BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

388 related articles for article (PubMed ID: 15170323)

  • 1. Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism.
    Szebenyi DM; Musayev FN; di Salvo ML; Safo MK; Schirch V
    Biochemistry; 2004 Jun; 43(22):6865-76. PubMed ID: 15170323
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Serine hydroxymethyltransferase revisited.
    Schirch V; Szebenyi DM
    Curr Opin Chem Biol; 2005 Oct; 9(5):482-7. PubMed ID: 16125438
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory.
    Rajaram V; Bhavani BS; Kaul P; Prakash V; Appaji Rao N; Savithri HS; Murthy MR
    FEBS J; 2007 Aug; 274(16):4148-60. PubMed ID: 17651438
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of rabbit cytosolic serine hydroxymethyltransferase at 2.8 A resolution: mechanistic implications.
    Scarsdale JN; Kazanina G; Radaev S; Schirch V; Wright HT
    Biochemistry; 1999 Jun; 38(26):8347-58. PubMed ID: 10387080
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate.
    Scarsdale JN; Radaev S; Kazanina G; Schirch V; Wright HT
    J Mol Biol; 2000 Feb; 296(1):155-68. PubMed ID: 10656824
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases.
    Chang WN; Tsai JN; Chen BH; Huang HS; Fu TF
    Drug Metab Dispos; 2007 Nov; 35(11):2127-37. PubMed ID: 17664250
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers.
    Szebenyi DM; Liu X; Kriksunov IA; Stover PJ; Thiel DJ
    Biochemistry; 2000 Nov; 39(44):13313-23. PubMed ID: 11063567
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Properties of human and rabbit cytosolic serine hydroxymethyltransferase are changed by single nucleotide polymorphic mutations.
    Fu TF; Hunt S; Schirch V; Safo MK; Chen BH
    Arch Biochem Biophys; 2005 Oct; 442(1):92-101. PubMed ID: 16137637
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of tyrosine 65 in the mechanism of serine hydroxymethyltransferase.
    Contestabile R; Angelaccio S; Bossa F; Wright HT; Scarsdale N; Kazanina G; Schirch V
    Biochemistry; 2000 Jun; 39(25):7492-500. PubMed ID: 10858298
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
    Trivedi V; Gupta A; Jala VR; Saravanan P; Rao GS; Rao NA; Savithri HS; Subramanya HS
    J Biol Chem; 2002 May; 277(19):17161-9. PubMed ID: 11877399
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase.
    Rao JV; Prakash V; Rao NA; Savithri HS
    Eur J Biochem; 2000 Oct; 267(19):5967-76. PubMed ID: 10998057
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed.
    Daidone F; Florio R; Rinaldo S; Contestabile R; di Salvo ML; CutruzzolĂ  F; Bossa F; Paiardini A
    Eur J Med Chem; 2011 May; 46(5):1616-21. PubMed ID: 21371789
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.
    Bhavani BS; Rajaram V; Bisht S; Kaul P; Prakash V; Murthy MR; Appaji Rao N; Savithri HS
    FEBS J; 2008 Sep; 275(18):4606-19. PubMed ID: 18699779
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy.
    Renwick SB; Snell K; Baumann U
    Structure; 1998 Sep; 6(9):1105-16. PubMed ID: 9753690
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?
    Heil SG; Van der Put NM; Waas ET; den Heijer M; Trijbels FJ; Blom HJ
    Mol Genet Metab; 2001 Jun; 73(2):164-72. PubMed ID: 11386852
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-function relationship in serine hydroxymethyltransferase.
    Appaji Rao N; Ambili M; Jala VR; Subramanya HS; Savithri HS
    Biochim Biophys Acta; 2003 Apr; 1647(1-2):24-9. PubMed ID: 12686103
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Serine hydroxymethyltransferase catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 5-formyltetrahydrofolate.
    Stover P; Schirch V
    J Biol Chem; 1990 Aug; 265(24):14227-33. PubMed ID: 2201683
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves.
    Goyer A; Collakova E; DĂ­az de la Garza R; Quinlivan EP; Williamson J; Gregory JF; Shachar-Hill Y; Hanson AD
    J Biol Chem; 2005 Jul; 280(28):26137-42. PubMed ID: 15888445
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia.
    Okamura-Ikeda K; Hosaka H; Yoshimura M; Yamashita E; Toma S; Nakagawa A; Fujiwara K; Motokawa Y; Taniguchi H
    J Mol Biol; 2005 Sep; 351(5):1146-59. PubMed ID: 16051266
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues.
    Sopitthummakhun K; Maenpuen S; Yuthavong Y; Leartsakulpanich U; Chaiyen P
    FEBS J; 2009 Aug; 276(15):4023-36. PubMed ID: 19549189
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.