BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

271 related articles for article (PubMed ID: 15150082)

  • 1. Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment.
    Yuan J; Lovejoy DB; Richardson DR
    Blood; 2004 Sep; 104(5):1450-8. PubMed ID: 15150082
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells.
    Lovejoy DB; Richardson DR
    Blood; 2002 Jul; 100(2):666-76. PubMed ID: 12091363
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
    Richardson DR; Kalinowski DS; Richardson V; Sharpe PC; Lovejoy DB; Islam M; Bernhardt PV
    J Med Chem; 2009 Mar; 52(5):1459-70. PubMed ID: 19216562
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.
    Whitnall M; Howard J; Ponka P; Richardson DR
    Proc Natl Acad Sci U S A; 2006 Oct; 103(40):14901-6. PubMed ID: 17003122
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Kalinowski DS; Yu Y; Sharpe PC; Islam M; Liao YT; Lovejoy DB; Kumar N; Bernhardt PV; Richardson DR
    J Med Chem; 2007 Jul; 50(15):3716-29. PubMed ID: 17602603
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells.
    Noulsri E; Richardson DR; Lerdwana S; Fucharoen S; Yamagishi T; Kalinowski DS; Pattanapanyasat K
    Am J Hematol; 2009 Mar; 84(3):170-6. PubMed ID: 19140186
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.
    Yu Y; Suryo Rahmanto Y; Richardson DR
    Br J Pharmacol; 2012 Jan; 165(1):148-66. PubMed ID: 21658021
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells.
    Krishan S; Richardson DR; Sahni S
    Biochim Biophys Acta; 2016 Dec; 1863(12):2916-2933. PubMed ID: 27639899
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Examination of the antiproliferative activity of iron chelators: multiple cellular targets and the different mechanism of action of triapine compared with desferrioxamine and the potent pyridoxal isonicotinoyl hydrazone analogue 311.
    Chaston TB; Lovejoy DB; Watts RN; Richardson DR
    Clin Cancer Res; 2003 Jan; 9(1):402-14. PubMed ID: 12538494
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21
    Moussa RS; Kovacevic Z; Bae DH; Lane DJR; Richardson DR
    Biochim Biophys Acta Gen Subj; 2018 Mar; 1862(3):761-774. PubMed ID: 29032246
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
    Lovejoy DB; Sharp DM; Seebacher N; Obeidy P; Prichard T; Stefani C; Basha MT; Sharpe PC; Jansson PJ; Kalinowski DS; Bernhardt PV; Richardson DR
    J Med Chem; 2012 Aug; 55(16):7230-44. PubMed ID: 22861499
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.
    Stefani C; Jansson PJ; Gutierrez E; Bernhardt PV; Richardson DR; Kalinowski DS
    J Med Chem; 2013 Jan; 56(1):357-70. PubMed ID: 23276209
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
    Quach P; Gutierrez E; Basha MT; Kalinowski DS; Sharpe PC; Lovejoy DB; Bernhardt PV; Jansson PJ; Richardson DR
    Mol Pharmacol; 2012 Jul; 82(1):105-14. PubMed ID: 22508546
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.
    Opletalová V; Kalinowski DS; Vejsová M; Kunes J; Pour M; Jampílek J; Buchta V; Richardson DR
    Chem Res Toxicol; 2008 Sep; 21(9):1878-89. PubMed ID: 18698850
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action.
    Lui GY; Obeidy P; Ford SJ; Tselepis C; Sharp DM; Jansson PJ; Kalinowski DS; Kovacevic Z; Lovejoy DB; Richardson DR
    Mol Pharmacol; 2013 Jan; 83(1):179-90. PubMed ID: 23074173
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells.
    Park KC; Heo JH; Jeon JY; Choi HJ; Jo AR; Kim SW; Kwon HJ; Hong SJ; Han KS
    BMC Cancer; 2015 Jan; 15():19. PubMed ID: 25613585
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse.
    Huang SM; Hsu PC; Chen MY; Li WS; More SV; Lu KT; Wang YC
    Int J Cancer; 2012 Aug; 131(3):722-32. PubMed ID: 22015944
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.
    Huang Y; Hager ER; Phillips DL; Dunn VR; Hacker A; Frydman B; Kink JA; Valasinas AL; Reddy VK; Marton LJ; Casero RA; Davidson NE
    Clin Cancer Res; 2003 Jul; 9(7):2769-77. PubMed ID: 12855657
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.
    Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
    J Inorg Biochem; 2014 Dec; 141():43-54. PubMed ID: 25217717
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
    Stefani C; Punnia-Moorthy G; Lovejoy DB; Jansson PJ; Kalinowski DS; Sharpe PC; Bernhardt PV; Richardson DR
    J Med Chem; 2011 Oct; 54(19):6936-48. PubMed ID: 21846118
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.