BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 15166315)

  • 1. Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase.
    Kursula I; Salin M; Sun J; Norledge BV; Haapalainen AM; Sampson NS; Wierenga RK
    Protein Eng Des Sel; 2004 Apr; 17(4):375-82. PubMed ID: 15166315
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.
    Alahuhta M; Casteleijn MG; Neubauer P; Wierenga RK
    Acta Crystallogr D Biol Crystallogr; 2008 Feb; 64(Pt 2):178-88. PubMed ID: 18219118
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The importance of hinge sequence for loop function and catalytic activity in the reaction catalyzed by triosephosphate isomerase.
    Xiang J; Sun J; Sampson NS
    J Mol Biol; 2001 Apr; 307(4):1103-12. PubMed ID: 11286559
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Understanding protein lids: kinetic analysis of active hinge mutants in triosephosphate isomerase.
    Sun J; Sampson NS
    Biochemistry; 1999 Aug; 38(35):11474-81. PubMed ID: 10471299
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Active site properties of monomeric triosephosphate isomerase (monoTIM) as deduced from mutational and structural studies.
    Schliebs W; Thanki N; Eritja R; Wierenga R
    Protein Sci; 1996 Feb; 5(2):229-39. PubMed ID: 8745400
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Entropy effects on protein hinges: the reaction catalyzed by triosephosphate isomerase.
    Xiang J; Jung JY; Sampson NS
    Biochemistry; 2004 Sep; 43(36):11436-45. PubMed ID: 15350130
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Functional role of the conserved active site proline of triosephosphate isomerase.
    Casteleijn MG; Alahuhta M; Groebel K; El-Sayed I; Augustyns K; Lambeir AM; Neubauer P; Wierenga RK
    Biochemistry; 2006 Dec; 45(51):15483-94. PubMed ID: 17176070
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structures of unliganded and inhibitor complexes of W168F, a Loop6 hinge mutant of Plasmodium falciparum triosephosphate isomerase: observation of an intermediate position of loop6.
    Eaazhisai K; Balaram H; Balaram P; Murthy MR
    J Mol Biol; 2004 Oct; 343(3):671-84. PubMed ID: 15465054
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based protein engineering efforts with a monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties.
    Alahuhta M; Salin M; Casteleijn MG; Kemmer C; El-Sayed I; Augustyns K; Neubauer P; Wierenga RK
    Protein Eng Des Sel; 2008 Apr; 21(4):257-66. PubMed ID: 18239072
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase.
    Wierenga RK; Noble ME; Postma JP; Groendijk H; Kalk KH; Hol WG; Opperdoes FR
    Proteins; 1991; 10(1):33-49. PubMed ID: 2062827
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase.
    Salin M; Kapetaniou EG; Vaismaa M; Lajunen M; Casteleijn MG; Neubauer P; Salmon L; Wierenga RK
    Acta Crystallogr D Biol Crystallogr; 2010 Aug; 66(Pt 8):934-44. PubMed ID: 20693693
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structures of the "open" and "closed" state of trypanosomal triosephosphate isomerase, as observed in a new crystal form: implications for the reaction mechanism.
    Noble ME; Zeelen JP; Wierenga RK
    Proteins; 1993 Aug; 16(4):311-26. PubMed ID: 8356028
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site.
    Gayathri P; Banerjee M; Vijayalakshmi A; Balaram H; Balaram P; Murthy MR
    Acta Crystallogr D Biol Crystallogr; 2009 Aug; 65(Pt 8):847-57. PubMed ID: 19622869
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A double mutation at the tip of the dimer interface loop of triosephosphate isomerase generates active monomers with reduced stability.
    Schliebs W; Thanki N; Jaenicke R; Wierenga RK
    Biochemistry; 1997 Aug; 36(32):9655-62. PubMed ID: 9245397
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Active site loop motion in triosephosphate isomerase: T-jump relaxation spectroscopy of thermal activation.
    Desamero R; Rozovsky S; Zhadin N; McDermott A; Callender R
    Biochemistry; 2003 Mar; 42(10):2941-51. PubMed ID: 12627960
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Solution-state NMR investigations of triosephosphate isomerase active site loop motion: ligand release in relation to active site loop dynamics.
    Rozovsky S; Jogl G; Tong L; McDermott AE
    J Mol Biol; 2001 Jun; 310(1):271-80. PubMed ID: 11419952
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hydrophobic repacking of the dimer interface of triosephosphate isomerase by in silico design and directed evolution.
    Peimbert M; Domínguez-Ramírez L; Fernández-Velasco DA
    Biochemistry; 2008 May; 47(20):5556-64. PubMed ID: 18439027
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dynamic requirements for a functional protein hinge.
    Kempf JG; Jung JY; Ragain C; Sampson NS; Loria JP
    J Mol Biol; 2007 Apr; 368(1):131-49. PubMed ID: 17336327
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The time scale of the catalytic loop motion in triosephosphate isomerase.
    Rozovsky S; McDermott AE
    J Mol Biol; 2001 Jun; 310(1):259-70. PubMed ID: 11419951
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The role of water in the catalytic efficiency of triosephosphate isomerase.
    Zhang Z; Komives EA; Sugio S; Blacklow SC; Narayana N; Xuong NH; Stock AM; Petsko GA; Ringe D
    Biochemistry; 1999 Apr; 38(14):4389-97. PubMed ID: 10194358
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.