142 related articles for article (PubMed ID: 15157876)
1. New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN.
Xu H; Heide L; Li SM
Chem Biol; 2004 May; 11(5):655-62. PubMed ID: 15157876
[TBL] [Abstract][Full Text] [Related]
2. In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach.
Galm U; Dessoy MA; Schmidt J; Wessjohann LA; Heide L
Chem Biol; 2004 Feb; 11(2):173-83. PubMed ID: 15123279
[TBL] [Abstract][Full Text] [Related]
3. Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host.
Freitag A; Rapp H; Heide L; Li SM
Chembiochem; 2005 Aug; 6(8):1411-8. PubMed ID: 15977275
[TBL] [Abstract][Full Text] [Related]
4. Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway.
Pacholec M; Freel Meyers CL; Oberthür M; Kahne D; Walsh CT
Biochemistry; 2005 Mar; 44(12):4949-56. PubMed ID: 15779922
[TBL] [Abstract][Full Text] [Related]
5. Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics.
Anderle C; Hennig S; Kammerer B; Li SM; Wessjohann L; Gust B; Heide L
Chem Biol; 2007 Aug; 14(8):955-67. PubMed ID: 17719494
[TBL] [Abstract][Full Text] [Related]
6. Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.
Freel Meyers CL; Oberthür M; Heide L; Kahne D; Walsh CT
Biochemistry; 2004 Nov; 43(47):15022-36. PubMed ID: 15554710
[TBL] [Abstract][Full Text] [Related]
7. Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties.
Heide L; Westrich L; Anderle C; Gust B; Kammerer B; Piel J
Chembiochem; 2008 Aug; 9(12):1992-9. PubMed ID: 18655076
[TBL] [Abstract][Full Text] [Related]
8. New aminocoumarin antibiotics from genetically engineered Streptomyces strains.
Li SM; Heide L
Curr Med Chem; 2005; 12(4):419-27. PubMed ID: 15720250
[TBL] [Abstract][Full Text] [Related]
9. The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin.
Tsai FT; Singh OM; Skarzynski T; Wonacott AJ; Weston S; Tucker A; Pauptit RA; Breeze AL; Poyser JP; O'Brien R; Ladbury JE; Wigley DB
Proteins; 1997 May; 28(1):41-52. PubMed ID: 9144789
[TBL] [Abstract][Full Text] [Related]
10. CloQ, a prenyltransferase involved in clorobiocin biosynthesis.
Pojer F; Wemakor E; Kammerer B; Chen H; Walsh CT; Li SM; Heide L
Proc Natl Acad Sci U S A; 2003 Mar; 100(5):2316-21. PubMed ID: 12618544
[TBL] [Abstract][Full Text] [Related]
11. Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides.
Gómez García I; Freel Meyers CL; Walsh CT; Lawson DM
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2008 Nov; 64(Pt 11):1000-2. PubMed ID: 18997325
[TBL] [Abstract][Full Text] [Related]
12. Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.
Freel Meyers CL; Oberthür M; Anderson JW; Kahne D; Walsh CT
Biochemistry; 2003 Apr; 42(14):4179-89. PubMed ID: 12680772
[TBL] [Abstract][Full Text] [Related]
13. CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin.
Westrich L; Heide L; Li SM
Chembiochem; 2003 Aug; 4(8):768-73. PubMed ID: 12898629
[TBL] [Abstract][Full Text] [Related]
14. Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7.
Fridman M; Balibar CJ; Lupoli T; Kahne D; Walsh CT; Garneau-Tsodikova S
Biochemistry; 2007 Jul; 46(28):8462-71. PubMed ID: 17580964
[TBL] [Abstract][Full Text] [Related]
15. Aminocoumarins mutasynthesis, chemoenzymatic synthesis, and metabolic engineering.
Heide L
Methods Enzymol; 2009; 459():437-55. PubMed ID: 19362650
[TBL] [Abstract][Full Text] [Related]
16. Streptococcus pneumononiae gyrase ATPase: development and validation of an assay for inhibitor discovery and characterization.
Miller JR; Herberg JT; Tomilo M; McCroskey MC; Feilmeier BJ
Anal Biochem; 2007 Jun; 365(1):132-43. PubMed ID: 17395144
[TBL] [Abstract][Full Text] [Related]
17. NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis.
Pacholec M; Hillson NJ; Walsh CT
Biochemistry; 2005 Sep; 44(38):12819-26. PubMed ID: 16171397
[TBL] [Abstract][Full Text] [Related]
18. Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins.
Heide L
Biotechnol Adv; 2009; 27(6):1006-1014. PubMed ID: 19463934
[TBL] [Abstract][Full Text] [Related]
19. A 4.2 kDa synthetic peptide as a potential probe to evaluate the antibacterial activity of coumarin drugs.
Scatigno AC; Garrido SS; Marchetto R
J Pept Sci; 2004 Sep; 10(9):566-77. PubMed ID: 15473264
[TBL] [Abstract][Full Text] [Related]
20. Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin.
Xu H; Wang ZX; Schmidt J; Heide L; Li SM
Mol Genet Genomics; 2002 Nov; 268(3):387-96. PubMed ID: 12436260
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]