BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

321 related articles for article (PubMed ID: 15180983)

  • 1. The FAD-shielding residue Phe1395 regulates neuronal nitric-oxide synthase catalysis by controlling NADP+ affinity and a conformational equilibrium within the flavoprotein domain.
    Konas DW; Zhu K; Sharma M; Aulak KS; Brudvig GW; Stuehr DJ
    J Biol Chem; 2004 Aug; 279(34):35412-25. PubMed ID: 15180983
    [TBL] [Abstract][Full Text] [Related]  

  • 2. C-terminal tail residue Arg1400 enables NADPH to regulate electron transfer in neuronal nitric-oxide synthase.
    Tiso M; Konas DW; Panda K; Garcin ED; Sharma M; Getzoff ED; Stuehr DJ
    J Biol Chem; 2005 Nov; 280(47):39208-19. PubMed ID: 16150731
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein.
    Konas DW; Takaya N; Sharma M; Stuehr DJ
    Biochemistry; 2006 Oct; 45(41):12596-609. PubMed ID: 17029414
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Differences in a conformational equilibrium distinguish catalysis by the endothelial and neuronal nitric-oxide synthase flavoproteins.
    Ilagan RP; Tiso M; Konas DW; Hemann C; Durra D; Hille R; Stuehr DJ
    J Biol Chem; 2008 Jul; 283(28):19603-15. PubMed ID: 18487202
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Redox properties of the isolated flavin mononucleotide- and flavin adenine dinucleotide-binding domains of neuronal nitric oxide synthase.
    Garnaud PE; Koetsier M; Ost TW; Daff S
    Biochemistry; 2004 Aug; 43(34):11035-44. PubMed ID: 15323562
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Tryptophan 697 modulates hydride and interflavin electron transfer in human methionine synthase reductase.
    Meints CE; Gustafsson FS; Scrutton NS; Wolthers KR
    Biochemistry; 2011 Dec; 50(51):11131-42. PubMed ID: 22097960
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395.
    Dunford AJ; Marshall KR; Munro AW; Scrutton NS
    Eur J Biochem; 2004 Jun; 271(12):2548-60. PubMed ID: 15182370
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail.
    Tiso M; Tejero J; Panda K; Aulak KS; Stuehr DJ
    Biochemistry; 2007 Dec; 46(50):14418-28. PubMed ID: 18020458
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.
    Haque MM; Fadlalla MA; Aulak KS; Ghosh A; Durra D; Stuehr DJ
    J Biol Chem; 2012 Aug; 287(36):30105-16. PubMed ID: 22722929
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme.
    Adak S; Ghosh S; Abu-Soud HM; Stuehr DJ
    J Biol Chem; 1999 Aug; 274(32):22313-20. PubMed ID: 10428800
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of a conserved serine residue within hydrogen bonding distance of FAD in redox properties and the modulation of catalysis by Ca2+/calmodulin of constitutive nitric-oxide synthases.
    Panda SP; Gao YT; Roman LJ; Martásek P; Salerno JC; Masters BS
    J Biol Chem; 2006 Nov; 281(45):34246-57. PubMed ID: 16966328
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains.
    Guan ZW; Kamatani D; Kimura S; Iyanagi T
    J Biol Chem; 2003 Aug; 278(33):30859-68. PubMed ID: 12777376
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis.
    Panda K; Adak S; Konas D; Sharma M; Stuehr DJ
    J Biol Chem; 2004 Apr; 279(18):18323-33. PubMed ID: 14966111
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity.
    Adak S; Sharma M; Meade AL; Stuehr DJ
    Proc Natl Acad Sci U S A; 2002 Oct; 99(21):13516-21. PubMed ID: 12359874
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase.
    Zhang J; Martàsek P; Paschke R; Shea T; Siler Masters BS; Kim JJ
    J Biol Chem; 2001 Oct; 276(40):37506-13. PubMed ID: 11473123
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Stopped-flow kinetic studies of electron transfer in the reductase domain of neuronal nitric oxide synthase: re-evaluation of the kinetic mechanism reveals new enzyme intermediates and variation with cytochrome P450 reductase.
    Knight K; Scrutton NS
    Biochem J; 2002 Oct; 367(Pt 1):19-30. PubMed ID: 12079493
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Electron transfer is activated by calmodulin in the flavin domain of human neuronal nitric oxide synthase.
    Guan ZW; Iyanagi T
    Arch Biochem Biophys; 2003 Apr; 412(1):65-76. PubMed ID: 12646269
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interflavin one-electron transfer in the inducible nitric oxide synthase reductase domain and NADPH-cytochrome P450 reductase.
    Yamamoto K; Kimura S; Shiro Y; Iyanagi T
    Arch Biochem Biophys; 2005 Aug; 440(1):65-78. PubMed ID: 16009330
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism.
    Tejero J; Haque MM; Durra D; Stuehr DJ
    J Biol Chem; 2010 Aug; 285(34):25941-9. PubMed ID: 20529840
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis.
    Dai Y; Haque MM; Stuehr DJ
    J Biol Chem; 2017 Apr; 292(16):6753-6764. PubMed ID: 28232486
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.