BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

348 related articles for article (PubMed ID: 15163210)

  • 1. Mitomycin dimers: polyfunctional cross-linkers of DNA.
    Paz MM; Kumar GS; Glover M; Waring MJ; Tomasz M
    J Med Chem; 2004 Jun; 47(12):3308-19. PubMed ID: 15163210
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 7-N,7'-N'-(1",2"-Dithianyl-3",6"-dimethylenyl)bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin.
    Lee SH; Kohn H
    Org Biomol Chem; 2005 Feb; 3(3):471-82. PubMed ID: 15678185
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and function modification of DNA by mitomycin C. Mechanism of the DNA sequence specificity of mitomycins.
    Gargiulo D; Kumar GS; Musser SS; Tomasz M
    Nucleic Acids Symp Ser; 1995; (34):169-70. PubMed ID: 8841606
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.
    Palom Y; Belcourt MF; Kumar GS; Arai H; Kasai M; Sartorelli AC; Rockwell S; Tomasz M
    Oncol Res; 1998; 10(10):509-21. PubMed ID: 10338154
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines.
    Kim SY; Rockwell S
    Oncol Res; 1995; 7(5):39-47. PubMed ID: 8534933
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential.
    Paz MM; Das A; Palom Y; He QY; Tomasz M
    J Med Chem; 2001 Aug; 44(17):2834-42. PubMed ID: 11495594
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines.
    Rockwell S; Kim SY
    Oncol Res; 1995; 7(1):39-47. PubMed ID: 7549043
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.
    Fracasso PM; Sartorelli AC
    Cancer Res; 1986 Aug; 46(8):3939-44. PubMed ID: 3089583
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns.
    Bizanek R; Chowdary D; Arai H; Kasai M; Hughes CS; Sartorelli AC; Rockwell S; Tomasz M
    Cancer Res; 1993 Nov; 53(21):5127-34. PubMed ID: 7693331
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity.
    Paz MM; Das TA; Tomasz M
    Bioorg Med Chem; 1999 Dec; 7(12):2713-26. PubMed ID: 10658576
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sequence-specific DNA interstrand cross-linking by an aziridinomitosene in the absence of exogenous reductant.
    Rink SM; Warner DL; Klapars A; Vedejs E
    Biochemistry; 2005 Oct; 44(42):13981-6. PubMed ID: 16229487
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Studies on synthesis and activation mechanism of mitomycin dimers connected by 1,2-dithiolane and diol linkers.
    Kim HR; Kim JJ; Park JJ; Lee SH
    Bioorg Med Chem; 2012 Oct; 20(19):5720-9. PubMed ID: 22959767
    [TBL] [Abstract][Full Text] [Related]  

  • 13. pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells.
    Kennedy KA; McGurl JD; Leondaridis L; Alabaster O
    Cancer Res; 1985 Aug; 45(8):3541-7. PubMed ID: 3926302
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
    Keyes SR; Rockwell S; Sartorelli AC
    Cancer Res; 1989 Jun; 49(12):3310-3. PubMed ID: 2470504
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
    Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
    J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, DNA cross-linking activity, and cytotoxicity of dimeric mitomycins.
    Na Y; Li VS; Nakanishi Y; Bastow KF; Kohn H
    J Med Chem; 2001 Oct; 44(21):3453-62. PubMed ID: 11585450
    [TBL] [Abstract][Full Text] [Related]  

  • 17. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
    Hartley JA; Spanswick VJ; Brooks N; Clingen PH; McHugh PJ; Hochhauser D; Pedley RB; Kelland LR; Alley MC; Schultz R; Hollingshead MG; Schweikart KM; Tomaszewski JE; Sausville EA; Gregson SJ; Howard PW; Thurston DE
    Cancer Res; 2004 Sep; 64(18):6693-9. PubMed ID: 15374986
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Antisense sequence-directed cross-linking of RNA oligonucleotides by mitomycin.
    Maruenda H; Tomasz M
    Anticancer Drug Des; 1997 Sep; 12(6):473-9. PubMed ID: 9311556
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles.
    Atwell GJ; Fan JY; Tan K; Denny WA
    J Med Chem; 1998 Nov; 41(24):4744-54. PubMed ID: 9822545
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of the superoxide dismutase inhibitor, diethyldithiocarbamate, on the cytotoxicity of mitomycin antibiotics.
    Pritsos CA; Keyes SR; Sartorelli AC
    Cancer Biochem Biophys; 1989 Oct; 10(4):289-98. PubMed ID: 2559790
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.