BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 15169628)

  • 1. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG; Cao CX; Pommier Y
    Acta Pharmacol Sin; 2004 Jun; 25(6):756-62. PubMed ID: 15169628
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine.
    Sampath D; Shi Z; Plunkett W
    Mol Pharmacol; 2002 Sep; 62(3):680-8. PubMed ID: 12181445
    [TBL] [Abstract][Full Text] [Related]  

  • 3. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
    Wang Q; Fan S; Eastman A; Worland PJ; Sausville EA; O'Connor PM
    J Natl Cancer Inst; 1996 Jul; 88(14):956-65. PubMed ID: 8667426
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
    Shao RG; Cao CX; Shimizu T; O'Connor PM; Kohn KW; Pommier Y
    Cancer Res; 1997 Sep; 57(18):4029-35. PubMed ID: 9307289
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
    Hutchins JR; Dikovskaya D; Clarke PR
    Mol Biol Cell; 2003 Oct; 14(10):4003-14. PubMed ID: 14517314
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.
    Busby EC; Leistritz DF; Abraham RT; Karnitz LM; Sarkaria JN
    Cancer Res; 2000 Apr; 60(8):2108-12. PubMed ID: 10786669
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation.
    Liu X; Guo Y; Li Y; Jiang Y; Chubb S; Azuma A; Huang P; Matsuda A; Hittelman W; Plunkett W
    Cancer Res; 2005 Aug; 65(15):6874-81. PubMed ID: 16061671
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
    Eastman A; Kohn EA; Brown MK; Rathman J; Livingstone M; Blank DH; Gribble GW
    Mol Cancer Ther; 2002 Oct; 1(12):1067-78. PubMed ID: 12481430
    [TBL] [Abstract][Full Text] [Related]  

  • 9. p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Wang XQ; Stanbridge EJ; Lao X; Cai Q; Fan ST; Redpath JL
    Radiat Res; 2007 Dec; 168(6):706-15. PubMed ID: 18088187
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
    Guo N; Faller DV; Vaziri C
    Cell Growth Differ; 2002 Feb; 13(2):77-86. PubMed ID: 11864911
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe.
    Tse AN; Schwartz GK
    Cancer Res; 2004 Sep; 64(18):6635-44. PubMed ID: 15374978
    [TBL] [Abstract][Full Text] [Related]  

  • 12. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q; La Rose J; Zhang H; Takemura H; Kohn KW; Pommier Y
    Cancer Res; 2002 Oct; 62(20):5743-8. PubMed ID: 12384533
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
    Hirose Y; Berger MS; Pieper RO
    Cancer Res; 2001 Aug; 61(15):5843-9. PubMed ID: 11479224
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
    Kohn EA; Ruth ND; Brown MK; Livingstone M; Eastman A
    J Biol Chem; 2002 Jul; 277(29):26553-64. PubMed ID: 11953432
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
    Graves PR; Yu L; Schwarz JK; Gales J; Sausville EA; O'Connor PM; Piwnica-Worms H
    J Biol Chem; 2000 Feb; 275(8):5600-5. PubMed ID: 10681541
    [TBL] [Abstract][Full Text] [Related]  

  • 16. UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
    Sugiyama K; Shimizu M; Akiyama T; Tamaoki T; Yamaguchi K; Takahashi R; Eastman A; Akinaga S
    Int J Cancer; 2000 Mar; 85(5):703-9. PubMed ID: 10699952
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.
    Bunch RT; Eastman A
    Clin Cancer Res; 1996 May; 2(5):791-7. PubMed ID: 9816232
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial.
    Lara PN; Mack PC; Synold T; Frankel P; Longmate J; Gumerlock PH; Doroshow JH; Gandara DR
    Clin Cancer Res; 2005 Jun; 11(12):4444-50. PubMed ID: 15958629
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
    Levesque AA; Fanous AA; Poh A; Eastman A
    Mol Cancer Ther; 2008 Feb; 7(2):252-62. PubMed ID: 18281511
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer.
    Yin M; Hapke G; Guo B; Azrak RG; Frank C; Rustum YM
    Oncogene; 2001 Aug; 20(38):5249-57. PubMed ID: 11536038
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.