lamba D
    Proteins; 2005 Feb; 58(3):717-27. PubMed ID: 15625712
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Binding hot spots in the TEM1-BLIP interface in light of its modular architecture.
    Reichmann D; Cohen M; Abramovich R; Dym O; Lim D; Strynadka NC; Schreiber G
    J Mol Biol; 2007 Jan; 365(3):663-79. PubMed ID: 17070843
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The crystal structure of affinity-matured human growth hormone at 2 A resolution.
    Ultsch MH; Somers W; Kossiakoff AA; de Vos AM
    J Mol Biol; 1994 Feb; 236(1):286-99. PubMed ID: 8107110
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with single-domain camelid and shark antibodies.
    Lipovsek D; Lippow SM; Hackel BJ; Gregson MW; Cheng P; Kapila A; Wittrup KD
    J Mol Biol; 2007 May; 368(4):1024-41. PubMed ID: 17382960
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.