These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

207 related articles for article (PubMed ID: 15177452)

  • 1. Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.
    Hu B; Fan KY; Bridges K; Chopra R; Lovering F; Cole D; Zhou P; Ellingboe J; Jin G; Cowling R; Bard J
    Bioorg Med Chem Lett; 2004 Jul; 14(13):3457-60. PubMed ID: 15177452
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase.
    Hom RK; Fang LY; Mamo S; Tung JS; Guinn AC; Walker DE; Davis DL; Gailunas AF; Thorsett ED; Sinha S; Knops JE; Jewett NE; Anderson JP; John V
    J Med Chem; 2003 May; 46(10):1799-802. PubMed ID: 12723942
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.
    Hom RK; Gailunas AF; Mamo S; Fang LY; Tung JS; Walker DE; Davis D; Thorsett ED; Jewett NE; Moon JB; John V
    J Med Chem; 2004 Jan; 47(1):158-64. PubMed ID: 14695829
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
    Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
    Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core.
    Wångsell F; Gustafsson K; Kvarnström I; Borkakoti N; Edlund M; Jansson K; Lindberg J; Hallberg A; Rosenquist A; Samuelsson B
    Eur J Med Chem; 2010 Mar; 45(3):870-82. PubMed ID: 20036448
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Macrocyclic statine-based inhibitors of BACE-1.
    Barazza A; Götz M; Cadamuro SA; Goettig P; Willem M; Steuber H; Kohler T; Jestel A; Reinemer P; Renner C; Bode W; Moroder L
    Chembiochem; 2007 Nov; 8(17):2078-91. PubMed ID: 17963207
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A novel approach to identifying beta-secretase inhibitors: bis-statine peptide mimetics discovered using structure and spot synthesis.
    Bridges KG; Chopra R; Lin L; Svenson K; Tam A; Jin G; Cowling R; Lovering F; Akopian TN; DiBlasio-Smith E; Annis-Freeman B; Marvell TH; LaVallie ER; Zollner RS; Bard J; Somers WS; Stahl ML; Kriz RW
    Peptides; 2006 Jul; 27(7):1877-85. PubMed ID: 16574278
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.
    Stauffer SR; Stanton MG; Gregro AR; Steinbeiser MA; Shaffer JR; Nantermet PG; Barrow JC; Rittle KE; Collusi D; Espeseth AS; Lai MT; Pietrak BL; Holloway MK; McGaughey GB; Munshi SK; Hochman JH; Simon AJ; Selnick HG; Graham SL; Vacca JP
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1788-92. PubMed ID: 17257835
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design and synthesis of statine-containing BACE inhibitors.
    Hu J; Cwi CL; Smiley DL; Timm D; Erickson JA; McGee JE; Yang HC; Mendel D; May PC; Shapiro M; McCarthy JR
    Bioorg Med Chem Lett; 2003 Dec; 13(24):4335-9. PubMed ID: 14643321
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.
    Maillard MC; Hom RK; Benson TE; Moon JB; Mamo S; Bienkowski M; Tomasselli AG; Woods DD; Prince DB; Paddock DJ; Emmons TL; Tucker JA; Dappen MS; Brogley L; Thorsett ED; Jewett N; Sinha S; John V
    J Med Chem; 2007 Feb; 50(4):776-81. PubMed ID: 17300163
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evaluating scoring functions for docking and designing beta-secretase inhibitors.
    Katharine Holloway M; McGaughey GB; Coburn CA; Stachel SJ; Jones KG; Stanton EL; Gregro AR; Lai MT; Crouthamel MC; Pietrak BL; Munshi SK
    Bioorg Med Chem Lett; 2007 Feb; 17(3):823-7. PubMed ID: 17107793
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
    Wang YS; Strickland C; Voigt JH; Kennedy ME; Beyer BM; Senior MM; Smith EM; Nechuta TL; Madison VS; Czarniecki M; McKittrick BA; Stamford AW; Parker EM; Hunter JC; Greenlee WJ; Wyss DF
    J Med Chem; 2010 Feb; 53(3):942-50. PubMed ID: 20043700
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).
    Stachel SJ; Coburn CA; Steele TG; Jones KG; Loutzenhiser EF; Gregro AR; Rajapakse HA; Lai MT; Crouthamel MC; Xu M; Tugusheva K; Lineberger JE; Pietrak BL; Espeseth AS; Shi XP; Chen-Dodson E; Holloway MK; Munshi S; Simon AJ; Kuo L; Vacca JP
    J Med Chem; 2004 Dec; 47(26):6447-50. PubMed ID: 15588077
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular docking and structure-activity relationship studies on benzothiazole based non-peptidic BACE-1 inhibitors.
    Xu W; Chen G; Zhu W; Zuo Z
    Bioorg Med Chem Lett; 2010 Nov; 20(21):6203-7. PubMed ID: 20850315
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
    Hanessian S; Shao Z; Betschart C; Rondeau JM; Neumann U; Tintelnot-Blomley M
    Bioorg Med Chem Lett; 2010 Mar; 20(6):1924-7. PubMed ID: 20172717
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.
    Bakshi P; Wolfe MS
    J Med Chem; 2004 Dec; 47(26):6485-9. PubMed ID: 15588083
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
    Edwards PD; Albert JS; Sylvester M; Aharony D; Andisik D; Callaghan O; Campbell JB; Carr RA; Chessari G; Congreve M; Frederickson M; Folmer RH; Geschwindner S; Koether G; Kolmodin K; Krumrine J; Mauger RC; Murray CW; Olsson LL; Patel S; Spear N; Tian G
    J Med Chem; 2007 Nov; 50(24):5912-25. PubMed ID: 17985862
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.
    Abbenante G; Kovacs DM; Leung DL; Craik DJ; Tanzi RE; Fairlie DP
    Biochem Biophys Res Commun; 2000 Feb; 268(1):133-5. PubMed ID: 10652226
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core.
    Björklund C; Adolfsson H; Jansson K; Lindberg J; Vrang L; Hallberg A; Rosenquist S; Samuelsson B
    Bioorg Med Chem; 2010 Feb; 18(4):1711-23. PubMed ID: 20122837
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.
    Garino C; Tomita T; Pietrancosta N; Laras Y; Rosas R; Herbette G; Maigret B; Quéléver G; Iwatsubo T; Kraus JL
    J Med Chem; 2006 Jul; 49(14):4275-85. PubMed ID: 16821787
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.